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Showing 321 - 340 of 1970 results

Epidemiology of Human Metapneumovirus Among Children With Severe or Very Severe Pneumonia in High Pneumonia Burden Settings: the Pneumonia Etiology Research For Child Health (PERCH) Study Experience.

Miyakawa, Ryo ;

Zhang, Haijun

March 2025 | Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 2025, v. 31, no. 3

After respiratory syncytial virus (RSV), human metapneumovirus (hMPV) was the second-ranked pathogen attributed to severe pneumonia in the PERCH study. We sought to characterize hMPV-positive cases in high-burden settings, which have limited data, by comparing with RSV-positive and other cases.Children aged 1-59 months hospitalized with suspected s ...

10/10/2026

Supporting Files

Title : Epidemiology of Human Metapneumovirus Among Children With Severe or Very Severe Pneumonia in High Pneumonia Burden Settings: the Pneumonia Etiology Research For Child Health (PERCH) Study Experience. Personal Author(s) : Miyakawa, Ryo;Zhang, Haijun;Brooks, W. Abdullah;Prosperi, Christine;Baggett, Henry C.;Feikin, Daniel R.;Hammitt, Laura L.;Howie, Stephen R.C.;Kotloff, Karen L.;Levine, Orin S.;Madhi, Shabir A.;Murdoch, David R.;O'Brien, Katherine L.;Scott, J. Anthony G.;Thea, Donald M.;Antonio, Martin;Awori, Juliet O.;Bunthi, Charatdao;Driscoll, Amanda J.;Ebruke, Bernard;Fancourt, Nicholas S.;Higdon, Melissa M.;Karron, Ruth A.;Moore, David P.;Morpeth, Susan C.;Mulindwa, Justin M.;Park, Daniel E.;Rahman, Mohammed Ziaur;Rahman, Mustafizur;Salaudeen, Rasheed A.;Sawatwong, Pongpun;Seidenberg, Phil;Sow, Samba O.;Tapia, Milagritos D.;Knoll, Maria Deloria; Published Date : March 2025 Pages in Document : 441-450 (22 pdf pages) Source : Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 2025, v. 31, no. 3 DOI : https://doi.org/10.1016/j.cmi.2024.10.023 Journal Title : Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
Miyakawa, R., Zhang, H., Brooks, W. A., Prosperi, C., Baggett, H. C., Feikin, D. R., Hammitt, L. L., Howie, S. R., Kotloff, K. L., Levine, O. S., Madhi, S. A., Murdoch, D. R., O'Brien, K. L., Scott, J. A. G., Thea, D. M., Antonio, M., Awori, J. O., Bunthi, C., Driscoll, A. J., ... Knoll, M. D. (2025). Epidemiology of Human Metapneumovirus Among Children With Severe or Very Severe Pneumonia in High Pneumonia Burden Settings: the Pneumonia Etiology Research For Child Health (PERCH) Study Experience. Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 31(3). https://doi.org/10.1016/j.cmi.2024.10.023

Miyakawa, Ryo, Haijun Zhang, W. Abdullah Brooks, Christine Prosperi, Henry C. Baggett, Daniel R. Feikin, and Laura L. Hammitt, et al.. "Epidemiology of Human Metapneumovirus Among Children With Severe or Very Severe Pneumonia in High Pneumonia Burden Settings: the Pneumonia Etiology Research For Child Health (PERCH) Study Experience." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases 31, no. 3 (2025). https://doi.org/10.1016/j.cmi.2024.10.023.

