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Hypoxia as a Therapy for Mitochondrial Disease

CITE Title : Hypoxia as a Therapy for Mitochondrial Disease Personal Author(s) : Jain, Isha H.;Zazzeron, Luca;Goli, Rahul;Alexa, Kristen;Schatzman-Bone, Stephanie;Dhillon, Harveen;Goldberger, Olga;Peng, Jun;Shalem, Ophir;Sanjana, Neville E.;Zhang, Feng;Goessling, Wolfram;Zapol, Warren M.;Mootha, Vamsi K.; Published Date : February 25 2016;4-1-; Source : Science. 352(6281):54-61 URL : https://stacks.cdc.gov/view/cdc/39440 Jain, Isha H. et al. (2016). Hypoxia as a Therapy for Mitochondrial Disease. 352(6281). Jain, Isha H. et al. "Hypoxia as a Therapy for Mitochondrial Disease" 352, no. 6281 (2016) Jain, Isha H. et al. "Hypoxia as a Therapy for Mitochondrial Disease" vol. 352, no. 6281, 2016 Export RIS Citation Information.

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Jain, Isha H. ;

Zazzeron, Luca

February 25 2016 | Science. 352(6281):54-61

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Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to a...
Discovery and functional characterization of diverse Class 2 CRISPR-Cas systems

CITE Title : Discovery and functional characterization of diverse Class 2 CRISPR-Cas systems Personal Author(s) : Shmakov, Sergey;Abudayyeh, Omar O.;Makarova, Kira S.;Wolf, Yuri I;Gootenberg, Jonathan S.;Semenova, Ekaterina;Minakhin, Leonid;Joung, Julia;Konermann, Silvana;Severinov, Konstantin;Zhang, Feng;Koonin, Eugene V.; Published Date : Oct 22 2015 Source : Mol Cell. 60(3):385-397. URL : https://stacks.cdc.gov/view/cdc/37888 Shmakov, Sergey et al. (2015). Discovery and functional characterization of diverse Class 2 CRISPR-Cas systems. 60(3). Shmakov, Sergey et al. "Discovery and functional characterization of diverse Class 2 CRISPR-Cas systems" 60, no. 3 (2015) Shmakov, Sergey et al. "Discovery and functional characterization of diverse Class 2 CRISPR-Cas systems" vol. 60, no. 3, 2015 Export RIS Citation Information.

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Shmakov, Sergey ;

Abudayyeh, Omar O.

Oct 22 2015 | Mol Cell. 60(3):385-397.

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Microbial CRISPR-Cas systems are divided into Class 1, with multisubunit effector complexes, and Class 2, with single protein effectors. Currently, on...
In vivo gene editing in dystrophic mouse muscle and muscle stem cells#

CITE Title : In vivo gene editing in dystrophic mouse muscle and muscle stem cells# Personal Author(s) : Tabebordbar, Mohammadsharif;Zhu, Kexian;Cheng, Jason K.W.;Chew, Wei Leong;Widrick, Jeffrey J.;Yan, Winston X.;Maesner, Claire;Wu, Elizabeth Y.;Xiao, Ru;Ran, F. Ann;Cong, Le;Zhang, Feng;Vandenberghe, Luk H.;Church, George M.;Wagers, Amy J.; Published Date : Dec 31 2015 Source : Science. 351(6271):407-411. URL : https://stacks.cdc.gov/view/cdc/40098 Tabebordbar, Mohammadsharif et al. (2015). In vivo gene editing in dystrophic mouse muscle and muscle stem cells#. 351(6271). Tabebordbar, Mohammadsharif et al. "In vivo gene editing in dystrophic mouse muscle and muscle stem cells#" 351, no. 6271 (2015) Tabebordbar, Mohammadsharif et al. "In vivo gene editing in dystrophic mouse muscle and muscle stem cells#" vol. 351, no. 6271, 2015 Export RIS Citation Information.

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Tabebordbar, Mohammadsharif ;

Zhu, Kexian

Dec 31 2015 | Science. 351(6271):407-411.

