Isoprene Exposure in the United States based on Urinary IPM3: NHANES 2015-2016

Details

• Alternative Title:
  Environ Sci Technol
• Personal Author:
  Biren, Chloe ; Zhang, Luyu ; Bhandari, Deepak ; Blount, Benjamin C. ; De Jesús, Víctor R.
• Description:
  Isoprene is the 2-methyl analog of 1,3-butadiene and is a possible human carcinogen (IARC Group 2B). We assessed isoprene exposure in the general US population by measuring its urinary metabolite, |-acetyl-|-(4-hydroxy-2-methyl-2-buten-1-yl)-l-cysteine (IPM3) in participants (≥3 year old) from the 2015-2016 National Health and Nutrition Examination Survey. Spot urine samples were analyzed for IPM3 using ultrahigh-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Exclusive tobacco smokers were distinguished from non-users using a combination of self-reporting and serum cotinine data. IPM3 was detected in 80.2% of samples. The median IPM3 level was higher for exclusive cigarette smokers (39.8 μg/g creatinine) than for non-users (3.05 μg/g creatinine). Sample weighted regression analysis, controlling for creatinine, sex, age, race, body mass index, and diet, showed that IPM3 was positively and significantly associated with serum cotinine. Smoking 1-10 cigarettes per day (CPD, 0.5 pack) was significantly associated with an IPM3 increase of 596% (| < .0001), and smoking >20 CPD (>1 pack) was significantly associated with an IPM3 increase of 1640% (| < .0001), controlling for confounding variables. Drinking beer/ale at median and 90th percentile levels (compared to zero consumption) was associated (| < 0.05) with 0 and 2.9% increase in IPM3 in non-users, respectively. We conclude that tobacco smoke is a major source of isoprene exposure in the US population. This study provides important public health biomonitoring data on isoprene exposure in the general US population.
• Subjects:
  Biomarkers Butadienes Child, Preschool Cotinine Hemiterpenes Humans Nutrition Surveys Tobacco Smoke Pollution
• Source:
  Environ Sci Technol. 54(4):2370-2378
• Pubmed ID:
  31961658
• Pubmed Central ID:
  PMC7931248
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHS/United States
• Name as Subject:
  National Health and Nutrition Examination Survey (U.S.)
• Place as Subject:
  United States
• Volume:
  54
• Issue:
  4
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7472b89e2ac67203b952c88a4d233c3696754bc87ef1d0ab4c8b372ceed313f4
• Download URL:
  https://stacks.cdc.gov/view/cdc/103814/cdc_103814_DS1.pdf
• File Type:
  [PDF - 538.95 KB ]