Miyakawa, Ryo, et al. "Epidemiology of Human Metapneumovirus Among Children With Severe or Very Severe Pneumonia in High Pneumonia Burden Settings: the Pneumonia Etiology Research For Child Health (PERCH) Study Experience." Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, vol. 31, no. 3, 2025. Stacks. https://doi.org/10.1016/j.cmi.2024.10.023.
Export RIS Citation Information. TY - Journal Article AU - Miyakawa, Ryo AU - Zhang, Haijun AU - Brooks, W. Abdullah AU - Prosperi, Christine AU - Baggett, Henry C. AU - Feikin, Daniel R. AU - Hammitt, Laura L. AU - Howie, Stephen R.C. AU - Kotloff, Karen L. AU - Levine, Orin S. AU - Madhi, Shabir A. AU - Murdoch, David R. AU - O'Brien, Katherine L. AU - Scott, J. Anthony G. AU - Thea, Donald M. AU - Antonio, Martin AU - Awori, Juliet O. AU - Bunthi, Charatdao AU - Driscoll, Amanda J. AU - Ebruke, Bernard AU - Fancourt, Nicholas S. AU - Higdon, Melissa M. AU - Karron, Ruth A. AU - Moore, David P. AU - Morpeth, Susan C. AU - Mulindwa, Justin M. AU - Park, Daniel E. AU - Rahman, Mohammed Ziaur AU - Rahman, Mustafizur AU - Salaudeen, Rasheed A. AU - Sawatwong, Pongpun AU - Seidenberg, Phil AU - Sow, Samba O. AU - Tapia, Milagritos D. AU - Knoll, Maria Deloria AB - After respiratory syncytial virus (RSV), human metapneumovirus (hMPV) was the second-ranked pathogen attributed to severe pneumonia in the PERCH study. We sought to characterize hMPV-positive cases in high-burden settings, which have limited data, by comparing with RSV-positive and other cases. AB - Children aged 1-59 months hospitalized with suspected severe pneumonia and age/season-matched community controls in seven African and Asian countries had nasopharyngeal/oropharyngeal swabs tested by multiplex PCR for 32 respiratory pathogens, among other clinical and lab assessments at admission. Odds ratios adjusted for age and site (adjusted OR [aOR]) were calculated using logistic regression. Aetiologic probability was estimated using Bayesian nested partial latent class analysis. Latent class analysis identified syndromic constellations of clinical characteristics. AB - hMPV was detected more frequently among cases (267/3887, 6.9%) than controls (115/4976, 2.3%), among cases with pneumonia chest X-ray findings (8.5%) than without (5.5%), and among controls with respiratory tract illness (3.8%) than without (1.8%; all p ≤ 0.001). HMPV-positive cases were negatively associated with the detection of other viruses (aOR, 0.18), especially RSV (aOR, 0.11; all p < 0.0001), and positively associated with the detection of bacteria (aORs, 1.77; p 0.03). No single clinical syndrome distinguished hMPV-positive from other cases. Among hMPV-positive cases, 65.2% were aged <1 year and 27.5% had pneumonia danger signs; positive predictive value for hMPV aetiology was 74.5%; mortality was 3.9%, similar to RSV-positive (2.4%) and lower than that among other cases (9.6%). AB - HMPV-associated severe paediatric pneumonia in high-burden settings was predominantly in young infants and clinically indistinguishable from RSV. HMPV-positives had low case fatality, similar to that in RSV-positives. AB - Author manuscript AN - cdc:261946 C4 - PMC13076004 DO - https://doi.org/10.1016/j.cmi.2024.10.023 IS - 3 J2 - Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases KW - Pneumonia KW - Female KW - Africa KW - Multiplex Polymerase Chain Reaction KW - Paramyxoviridae Infections KW - Respiratory Syncytial Virus Infections KW - Nasopharynx KW - Severity of Illness Index KW - Metapneumovirus KW - Infant KW - Case-Control Studies KW - Male KW - Pneumonia, Viral KW - Humans KW - Child, Preschool KW - Africa KW - Asia KW - Human metapneumovirus (hMPV) KW - Paediatric KW - Severe pneumonia KW - Humans KW - Metapneumovirus KW - Paramyxoviridae Infections KW - Infant KW - Female KW - Male KW - Child, Preschool KW - Pneumonia, Viral KW - Africa KW - Pneumonia KW - Case-Control Studies KW - Nasopharynx KW - Respiratory Syncytial Virus Infections KW - Severity of Illness Index KW - Multiplex Polymerase Chain Reaction LA - eng PY - 2025 T2 - Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases T2 - Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases, 2025, v. 31, no. 3 TI - Epidemiology of Human Metapneumovirus Among Children With Severe or Very Severe Pneumonia in High Pneumonia Burden Settings: the Pneumonia Etiology Research For Child Health (PERCH) Study Experience. VL - 31 UR - https://stacks.cdc.gov/view/cdc/261946 ER -
Literacy and Language Barriers to Overcome in Laboratory Medicine.

