Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Gallais, Floriane ; Velay, Aurélie ; Nazon, Charlotte ; Wendling, Marie-Josée ; Partisani, Marialuisa ; ... More +
Gallais, Floriane ; Velay, Aurélie ; Nazon, Charlotte ; Wendling, Marie-Josée ; Partisani, Marialuisa ; Sibilia, Jean ; Candon, Sophie ; Fafi-Kremer, Samira ; Less -
Description:
We investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies and T-cell responses against SARS-CoV-2 and human coronavirus (HCoV) 229E and OC43 in 11 SARS-CoV-2 serodiscordant couples in Strausbourg, France, in which 1 partner had evidence of mild coronavirus disease (COVID-19) and in 10 unexposed healthy controls. Patients with confirmed COVID-19 were considered index patients and their partners close contacts. All index patients displayed positive SARS-CoV-2-specific antibody and T-cell responses that lasted up to 102 days after symptom onset. All contacts remained seronegative for SARS-CoV-2; however, 6 reported COVID-19 symptoms within a median of 7 days after their partners, and 4 of those showed a positive SARS-CoV-2-specific T-cell response against 3 or 4 SARS-CoV-2 antigens that lasted up to 93 days after symptom onset. The 11 couples and controls displayed positive T-cell responses against HCoV-229E or HCoV-OC43. These data suggest that exposure to SARS-CoV-2 can induce virus-specific T-cell responses without seroconversion.
Subject:
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Adult
Aged
Antibodies, Viral
Case-Control Studies
Coronavirus Infections
COVID-19 Testing
Family
Female
Humans
Immunity, Cellular
Male
Middle Aged
Seroconversion
Serologic Tests
T-Lymphocytes

Source:
Emerg Infect Dis. 27(1):113-121 ;
Pubmed ID:
33261718
Pubmed Central ID:
PMC7774579
Document Type:
Journal Article ;
Place as Subject:
France ;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:eb696963710e81862895819f0c1fc99d2146cc18a4406a749b1d55b034ae3e05
File Type:

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