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Engineered CRISPR-Cas9 nucleases with altered PAM specificities

CITE Title : Engineered CRISPR-Cas9 nucleases with altered PAM specificities Personal Author(s) : Kleinstiver, Benjamin P.;Prew, Michelle S.;Tsai, Shengdar Q.;Topkar, Ved;Nguyen, Nhu T.;Zheng, Zongli;Gonzales, Andrew P.W.;Li, Zhuyun;Peterson, Randall T.;Yeh, Jing-Ruey Joanna;Aryee, Martin J.;Joung, J. Keith; Published Date : Jun 22 2015 Source : Nature. 523(7561):481-485. URL : https://stacks.cdc.gov/view/cdc/32948 Kleinstiver, Benjamin P. et al. (2015). Engineered CRISPR-Cas9 nucleases with altered PAM specificities. 523(7561). Kleinstiver, Benjamin P. et al. "Engineered CRISPR-Cas9 nucleases with altered PAM specificities" 523, no. 7561 (2015) Kleinstiver, Benjamin P. et al. "Engineered CRISPR-Cas9 nucleases with altered PAM specificities" vol. 523, no. 7561, 2015 Export RIS Citation Information.

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Kleinstiver, Benjamin P. ;

Prew, Michelle S.

Jun 22 2015 | Nature. 523(7561):481-485.

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Although CRISPR-Cas9 nucleases are widely used for genome editing, the range of sequences that Cas9 can recognize is constrained by the need for a spe...
Continuous directed evolution of DNA-binding proteins to improve TALEN specificity

CITE Title : Continuous directed evolution of DNA-binding proteins to improve TALEN specificity Personal Author(s) : Hubbard, Basil P.;Badran, Ahmed H.;Zuris, John A.;Guilinger, John P.;Davis, Kevin M.;Chen, Liwei;Tsai, Shengdar Q.;Sander, Jeffry D.;Joung, J. Keith;Liu, David R.; Published Date : Aug 10 2015 Source : Nat Methods. 12(10):939-942. URL : https://stacks.cdc.gov/view/cdc/36969 Hubbard, Basil P. et al. (2015). Continuous directed evolution of DNA-binding proteins to improve TALEN specificity. 12(10). Hubbard, Basil P. et al. "Continuous directed evolution of DNA-binding proteins to improve TALEN specificity" 12, no. 10 (2015) Hubbard, Basil P. et al. "Continuous directed evolution of DNA-binding proteins to improve TALEN specificity" vol. 12, no. 10, 2015 Export RIS Citation Information.

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Hubbard, Basil P. ;

Badran, Ahmed H.

Aug 10 2015 | Nat Methods. 12(10):939-942.

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Nucleases containing programmable DNA-binding domains can alter the genomes of model organisms and have the potential to become human therapeutics. He...
Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli

CITE Title : Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli Personal Author(s) : Goodarzi, Hani;Bennett, Bryson D;Amini, Sasan;Reaves, Marshall L;Hottes, Alison K;Rabinowitz, Joshua D;Tavazoie, Saeed; Published Date : Jun 8 2010 Source : Mol Syst Biol. 2010; 6:378. URL : https://stacks.cdc.gov/view/cdc/22897 Goodarzi, Hani et al. (2010). Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli. 6 Goodarzi, Hani et al. "Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli" 6 (2010) Goodarzi, Hani et al. "Regulatory and metabolic rewiring during laboratory evolution of ethanol tolerance in E. coli" vol. 6, 2010 Export RIS Citation Information.

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Goodarzi, Hani ;

Bennett, Bryson D

Jun 8 2010 | Mol Syst Biol. 2010; 6:378.

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Understanding the genetic basis of adaptation is a central problem in biology. However, revealing the underlying molecular mechanisms has been challen...
Fitness Landscape Transformation through a Single Amino Acid Change in the Rho Terminator

CITE Title : Fitness Landscape Transformation through a Single Amino Acid Change in the Rho Terminator Personal Author(s) : Freddolino, Peter L.;Goodarzi, Hani;Tavazoie, Saeed; Published Date : May 31 2012 Source : PLoS Genet. 2012; 8(5). URL : https://stacks.cdc.gov/view/cdc/22745 Freddolino, Peter L. et al. (2012). Fitness Landscape Transformation through a Single Amino Acid Change in the Rho Terminator. 8(5). Freddolino, Peter L. and Goodarzi, Hani and Tavazoie, Saeed "Fitness Landscape Transformation through a Single Amino Acid Change in the Rho Terminator" 8, no. 5 (2012) Freddolino, Peter L. et al. "Fitness Landscape Transformation through a Single Amino Acid Change in the Rho Terminator" vol. 8, no. 5, 2012 Export RIS Citation Information.

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Freddolino, Peter L. ;

Goodarzi, Hani

May 31 2012 | PLoS Genet. 2012; 8(5).

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Regulatory networks allow organisms to match adaptive behavior to the complex and dynamic contingencies of their native habitats. Upon a sudden transi...
Bacterial Adaptation through Loss of Function

CITE Title : Bacterial Adaptation through Loss of Function Personal Author(s) : Hottes, Alison K.;Freddolino, Peter L.;Khare, Anupama;Donnell, Zachary N.;Liu, Julia C.;Tavazoie, Saeed; Published Date : Jul 11 2013 Source : PLoS Genet. 2013; 9(7). URL : https://stacks.cdc.gov/view/cdc/22591 Hottes, Alison K. et al. (2013). Bacterial Adaptation through Loss of Function. 9(7). Hottes, Alison K. et al. "Bacterial Adaptation through Loss of Function" 9, no. 7 (2013) Hottes, Alison K. et al. "Bacterial Adaptation through Loss of Function" vol. 9, no. 7, 2013 Export RIS Citation Information.

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Hottes, Alison K. ;

Freddolino, Peter L.

Jul 11 2013 | PLoS Genet. 2013; 9(7).

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The metabolic capabilities and regulatory networks of bacteria have been optimized by evolution in response to selective pressures present in each spe...