Lazaro, Gerardo ;

Taillepierre, Julio Dicent

December 2024 | Clinics in Laboratory Medicine, 2024, v. 44, no. 4

In the context of laboratory medicine, the authors describe 3 barriers to health communication: access, health communication, and language responsiveness. These barriers are interconnected and present in millions of people in need of equitable access to health communication. Equitable access entails health communication written in plain language an ...

10/10/2026

Supporting Files

Title : Literacy and Language Barriers to Overcome in Laboratory Medicine. Personal Author(s) : Lazaro, Gerardo;Taillepierre, Julio Dicent;Richwine, Chelsea; Published Date : December 2024 Pages in Document : 629-645 (17 pdf pages) Source : Clinics in Laboratory Medicine, 2024, v. 44, no. 4 DOI : https://doi.org/10.1016/j.cll.2024.07.002 Journal Title : Clinics in Laboratory Medicine
Lazaro, G., Taillepierre, J. D., & Richwine, C. (2024). Literacy and Language Barriers to Overcome in Laboratory Medicine. Clinics in Laboratory Medicine, 44(4). https://doi.org/10.1016/j.cll.2024.07.002

Lazaro, Gerardo, Julio Dicent Taillepierre, and Chelsea Richwine. "Literacy and Language Barriers to Overcome in Laboratory Medicine." Clinics in Laboratory Medicine 44, no. 4 (2024). https://doi.org/10.1016/j.cll.2024.07.002.

Lazaro, Gerardo, et al. "Literacy and Language Barriers to Overcome in Laboratory Medicine." Clinics in Laboratory Medicine, vol. 44, no. 4, 2024. Stacks. https://doi.org/10.1016/j.cll.2024.07.002.
Export RIS Citation Information. TY - Journal Article AU - Lazaro, Gerardo AU - Taillepierre, Julio Dicent AU - Richwine, Chelsea AB - In the context of laboratory medicine, the authors describe 3 barriers to health communication: access, health communication, and language responsiveness. These barriers are interconnected and present in millions of people in need of equitable access to health communication. Equitable access entails health communication written in plain language and languages other than English to address language and literacy barriers and increase trust by avoiding language discordance and the spread of infodemics. This review includes several options to implement multidisciplinary efforts that lead to measurable improvements in health literacy. AB - Author manuscript AN - cdc:261945 C4 - PMC11974352 DO - https://doi.org/10.1016/j.cll.2024.07.002 IS - 4 J2 - Clinics in Laboratory Medicine KW - Health Communication KW - Communication Barriers KW - Language KW - Humans KW - Health Services Accessibility KW - Health Literacy KW - Health KW - Literacy KW - Laboratory KW - Medicine KW - Language KW - Access KW - Clinical KW - Equity KW - Humans KW - Communication Barriers KW - Health Literacy KW - Language KW - Health Services Accessibility KW - Health Communication LA - eng PY - 2024 T2 - Clinics in Laboratory Medicine T2 - Clinics in Laboratory Medicine, 2024, v. 44, no. 4 TI - Literacy and Language Barriers to Overcome in Laboratory Medicine. VL - 44 UR - https://stacks.cdc.gov/view/cdc/261945 ER -
A Randomized Crossover Trial of Acceptability of Quadruple-Fortified Salt in Women and Their Households in Southern India.

Guetterman, Heather M. ;

Rajagopalan, Kripa

January 2025 | The Journal of Nutrition, 2025, v. 155, no. 1

Double-fortified salt (DFS; iron, iodine) improved iron status in randomized trials and was incorporated into India's social safety net programs, suggesting opportunities to address other micronutrient deficiencies.To evaluate the acceptability of quadruple-fortified salt (QFS; iron, iodine, folic acid, and vitamin B) in women and their households, ...

