Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France

Gallais, Floriane; Velay, Aurélie; Nazon, Charlotte; Wendling, Marie-Josée; Partisani, Marialuisa; Sibilia, Jean; Candon, Sophie; Fafi-Kremer, Samira

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Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France

Published Date:

December 01 2020

Source:

Emerg Infect Dis. 27(1):113-121

Language:

English

[PDF-1.71 MB]

Details:

Alternative Title:

Emerg Infect Dis

Personal Author:

Gallais, Floriane ; Velay, Aurélie ; Nazon, Charlotte ; Wendling, Marie-Josée ; Partisani, Marialuisa ; ... More ▼

Description:

We investigated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies and T-cell responses against SARS-CoV-2 and human coronavirus (HCoV) 229E and OC43 in 11 SARS-CoV-2 serodiscordant couples in Strausbourg, France, in which 1 partner had evidence of mild coronavirus disease (COVID-19) and in 10 unexposed healthy controls. Patients with confirmed COVID-19 were considered index patients and their partners close contacts. All index patients displayed positive SARS-CoV-2-specific antibody and T-cell responses that lasted up to 102 days after symptom onset. All contacts remained seronegative for SARS-CoV-2; however, 6 reported COVID-19 symptoms within a median of 7 days after their partners, and 4 of those showed a positive SARS-CoV-2-specific T-cell response against 3 or 4 SARS-CoV-2 antigens that lasted up to 93 days after symptom onset. The 11 couples and controls displayed positive T-cell responses against HCoV-229E or HCoV-OC43. These data suggest that exposure to SARS-CoV-2 can induce virus-specific T-cell responses without seroconversion.

Subject:

[+]

Pubmed ID:

33261718

Pubmed Central ID:

PMC7774579

Document Type:

Journal Article

Place as Subject:

France

Collection(s):

Emerging Infectious Diseases

Main Document Checksum:

[+]

File Type:

Supporting Files:

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Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France

Intrafamilial Exposure to SARS-CoV-2 Associated with Cellular Immune Response without Seroconversion, France

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