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Vaccine-Derived Polioviruses, Central African Republic, 2019
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Feb 2021
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Source: Emerg Infect Dis. 27(2):620-623
[PDF-1.70 MB]
Details:
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Alternative Title:Emerg Infect Dis
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Personal Author:
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Description:Since May 2019, the Central African Republic has experienced a poliomyelitis outbreak caused by type 2 vaccine-derived polioviruses (VDPV-2s). The outbreak affected Bangui, the capital city, and 10 districts across the country. The outbreak resulted from several independent emergence events of VDPV-2s featuring recombinant genomes with complex mosaic genomes. The low number of mutations (<20) in the viral capsid protein 1-encoding region compared with the vaccine strain suggests that VDPV-2 had been circulating for a relatively short time (probably <3 years) before being isolated. Environmental surveillance, which relies on a limited number of sampling sites in the Central African Republic and does not cover the whole country, failed to detect the circulation of VDPV-2s before some had induced poliomyelitis in children.
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Pubmed ID:33496226
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Pubmed Central ID:PMC7853572
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Volume:27
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Issue:2
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