10/10/2026

Supporting Files

Title : A Randomized Crossover Trial of Acceptability of Quadruple-Fortified Salt in Women and Their Households in Southern India. Personal Author(s) : Guetterman, Heather M.;Rajagopalan, Kripa;Fox, Allison M.;Johnson, Christina B.;Fothergill, Amy;George, Nisha;Krisher, Jesse T.;Haas, Jere D.;Mehta, Saurabh;Williams, Jennifer L.;Crider, Krista S.;Finkelstein, Julia L.; Published Date : January 2025 Pages in Document : 322-337 (33 pdf pages) Source : The Journal of Nutrition, 2025, v. 155, no. 1 DOI : https://doi.org/10.1016/j.tjnut.2024.10.037 Journal Title : The Journal of Nutrition
Guetterman, H. M., Rajagopalan, K., Fox, A. M., Johnson, C. B., Fothergill, A., George, N., Krisher, J. T., Haas, J. D., Mehta, S., Williams, J. L., Crider, K. S., & Finkelstein, J. L. (2025). A Randomized Crossover Trial of Acceptability of Quadruple-Fortified Salt in Women and Their Households in Southern India. The Journal of Nutrition, 155(1). https://doi.org/10.1016/j.tjnut.2024.10.037

Guetterman, Heather M., Kripa Rajagopalan, Allison M. Fox, Christina B. Johnson, Amy Fothergill, Nisha George, and Jesse T. Krisher, et al.. "A Randomized Crossover Trial of Acceptability of Quadruple-Fortified Salt in Women and Their Households in Southern India." The Journal of Nutrition 155, no. 1 (2025). https://doi.org/10.1016/j.tjnut.2024.10.037.

Guetterman, Heather M., et al. "A Randomized Crossover Trial of Acceptability of Quadruple-Fortified Salt in Women and Their Households in Southern India." The Journal of Nutrition, vol. 155, no. 1, 2025. Stacks. https://doi.org/10.1016/j.tjnut.2024.10.037.
Export RIS Citation Information. TY - Journal Article AU - Guetterman, Heather M. AU - Rajagopalan, Kripa AU - Fox, Allison M. AU - Johnson, Christina B. AU - Fothergill, Amy AU - George, Nisha AU - Krisher, Jesse T. AU - Haas, Jere D. AU - Mehta, Saurabh AU - Williams, Jennifer L. AU - Crider, Krista S. AU - Finkelstein, Julia L. AB - Double-fortified salt (DFS; iron, iodine) improved iron status in randomized trials and was incorporated into India's social safety net programs, suggesting opportunities to address other micronutrient deficiencies. AB - To evaluate the acceptability of quadruple-fortified salt (QFS; iron, iodine, folic acid, and vitamin B AB - ) in women and their households, using a randomized crossover trial design and triangle tests. AB - Women 18-49 y (n = 77) and their households were randomly assigned to receive QFS or DFS in a randomized crossover design over a 3-wk period (week 1: QFS/DFS, week 2: iodized salt, week 3: DFS/QFS). Each week, participants completed a 9-point hedonic questionnaire (1 = dislike extremely to 9 = like extremely) to evaluate 5 sensory domains (color, odor, taste, texture, and overall acceptability) of the intervention, and the remaining salt was weighed using a digital scale. Triangle tests were conducted among women to evaluate sensory discrimination of salt consumed in rice dishes prepared using standardized recipes. Mixed models were used to examine hedonic ratings and salt use; salt type, sequence, and period were included as fixed effects, and household was included as a random effect. Binomial tests were used to evaluate sensory discrimination of salt type in triangle tests. AB - Mean hedonic ratings for most of the 5 sensory domains were ≥7 (like moderately) and did not differ by salt type [overall acceptability mean (SD): QFS: 7.8 (0.7) compared with DFS: 7.7 (1.2); P = 0.68]. Household salt use (weighed) did not differ by salt type. During the 3-wk intervention period, weighed salt use and hedonic ratings significantly increased, indicating a period effect independent of salt type or sequence. In triangle tests, rice samples prepared with QFS, DFS, or iodized salt were not distinguishable. AB - Acceptability of QFS was high, based on individual hedonic ratings and weighed household salt use. Rice dishes prepared with DFS, QFS, and iodized salt were not distinguishable. Findings informed the design of a randomized trial of QFS in this population. This trial was registered at clinicaltrials.gov as NCT03853304 and CTRI/2024/04/066208. AB - Author manuscript AN - cdc:261944 C4 - PMC11795687 DO - https://doi.org/10.1016/j.tjnut.2024.10.037 IS - 1 J2 - The Journal of Nutrition KW - Iodine KW - Adolescent KW - Sodium Chloride, Dietary KW - Female KW - Family Characteristics KW - Vitamin B 12 KW - Young Adult KW - Iron, Dietary KW - Cross-Over Studies KW - Food, Fortified KW - Surveys and Questionnaires KW - Folic Acid KW - Middle Aged KW - Humans KW - Adult KW - Acceptability KW - folic acid KW - vitamin B KW - 12 KW - periconceptional KW - trial KW - fortification KW - India KW - acceptability KW - Humans KW - Female KW - Adult KW - Sodium Chloride, Dietary KW - Cross-Over Studies KW - Food, Fortified KW - Middle Aged KW - Iodine KW - Young Adult KW - Adolescent KW - Family Characteristics KW - Folic Acid KW - Vitamin B 12 KW - Iron, Dietary KW - Surveys and Questionnaires LA - eng PY - 2025 T2 - The Journal of Nutrition T2 - The Journal of Nutrition, 2025, v. 155, no. 1 TI - A Randomized Crossover Trial of Acceptability of Quadruple-Fortified Salt in Women and Their Households in Southern India. VL - 155 UR - https://stacks.cdc.gov/view/cdc/261944 ER -
Patterns and Differences in Lung Cancer Treatment: United States, 2015-2020.

