High hsCRP is associated with reduced lung function in structural firefighters

Details

• Personal Author:
  Baur DM ; Christiani, David C. ; Gaughan, Denise M. ; Hughes MD ; Kales SN ; Kobzik L ; Wagner, Gregory R.
• Description:
  Background: To assess the association between markers of systemic inflammation and pulmonary function in a population of structural firefighters. Methods: We studied male career members of a large Midwestern fire department with questionnaires, spirometry, and high-sensitivity C-reactive protein (hsCRP) as a biomarker of systemic inflammation. We examined percent predicted forced expiratory volume in 1s (FEV1%-predicted) and forced vital capacity (FVC%-predicted). Results: Complete data were available for 401 firefighters. Higher hsCRP levels were associated with lower lung function values, after adjusting for confounding variables. Specifically, for every twofold increase in log10-hsCRP, FEV1%-predicted decreased by a mean 1.5% (95% CI: 0.4, 2.6%) and FVC%-predicted decreased by a mean 1.4% (95% CI: 0.4, 2.3%). Conclusion: hsCRP as a biomarker of systemic inflammation may indicate reduced lung function in structural firefighters. [Description provided by NIOSH]
• Subjects:
  Biomarkers Firefighters Lung Men Occupational Health Respiratory Function Tests Respiratory System Respiratory Tract Diseases Safety Surveys And Questionnaires
• Keywords:
  Author Keywords: Percent Predicted Forced Expiratory Volume In 1 S FEV1%-predicted Fire-fighters FVC%-predicted High-sensitivity C-reactive Protein HsCRP Humans Lung-function Percent Predicted Forced Vital Capacity Proteins Pulmonary-function Pulmonary-system Pulmonary-system-disorders Questionnaires Spirometry Statistical-analysis

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• ISSN:
  0271-3586
• Document Type:
  Text
• Funding:
  Grant
• Genre:
  Journal Article
• Place as Subject:
  Massachusetts ; New York ; OSHA Region 1 ; OSHA Region 2
• CIO:
  National Institute for Occupational Safety and Health (NIOSH)
• Division:
  OD - Office of the Director
• Topic:
  Workplace Safety & Health
• Location:
  North America
• Pages in Document:
  31-37
• Volume:
  57
• Issue:
  1
• NIOSHTIC Number:
  nn:20043515
• Citation:
  Am J Ind Med 2014 Jan; 57(1):31-37
• Contact Point Address:
  Stefanos N. Kales, Department of Environmental Health (Environmental and Occupational Medicine and Epidemiology Program), Building 1, Room1407, Harvard School of Public Health, Boston, MA
• Email:
  skales@hsph.harvard.edu
• Federal Fiscal Year:
  2014
• Performing Organization:
  Harvard School of Public Health
• Peer Reviewed:
  True
• Start Date:
  20050701
• Source Full Name:
  American Journal of Industrial Medicine
• End Date:
  20280630
• Collection(s):
  National Institute for Occupational Safety and Health
• Main Document Checksum:
  urn:sha-512:8f652a05f0f09bbd25fad56432434ba2562d1de7f25326a62f706c9ad9caeef4b88aed7d182768015c0a683bffa223e817defb33b715807eabd557d5c5a54f1d
• Download URL:
  https://stacks.cdc.gov/view/cdc/195401/cdc_195401_DS1.pdf
• File Type:
  [PDF - 186.47 KB ]