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Frame-disrupting mutations in the DMD gene, encoding dystrophin, compromise myofiber integrity and drive muscle deterioration in Duchenne muscular dys...
In vivo genome editing using Staphylococcus aureus Cas9

CITE Title : In vivo genome editing using Staphylococcus aureus Cas9 Personal Author(s) : Ran, F. Ann;Cong, Le;Yan, Winston X.;Scott, David A.;Gootenberg, Jonathan S.;Kriz, Andrea J.;Zetsche, Bernd;Shalem, Ophir;Wu, Xuebing;Makarova, Kira S.;Koonin, Eugene;Sharp, Phillip A.;Zhang, Feng; Published Date : Apr 01 2015 Source : Nature. 520(7546):186-191. URL : https://stacks.cdc.gov/view/cdc/30379 Ran, F. Ann et al. (2015). In vivo genome editing using Staphylococcus aureus Cas9. 520(7546). Ran, F. Ann et al. "In vivo genome editing using Staphylococcus aureus Cas9" 520, no. 7546 (2015) Ran, F. Ann et al. "In vivo genome editing using Staphylococcus aureus Cas9" vol. 520, no. 7546, 2015 Export RIS Citation Information.

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Ran, F. Ann ;

Cong, Le

Apr 01 2015 | Nature. 520(7546):186-191.

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The RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform. However, the size of the commonly used Cas9 from Streptococcus py...
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

CITE Title : BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis Personal Author(s) : Canver, Matthew C.;Smith, Elenoe C.;Sher, Falak;Pinello, Luca;Sanjana, Neville E.;Shalem, Ophir;Chen, Diane D.;Schupp, Patrick G.;Vinjamur, Divya S.;Garcia, Sara P.;Luc, Sidinh;Kurita, Ryo;Nakamura, Yukio;Fujiwara, Yuko;Maeda, Takahiro;Yuan, Guo-Cheng;Feng, Zhang;Orkin, Stuart H.;Bauer, Daniel E.; Published Date : Sep 16 2015 Source : Nature. 527(7577):192-197. URL : https://stacks.cdc.gov/view/cdc/36479 Canver, Matthew C. et al. (2015). BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis. 527(7577). Canver, Matthew C. et al. "BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis" 527, no. 7577 (2015) Canver, Matthew C. et al. "BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis" vol. 527, no. 7577, 2015 Export RIS Citation Information.

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Canver, Matthew C. ;

Smith, Elenoe C.

Sep 16 2015 | Nature. 527(7577):192-197.

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Enhancers, critical determinants of cellular identity, are commonly recognized by correlative chromatin marks and gain-of-function potential, although...
Rationally engineered Cas9 nucleases with improved specificity

CITE Title : Rationally engineered Cas9 nucleases with improved specificity Personal Author(s) : Slaymaker, Ian M.;Gao, Linyi;Zetsche, Bernd;Scott, David A.;Yan, Winston X.;Zhang, Feng; Published Date : Dec 01 2015 Source : Science. 351(6268):84-88. URL : https://stacks.cdc.gov/view/cdc/37554 Slaymaker, Ian M. et al. (2015). Rationally engineered Cas9 nucleases with improved specificity. 351(6268). Slaymaker, Ian M. et al. "Rationally engineered Cas9 nucleases with improved specificity" 351, no. 6268 (2015) Slaymaker, Ian M. et al. "Rationally engineered Cas9 nucleases with improved specificity" vol. 351, no. 6268, 2015 Export RIS Citation Information.

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Slaymaker, Ian M. ;

Gao, Linyi

Dec 01 2015 | Science. 351(6268):84-88.

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The RNA-guided endonuclease Cas9 is a versatile genome-editing tool with a broad range of applications from therapeutics to functional annotation of g...
Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

CITE Title : Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA Personal Author(s) : Nishimasu, Hiroshi;Ran, F. Ann;Hsu, Patrick D.;Konermann, Silvana;Shehata, Soraya;Dohmae, Naoshi;Ishitani, Ryuichiro;Zhang, Feng;Nureki, Osamu; Published Date : Feb 13 2014 Source : Cell. 156(5):935-949. URL : https://stacks.cdc.gov/view/cdc/30086 Nishimasu, Hiroshi et al. (2014). Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA. 156(5). Nishimasu, Hiroshi et al. "Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA" 156, no. 5 (2014) Nishimasu, Hiroshi et al. "Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA" vol. 156, no. 5, 2014 Export RIS Citation Information.

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Nishimasu, Hiroshi ;

Ran, F. Ann

Feb 13 2014 | Cell. 156(5):935-949.