Kava, Christine M. ;

Siegel, David A.

April 2025 | Chest, 2025, v. 167, no. 4

Treatment for lung cancer can improve prognosis, but 5-year survival remains low at 26%. An examination of treatment using data with higher population coverage, and among a broader number of treatment modalities and individual characteristics, would provide greater insight into differences in lung cancer treatment.Among adults diagnosed with lung c ...

10/10/2026

Supporting Files

Title : Patterns and Differences in Lung Cancer Treatment: United States, 2015-2020. Personal Author(s) : Kava, Christine M.;Siegel, David A.;Qin, Jin;Sabatino, Susan A.;Wilson, Reda;Wu, Manxia; Published Date : April 2025 Pages in Document : 1218-1231 (23 pdf pages) Source : Chest, 2025, v. 167, no. 4 DOI : https://doi.org/10.1016/j.chest.2024.10.033 Journal Title : Chest
Kava, C. M., Siegel, D. A., Qin, J., Sabatino, S. A., Wilson, R., & Wu, M. (2025). Patterns and Differences in Lung Cancer Treatment: United States, 2015-2020. Chest, 167(4). https://doi.org/10.1016/j.chest.2024.10.033

Kava, Christine M., David A. Siegel, Jin Qin, Susan A. Sabatino, Reda Wilson, and Manxia Wu. "Patterns and Differences in Lung Cancer Treatment: United States, 2015-2020." Chest 167, no. 4 (2025). https://doi.org/10.1016/j.chest.2024.10.033.

