High hsCRP Is Associated With Reduced Lung Function in Structural Firefighters

Details

• Alternative Title:
  Am J Ind Med
• Personal Author:
  Gaughan, Denise M. ; Christiani, David C. ; Hughes, Michael D. ; Baur, Dorothee M. ; Kobzik, Lester ; Wagner, Gregory R. ; Kales, Stefanos N.
• Description:
  Background
  
  To assess the association between markers of systemic inflammation and pulmonary function in a population of structural firefighters.
  
  Methods
  
  We studied male career members of a large Midwestern fire department with questionnaires, spirometry, and high-sensitivity C-reactive protein (hsCRP) as a biomarker of systemic inflammation. We examined percent predicted forced expiratory volume in 1s (FEV1%-predicted) and forced vital capacity (FVC%-predicted).
  
  Results
  
  Complete data were available for 401 firefighters. Higher hsCRP levels were associated with lower lung function values, after adjusting for confounding variables. Specifically, for every twofold increase in log10-hsCRP, FEV1%-predicted decreased by a mean 1.5% (95% CI: 0.4, 2.6%) and FVC%-predicted decreased by a mean 1.4% (95% CI: 0.4, 2.3%).
  
  Conclusion
  
  hsCRP as a biomarker of systemic inflammation may indicate reduced lung function in structural firefighters.
  
  
• Subjects:
  Adult Article Biomarkers C-Reactive Protein Firefighters Fires Forced Expiratory Volume High-sensitivity C-reactive Protein (hsCRP) Humans Inflammation Lung Male Middle Aged Occupational Exposure Percent Predicted Forced Expiratory Volume In 1s (FEV1%-predicted) Percent Predicted Forced Vital Capacity (FVC%-predicted) Physical Fitness Spirometry Surveys And Questionnaires Vital Capacity

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• Source:
  Am J Ind Med. 57(1):31-37
• Pubmed ID:
  24115029
• Pubmed Central ID:
  PMC7786395
• Document Type:
  Journal Article
• Funding:
  P30 ES000002/ES/NIEHS NIH HHS/United States ; T42 OH008416/OH/NIOSH CDC HHS/United States
• Volume:
  57
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:0bfcc65c8d47d0174e86c999814fb086baade5ed93f56169787eec35e503ebae
• Download URL:
  https://stacks.cdc.gov/view/cdc/100396/cdc_100396_DS1.pdf
• File Type:
  [PDF - 142.90 KB ]