The accuracy of provider diagnosed diabetes type in youth compared to an etiologic criteria in the SEARCH for Diabetes in Youth Study

Details

• Alternative Title:
  Pediatr Diabetes
• Personal Author:
  Crume, Tessa L. ; Hamman, Richard F. ; Isom, Scott ; Divers, Jasmin ; Mayer-Davis, Elizabeth J. ; Liese, Angela D. ; Saydah, Sharon ; Lawrence, Jean M. ; Pihoker, Catherine ; Dabelea, Dana
• Corporate Authors:
  SEARCH for Diabetes in Youth Study Group
• Description:
  Background:
  
  Although surveillance for diabetes in youth relies on provider-assigned diabetes type from medical records, its accuracy compared to an etiologic definition is unknown.
  
  Methods:
  
  Using the SEARCH for Diabetes in Youth Registry, we evaluated the validity and accuracy of provider-assigned diabetes type abstracted from medical records against etiologic criteria that included the presence of diabetes autoantibodies (DAA) and insulin sensitivity. Youth who were incident for diabetes in 2002–06, 2008, or 2012 and had complete data on key analysis variables were included (n=4,001, 85% provider diagnosed type 1). The etiologic definition for type 1 diabetes was ≥1 positive DAA titer(s) or negative DAA titers in the presence of insulin sensitivity and for type 2 diabetes was negative DAA titers in the presence of insulin resistance.
  
  Results:
  
  Provider diagnosed diabetes type correctly agreed with the etiologic definition of type for 89.9% of cases. Provider diagnosed type 1 diabetes was 96.9% sensitive, 82.8% specific, had a positive predictive value (PPV) of 97.0% and a negative predictive value (NPV) of 82.7%. Provider diagnosed type 2 diabetes was 82.8% sensitive, 96.9% specific, had a PPV and NPV of 82.7% and 97.0%, respectively.
  
  Conclusion:
  
  Provider diagnosis of diabetes type agreed with etiologic criteria for 90% of the cases. While the sensitivity and PPV were high for youth with type 1 diabetes, the lower sensitivity and PPV for type 2 diabetes highlights the value of DAA testing and assessment of insulin sensitivity status to ensure estimates are not biased by misclassification.
  
  
• Subjects:
  Article Diabetes Autoantibodies Surveillance Type 1 Diabetes Type 2 Diabetes Validity
• Source:
  Pediatr Diabetes. 21(8):1403-1411
• Pubmed ID:
  32981196
• Pubmed Central ID:
  PMC7819667
• Document Type:
  Journal Article
• Funding:
  U18 DP006134/DP/NCCDPHP CDC HHS/United States ; UL1 TR000154/TR/NCATS NIH HHS/United States ; U48/CCU819241-3/CC/CDC HHS/United States ; U01 DP000244/DP/NCCDPHP CDC HHS/United States ; UL1 TR000062/TR/NCATS NIH HHS/United States ; U18DP006134/ACL/ACL HHS/United States ; PA 00097/CC/CDC HHS/United States ; UL1 TR001425/TR/NCATS NIH HHS/United States ; U18DP006139/CC/CDC HHS/United States ; U18DP006138/CC/CDC HHS/United States ; U48/CCU519239/CC/CDC HHS/United States ; 1UC4DK108173/DK/NIDDK NIH HHS/United States ; P30 DK057516/DK/NIDDK NIH HHS/United States ; U18DP006139/ACL/ACL HHS/United States ; UC4 DK108173/DK/NIDDK NIH HHS/United States ; U01 DP000247/DP/NCCDPHP CDC HHS/United States ; U18 DP006131/DP/NCCDPHP CDC HHS/United States ; U18 DP002710/DP/NCCDPHP CDC HHS/United States ; UL1 TR00423/TR/NCATS NIH HHS/United States ; U18 DP006138/DP/NCCDPHP CDC HHS/United States ; 200-2010-35 171/CC/CDC HHS/United States ; U48/CCU919219/CC/CDC HHS/United States ; U18DP006138/ACL/ACL HHS/United States ; U18 DP002714/DP/NCCDPHP CDC HHS/United States ; U18DP006134/CC/CDC HHS/United States ; UL1 Tr001450/TR/NCATS NIH HHS/United States ; U01 DP000248/DP/NCCDPHP CDC HHS/United States ; U18DP002714/CC/CDC HHS/United States ; U48/CCU419249/CC/CDC HHS/United States ; 1U18DP002709/CC/CDC HHS/United States ; U58/CCU019235-4/CC/CDC HHS/United States ; U18DP002710-01/CC/CDC HHS/United States ; U18 DP006136/DP/NCCDPHP CDC HHS/United States ; U18 DP002709/DP/NCCDPHP CDC HHS/United States ; U18 DP006133/DP/NCCDPHP CDC HHS/United States ; U18DP006136/CC/CDC HHS/United States ; U18DP006131/ACL/ACL HHS/United States ; DP-10-001/CC/CDC HHS/United States ; U18 DP006139/DP/NCCDPHP CDC HHS/United States ; U18DP006133/CC/CDC HHS/United States ; UL1 TR000077/TR/NCATS NIH HHS/United States ; DP-05-069/CC/CDC HHS/United States ; R01 DK127208/DK/NIDDK NIH HHS/United States ; 1U18DP006131/CC/CDC HHS/United States ; UL1 TR000423/TR/NCATS NIH HHS/United States ; U18DP006136/ACL/ACL HHS/United States ; U18DP000247-06A1/CC/CDC HHS/United States ; U01 DP000250/DP/NCCDPHP CDC HHS/United States ; U01 DP000246/DP/NCCDPHP CDC HHS/United States ; U01 DP000254/DP/NCCDPHP CDC HHS/United States ; U18DP006133/ACL/ACL HHS/United States ; U18 DP002708/DP/NCCDPHP CDC HHS/United States ; HIR 10-001/HX/HSRD VA/United States ; U18DP002708/CC/CDC HHS/United States
• Volume:
  21
• Issue:
  8
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:c5e6820e602b92a335d46b7d38003b1be0855e37ac8c03166b8052fe10b27dc2
• Download URL:
  https://stacks.cdc.gov/view/cdc/101071/cdc_101071_DS1.pdf
• File Type:
  [PDF - 591.66 KB ]