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First identified cases of SARS-CoV-2 Variants P.1 in the United States — Minnesota, January 2021
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March 3, 2021
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Description:Since December 2020, the Minnesota Department of Health (MDH) Public Health Laboratory has been receiving 100 specimens per week (50 from each of two clinical partners) with low cycle threshold (Ct) values for routine Surveillance for SARS-CoV-2, the Virus that causes COVID-19. On January 25, 2021, MDH identified the SARS-CoV-2 Variants P.1 in one specimen through this Surveillance system using whole genome sequencing, representing the first identified case of this Variants in the United States The P.1 Variants was first identified in travelers from Brazil during routine airport screening in Tokyo, Japan, in early January 2021 (1). This Variants has been associated with increased transmissibility (2), and there are concerns that mutations in the spike protein receptor-binding domain might disrupt both vaccine-induced and natural immunity (3,4). As of February 28, 2021, a total of 10 P.1 cases had been identified in the United States, including the two cases described in this report, followed by one case each in Alaska, Florida, Maryland, and Oklahoma (5).
The first Minnesota P.1 Variants case was identified in a person who became symptomatic in early January and was hospitalized for 9 days. During the case investigation, the person reported having traveled to southeastern Brazil within the 14 days before symptom onset. The patient’s travel partner, who lived in the same household, also had symptoms of COVID-19 and received a positive SARS-CoV-2 test result after returning. The diagnostic specimen from this household contact was obtained for whole genome sequencing and confirmed to be the P.1 Variants. The sequences from both patients were identical and had 15 of the 17 mutations associated with the P.1 Variants, including the 10 S-gene mutations (2). The Minnesota patients were reinterviewed to obtain information on exposures and close contacts.† This activity was reviewed by CDC and conducted consistent with applicable federal law and policy.§
Suggested citation for this article: Firestone MJ, Lorentz AJ, Meyer S, et al. First Identified Cases of SARS-CoV-2 Variant P.1 in the United States — Minnesota, January 2021. MMWR Morb Mortal Wkly Rep. ePub: 3 March 2021.
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