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High hsCRP Is Associated With Reduced Lung Function in Structural Firefighters
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September 20 2013
Source: Am J Ind Med. 57(1):31-37
Details:
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Alternative Title:Am J Ind Med
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Description:Background
To assess the association between markers of systemic inflammation and pulmonary function in a population of structural firefighters.
Methods
We studied male career members of a large Midwestern fire department with questionnaires, spirometry, and high-sensitivity C-reactive protein (hsCRP) as a biomarker of systemic inflammation. We examined percent predicted forced expiratory volume in 1s (FEV1%-predicted) and forced vital capacity (FVC%-predicted).
Results
Complete data were available for 401 firefighters. Higher hsCRP levels were associated with lower lung function values, after adjusting for confounding variables. Specifically, for every twofold increase in log10-hsCRP, FEV1%-predicted decreased by a mean 1.5% (95% CI: 0.4, 2.6%) and FVC%-predicted decreased by a mean 1.4% (95% CI: 0.4, 2.3%).
Conclusion
hsCRP as a biomarker of systemic inflammation may indicate reduced lung function in structural firefighters.
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Source:
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Pubmed ID:24115029
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Pubmed Central ID:PMC7786395
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