Vaccine-Derived Polioviruses, Central African Republic, 2019

Joffret, Marie-Line; Doté, Joël Wilfried; Gumede, Nicksy; Vignuzzi, Marco; Bessaud, Maël; Gouandjika-Vasilache, Ionela

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Vaccine-Derived Polioviruses, Central African Republic, 2019

Feb 2021
By Joffret, Marie-Line ; Doté, Joël Wilfried ; Gumede, Nicksy ; ...
Source: Emerg Infect Dis. 27(2):620-623

[PDF-1.70 MB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Joffret, Marie-Line ; Doté, Joël Wilfried ; Gumede, Nicksy ; Vignuzzi, Marco ; Bessaud, Maël ; ... More +

Joffret, Marie-Line ; Doté, Joël Wilfried ; Gumede, Nicksy ; Vignuzzi, Marco ; Bessaud, Maël ; Gouandjika-Vasilache, Ionela Less -
Description:

Since May 2019, the Central African Republic has experienced a poliomyelitis outbreak caused by type 2 vaccine-derived polioviruses (VDPV-2s). The outbreak affected Bangui, the capital city, and 10 districts across the country. The outbreak resulted from several independent emergence events of VDPV-2s featuring recombinant genomes with complex mosaic genomes. The low number of mutations (<20) in the viral capsid protein 1-encoding region compared with the vaccine strain suggests that VDPV-2 had been circulating for a relatively short time (probably <3 years) before being isolated. Environmental surveillance, which relies on a limited number of sampling sites in the Central African Republic and does not cover the whole country, failed to detect the circulation of VDPV-2s before some had induced poliomyelitis in children.
Subjects:

[+]

Child Disease Outbreaks Humans Poliomyelitis/epidemiology Poliomyelitis/prevention & Control Poliovirus Poliovirus Vaccine, Oral/adverse Effects
Source:

Emerg Infect Dis. 27(2):620-623
Pubmed ID:

33496226
Pubmed Central ID:

PMC7853572
Document Type:

Journal Article
Place as Subject:

Central African Republic
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:816e4eaf5e430858a5c3a71dbb76b31487683b959530e76cfd7479f7ddbd6dc9
Download URL:

https://stacks.cdc.gov/view/cdc/102463/cdc_102463_DS1.pdf
File Type:

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