Prolonged Maternal Zika Viremia as a Marker of Adverse Perinatal Outcomes

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Pomar, Léo ; Lambert, Véronique ; Matheus, Séverine ; Pomar, Céline ; Hcini, Najeh ; Carles, Gabriel ; Rousset, Dominique ; Vouga, Manon ; Panchaud, Alice ; Baud, David
• Description:
  Whether prolonged maternal viremia after Zika virus infection represents a risk factor for maternal-fetal transmission and subsequent adverse outcomes remains unclear. In this prospective cohort study in French Guiana, we enrolled Zika virus-infected pregnant women with a positive PCR result at inclusion and noninfected pregnant women; both groups underwent serologic testing in each trimester and at delivery during January-July 2016. Prolonged viremia was defined as ongoing virus detection >30 days postinfection. Adverse outcomes (fetal loss or neurologic anomalies) were more common in fetuses and neonates from mothers with prolonged viremia (40.0%) compared with those from infected mothers without prolonged viremia (5.3%, adjusted relative risk [aRR] 7.2 [95% CI 0.9-57.6]) or those from noninfected mothers (6.6%, aRR 6.7 [95% CI 3.0-15.1]). Congenital infections were confirmed more often in fetuses and neonates from mothers with prolonged viremia compared with the other 2 groups (60.0% vs. 26.3% vs. 0.0%, aRR 2.3 [95% CI 0.9-5.5]).
• Subjects:
  Congenital Infection Congenital Zika Syndrome French Guiana Mosquitoborne Diseases Prolonged Maternal Zika Viremia As A Marker Of Adverse Perinatal Outcomes Prolonged Viremia Research Vector-borne Infections Viruses Zika Zika Virus ZIKV

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• Source:
  Emerg Infect Dis. 27(2):490-498
• Pubmed ID:
  33496246
• Pubmed Central ID:
  PMC7853546
• Document Type:
  Journal Article
• Volume:
  27
• Issue:
  2
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:835942c2d0e08a8df0b3c59df0f9306789e97776bc75b72ff3a668417c35e63f
• Download URL:
  https://stacks.cdc.gov/view/cdc/102443/cdc_102443_DS1.pdf
• File Type:
  [PDF - 2.10 MB ]