Kava, Christine M., et al. "Patterns and Differences in Lung Cancer Treatment: United States, 2015-2020." Chest, vol. 167, no. 4, 2025. Stacks. https://doi.org/10.1016/j.chest.2024.10.033.
Export RIS Citation Information. TY - Journal Article AU - Kava, Christine M. AU - Siegel, David A. AU - Qin, Jin AU - Sabatino, Susan A. AU - Wilson, Reda AU - Wu, Manxia AB - Treatment for lung cancer can improve prognosis, but 5-year survival remains low at 26%. An examination of treatment using data with higher population coverage, and among a broader number of treatment modalities and individual characteristics, would provide greater insight into differences in lung cancer treatment. AB - Among adults diagnosed with lung cancer, how does reported receipt of lung cancer treatment differ by sociodemographic characteristics? AB - We used 2015-2020 National Program of Cancer Registry data covering 89% of the US population to describe first-course treatment among people aged ≥ 20 years and diagnosed with lung and bronchus cancer. We performed multivariable logistic regression to examine associations between sociodemographic characteristics and treatment received. AB - Among 1,068,155 people diagnosed with lung cancer, 22% received surgery, 41% received chemotherapy, 40% received radiation, 13% received immunotherapy, and 75% received at least one of the four treatments. People who were aged ≥ 45 years (OR range, 0.08-0.67); were of American Indian or Alaska Native (OR, 0.82; 95% CI, 0.77-0.87), Black (OR, 0.82; 95% CI, 0.81-0.84), or Hispanic (OR, 0.80; 95% CI, 0.78-0.82) race/ethnicity; resided in a nonmetropolitan county (OR, 0.98; 0.96-0.99); resided in the bottom 25% (OR, 0.80; 95% CI, 0.78-0.81) and middle 50% (OR, 0.87; 95% CI, 0.86-0.88) of counties by economic status (considers unemployment rate, per capita market income, and poverty rate); and in the West US census region (OR, 0.95; 95% CI, 0.94-0.97) had significantly lower odds of receiving at least 1 of the 4 treatments. AB - Chemotherapy and radiation were the most common types of first-course treatment reported. Receipt of at least one of the four treatments examined was lower among several groups, including certain racial and ethnic groups and those residing in counties with lower economic status. Future studies might further identify and intervene on factors underlying differences. AB - Author manuscript AN - cdc:261943 C4 - PMC11985310 DO - https://doi.org/10.1016/j.chest.2024.10.033 IS - 4 J2 - Chest KW - Lung Neoplasms KW - Female KW - Healthcare Disparities KW - Male KW - Aged KW - Middle Aged KW - Humans KW - Registries KW - Adult KW - disparities KW - drug therapy KW - lung cancer KW - National Program of Cancer Registries KW - therapeutics KW - Humans KW - Lung Neoplasms KW - Male KW - Female KW - Middle Aged KW - Aged KW - Registries KW - Adult KW - Healthcare Disparities LA - eng PY - 2025 T2 - Chest T2 - Chest, 2025, v. 167, no. 4 TI - Patterns and Differences in Lung Cancer Treatment: United States, 2015-2020. VL - 167 UR - https://stacks.cdc.gov/view/cdc/261943 ER -
Predictors of HIV Seroconversion in Botswana.

CUI, Yifan ;

MOYO, Sikhulile

March 2025 | AIDS (London, England), 2025, v. 39, no. 3

To identify predictors of HIV acquisition in Botswana.We applied machine learning approaches to identify HIV risk predictors using existing data from a large, well characterized HIV incidence cohort.We applied machine learning (randomForestSRC) to analyze data from a large population-based HIV incidence cohort enrolled in a cluster-randomized HIV p ...

10/10/2026

Supporting Files

Title : Predictors of HIV Seroconversion in Botswana. Personal Author(s) : CUI, Yifan;MOYO, Sikhulile;PRETORIUS HOLME, Molly;E HURWITZ, Kathleen;CHOGA, Wonderful;BENNETT, Kara;CHAKALISA, Unoda;SAN, James Emmanuel;MANYAKE, Kutlo;KGATHI, Coulson;DIPHOKO, Ame;GASEITSIWE, Simani;GAOLATHE, Tendani;ESSEX, M.;TCHETGEN TCHETGEN, Eric;MAKHEMA, Joseph M.;LOCKMAN, Shahin; Published Date : March 2025 Pages in Document : 290-297 (14 pdf pages) Source : AIDS (London, England), 2025, v. 39, no. 3 DOI : https://doi.org/10.1097/QAD.0000000000004055 Journal Title : AIDS (London, England)
CUI, Y., MOYO, S., PRETORIUS HOLME, M., E HURWITZ, K., CHOGA, W., BENNETT, K., CHAKALISA, U., SAN, J. E., MANYAKE, K., KGATHI, C., DIPHOKO, A., GASEITSIWE, S., GAOLATHE, T., ESSEX, M., TCHETGEN TCHETGEN, E., MAKHEMA, J. M., & LOCKMAN, S. (2025). Predictors of HIV Seroconversion in Botswana. AIDS (London, England), 39(3). https://doi.org/10.1097/QAD.0000000000004055

CUI, Yifan, Sikhulile MOYO, Molly PRETORIUS HOLME, Kathleen E HURWITZ, Wonderful CHOGA, Kara BENNETT, and Unoda CHAKALISA, et al.. "Predictors of HIV Seroconversion in Botswana." AIDS (London, England) 39, no. 3 (2025). https://doi.org/10.1097/QAD.0000000000004055.