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The CRISPR-associated endonuclease Cas9 can be targeted to specific genomic loci by single guide RNAs (sgRNAs). Here, we report the crystal structure ...
A genome-wide CRISPR screen in primary immune cells to dissect regulatory networks

CITE Title : A genome-wide CRISPR screen in primary immune cells to dissect regulatory networks Personal Author(s) : Parnas, Oren;Jovanovic, Marko;Eisenhaure, Thomas M.;Herbst, Rebecca H.;Dixit, Atray;Ye, Chun Jimmie;Przybylski, Dariusz;Platt, Randall J.;Tirosh, Itay;Sanjana, Neville E.;Shalem, Ophir;Satija, Rahul;Raychowdhury, Raktima;Mertins, Philipp;Carr, Steven A.;Zhang, Feng;Hacohen, Nir;Regev, Aviv; Published Date : Jul 16 2015 Source : Cell. 162(3):675-686. URL : https://stacks.cdc.gov/view/cdc/34824 Parnas, Oren et al. (2015). A genome-wide CRISPR screen in primary immune cells to dissect regulatory networks. 162(3). Parnas, Oren et al. "A genome-wide CRISPR screen in primary immune cells to dissect regulatory networks" 162, no. 3 (2015) Parnas, Oren et al. "A genome-wide CRISPR screen in primary immune cells to dissect regulatory networks" vol. 162, no. 3, 2015 Export RIS Citation Information.

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Parnas, Oren ;

Jovanovic, Marko

Jul 16 2015 | Cell. 162(3):675-686.

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Finding the components of cellular circuits and determining their functions systematically remains a major challenge in mammalian cells. Here, we intr...
Applications of CRISPR-Cas systems in neuroscience

CITE Title : Applications of CRISPR-Cas systems in neuroscience Personal Author(s) : Heidenreich, Matthias;Zhang, Feng; Published Date : Dec 10 2015 Source : Nat Rev Neurosci. 17(1):36-44. URL : https://stacks.cdc.gov/view/cdc/39857 Heidenreich, Matthias and Zhang, Feng (2015). Applications of CRISPR-Cas systems in neuroscience. 17(1). Heidenreich, Matthias and Zhang, Feng "Applications of CRISPR-Cas systems in neuroscience" 17, no. 1 (2015) Heidenreich, Matthias and Zhang, Feng "Applications of CRISPR-Cas systems in neuroscience" vol. 17, no. 1, 2015 Export RIS Citation Information.

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Heidenreich, Matthias ;

Zhang, Feng

Dec 10 2015 | Nat Rev Neurosci. 17(1):36-44.

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Genome-editing tools, and in particular those based on CRISPR-Cas (clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated...
Structure and Engineering of Francisella novicida Cas9

CITE Title : Structure and Engineering of Francisella novicida Cas9 Personal Author(s) : Hirano, Hisato;Gootenberg, Jonathan S.;Horii, Takuro;Abudayyeh, Omar O.;Kimura, Mika;Hsu, Patrick D.;Nakane, Takanori;Ishitani, Ryuichiro;Hatada, Izuho;Zhang, Feng;Nishimasu, Hiroshi;Nureki, Osamu; Published Date : Feb 11 2016 Source : Cell. 164(5):950-961. URL : https://stacks.cdc.gov/view/cdc/40093 Hirano, Hisato et al. (2016). Structure and Engineering of Francisella novicida Cas9. 164(5). Hirano, Hisato et al. "Structure and Engineering of Francisella novicida Cas9" 164, no. 5 (2016) Hirano, Hisato et al. "Structure and Engineering of Francisella novicida Cas9" vol. 164, no. 5, 2016 Export RIS Citation Information.

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Hirano, Hisato ;

Gootenberg, Jonathan S.

Feb 11 2016 | Cell. 164(5):950-961.

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The RNA-guided endonuclease Cas9 cleaves double-stranded DNA targets complementary to the guide RNA and has been applied to programmable genome editin...
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

CITE Title : C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector Personal Author(s) : Abudayyeh, Omar O.;Gootenberg, Jonathan S.;Konermann, Silvana;Joung, Julia;Slaymaker, Ian M.;Cox, David B.T.;Shmakov, Sergey;Makarova, Kira S.;Semenova, Ekaterina;Minakhin, Leonid;Severinov, Konstantin;Regev, Aviv;Lander, Eric S.;Koonin, Eugene V.;Zhang, Feng; Published Date : Jun 02 2016 Source : Science. 353(6299):aaf5573. URL : https://stacks.cdc.gov/view/cdc/42943 Abudayyeh, Omar O. et al. (2016). C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector. 353(6299). Abudayyeh, Omar O. et al. "C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector" 353, no. 6299 (2016) Abudayyeh, Omar O. et al. "C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector" vol. 353, no. 6299, 2016 Export RIS Citation Information.

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Abudayyeh, Omar O. ;

Gootenberg, Jonathan S.

Jun 02 2016 | Science. 353(6299):aaf5573.

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The clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated genes (Cas) adaptive immune system defends microbes against fo...