Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Pomar, Léo ; Lambert, Véronique ; Matheus, Séverine ; Pomar, Céline ; Hcini, Najeh ; ... More +
Pomar, Léo ; Lambert, Véronique ; Matheus, Séverine ; Pomar, Céline ; Hcini, Najeh ; Carles, Gabriel ; Rousset, Dominique ; Vouga, Manon ; Panchaud, Alice ; Baud, David Less -
Description:
Whether prolonged maternal viremia after Zika virus infection represents a risk factor for maternal-fetal transmission and subsequent adverse outcomes remains unclear. In this prospective cohort study in French Guiana, we enrolled Zika virus-infected pregnant women with a positive PCR result at inclusion and noninfected pregnant women; both groups underwent serologic testing in each trimester and at delivery during January-July 2016. Prolonged viremia was defined as ongoing virus detection >30 days postinfection. Adverse outcomes (fetal loss or neurologic anomalies) were more common in fetuses and neonates from mothers with prolonged viremia (40.0%) compared with those from infected mothers without prolonged viremia (5.3%, adjusted relative risk [aRR] 7.2 [95% CI 0.9-57.6]) or those from noninfected mothers (6.6%, aRR 6.7 [95% CI 3.0-15.1]). Congenital infections were confirmed more often in fetuses and neonates from mothers with prolonged viremia compared with the other 2 groups (60.0% vs. 26.3% vs. 0.0%, aRR 2.3 [95% CI 0.9-5.5]).
Subject:
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Congenital Infection Congenital Zika Syndrome French Guiana Mosquitoborne Diseases Prolonged Maternal Zika Viremia As A Marker Of Adverse Perinatal Outcomes Prolonged Viremia Research Vector-borne Infections Viruses Zika Zika Virus ZIKV
Source:
Emerg Infect Dis. 27(2):490-498
Pubmed ID:
33496246
Pubmed Central ID:
PMC7853546
Document Type:
Journal Article
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
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urn:sha256:835942c2d0e08a8df0b3c59df0f9306789e97776bc75b72ff3a668417c35e63f
Download URL:
https://stacks.cdc.gov/view/cdc/102443/cdc_102443_DS1.pdf
File Type:

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