CUI, Yifan, et al. "Predictors of HIV Seroconversion in Botswana." AIDS (London, England), vol. 39, no. 3, 2025. Stacks. https://doi.org/10.1097/QAD.0000000000004055.
Export RIS Citation Information. TY - Journal Article AU - CUI, Yifan AU - MOYO, Sikhulile AU - PRETORIUS HOLME, Molly AU - E HURWITZ, Kathleen AU - CHOGA, Wonderful AU - BENNETT, Kara AU - CHAKALISA, Unoda AU - SAN, James Emmanuel AU - MANYAKE, Kutlo AU - KGATHI, Coulson AU - DIPHOKO, Ame AU - GASEITSIWE, Simani AU - GAOLATHE, Tendani AU - ESSEX, M. AU - TCHETGEN TCHETGEN, Eric AU - MAKHEMA, Joseph M. AU - LOCKMAN, Shahin AB - To identify predictors of HIV acquisition in Botswana. AB - We applied machine learning approaches to identify HIV risk predictors using existing data from a large, well characterized HIV incidence cohort. AB - We applied machine learning (randomForestSRC) to analyze data from a large population-based HIV incidence cohort enrolled in a cluster-randomized HIV prevention trial in 30 communities across Botswana. We sought to identify the most important risk factors for HIV acquisition, starting with 110 potential predictors. AB - During a median 29-month follow-up of 8551 HIV-negative adults, 147 (1.7%) acquired HIV. Our machine learning analysis found that for females, the most important variables for predicting HIV acquisition were the use of injectable hormonal contraception, frequency of sex in the prior 3 months with the most recent partner and residing in a community with HIV prevalence of 29% or higher. For the small proportion (0.3%) of females who had all three risk factors, their estimated probability of acquiring HIV during 29 months of follow-up was 34% (approximate annual incidence of 14%). For males, nonlong-term relationships with the most recent partner and community HIV prevalence of 34% or higher were the most important HIV risk predictors. The 6% of males who had both risk factors had a 5.1% probability of acquiring HIV during the follow-up period (approximate annual incidence of 2.1%). AB - Machine learning approaches allowed us to analyze a large number of variables to efficiently identify key factors strongly predictive of HIV risk. These factors could help target HIV prevention interventions in Botswana. AB - NCT01965470. AB - Author manuscript AN - cdc:261942 C4 - PMC11779586 DO - https://doi.org/10.1097/QAD.0000000000004055 IS - 3 J2 - AIDS (London, England) KW - Adolescent KW - Female KW - HIV Seropositivity KW - Young Adult KW - Machine Learning KW - Risk Factors KW - Incidence KW - Seroconversion KW - Male KW - Middle Aged KW - Humans KW - Adult KW - HIV Infections KW - HIV risk factors KW - HIV incidence KW - machine learning KW - Ya Tsie Study KW - BCPP KW - Botswana KW - Africa KW - Adolescent KW - Adult KW - Female KW - Humans KW - Male KW - Middle Aged KW - Young Adult KW - HIV Infections KW - HIV Seropositivity KW - Incidence KW - Machine Learning KW - Risk Factors KW - Seroconversion LA - eng PY - 2025 T2 - AIDS (London, England) T2 - AIDS (London, England), 2025, v. 39, no. 3 TI - Predictors of HIV Seroconversion in Botswana. VL - 39 UR - https://stacks.cdc.gov/view/cdc/261942 ER -
Screening For Adverse Childhood Experiences: a Critical Appraisal.

Austin, Anna E. ;

Anderson, Kayla N.

December 2024 | Pediatrics, 2024, v. 154, no. 6

Adverse childhood experiences (ACEs) are common and can impact health across the life course. Thus, it is essential for professionals in child- and family-serving roles, including pediatric and adult primary care clinicians, to understand the health implications of childhood adversity and trauma and respond appropriately. Screening for ACEs in heal ...

10/10/2026

Supporting Files

Title : Screening For Adverse Childhood Experiences: a Critical Appraisal. Personal Author(s) : Austin, Anna E.;Anderson, Kayla N.;Goodson, Marissa;Niolon, Phyllis Holditch;Swedo, Elizabeth A.;Terranella, Andrew;Bacon, Sarah; Published Date : December 2024 Pages in Document : e2024067307(14 pdf pages) Source : Pediatrics, 2024, v. 154, no. 6 DOI : https://doi.org/10.1542/peds.2024-067307 Journal Title : Pediatrics
Austin, A. E., Anderson, K. N., Goodson, M., Niolon, P. H., Swedo, E. A., Terranella, A., & Bacon, S. (2024). Screening For Adverse Childhood Experiences: a Critical Appraisal. Pediatrics, 154(6). https://doi.org/10.1542/peds.2024-067307

Austin, Anna E., Kayla N. Anderson, Marissa Goodson, Phyllis Holditch Niolon, Elizabeth A. Swedo, Andrew Terranella, and Sarah Bacon. "Screening For Adverse Childhood Experiences: a Critical Appraisal." Pediatrics 154, no. 6 (2024). https://doi.org/10.1542/peds.2024-067307.

Austin, Anna E., et al. "Screening For Adverse Childhood Experiences: a Critical Appraisal." Pediatrics, vol. 154, no. 6, 2024. Stacks. https://doi.org/10.1542/peds.2024-067307.
Export RIS Citation Information. TY - Journal Article AU - Austin, Anna E. AU - Anderson, Kayla N. AU - Goodson, Marissa AU - Niolon, Phyllis Holditch AU - Swedo, Elizabeth A. AU - Terranella, Andrew AU - Bacon, Sarah AB - Adverse childhood experiences (ACEs) are common and can impact health across the life course. Thus, it is essential for professionals in child- and family-serving roles, including pediatric and adult primary care clinicians, to understand the health implications of childhood adversity and trauma and respond appropriately. Screening for ACEs in health care settings has received attention as a potential approach to ACEs identification and response. Careful examination of the existing evidence on ACEs screening and consideration, from a clinical and ethical perspective, of the potential benefits, challenges, and harms is critical to ensuring evidence-informed practice. In this critical appraisal, we synthesize existing systematic and scoping reviews on ACEs screening, summarize recent studies on the ability of ACEs to predict health outcomes at the individual level, and provide a comprehensive overview of potential benefits, challenges, and harms of ACEs screening. We identify gaps in the existing evidence base and specify directions for future research. We also describe trauma-informed, relational care as an orientation and perspective that can help pediatric and primary care clinicians to sensitively assess for and respond to ACEs and other potentially traumatic experiences. Overall, we do not yet have sufficient evidence regarding the potential benefits, challenges, and harms of ACEs screening in health care and other settings. In the absence of this evidence, we cannot assume that screening will not cause harm and that potential benefits outweigh potential harms. AB - Author manuscript AN - cdc:261941 C4 - PMC11891546 DO - https://doi.org/10.1542/peds.2024-067307 IS - 6 J2 - Pediatrics KW - Adverse Childhood Experiences KW - Child KW - Mass Screening KW - Humans KW - Primary Health Care KW - Humans KW - Adverse Childhood Experiences KW - Child KW - Mass Screening KW - Primary Health Care LA - eng PY - 2024 T2 - Pediatrics T2 - Pediatrics, 2024, v. 154, no. 6 TI - Screening For Adverse Childhood Experiences: a Critical Appraisal. VL - 154 UR - https://stacks.cdc.gov/view/cdc/261941 ER -
Fatal Borealpox in an Immunosuppressed Patient Treated With Antivirals and Vaccinia Immunoglobulin-Alaska, 2023.

Rogers, Julia H. ;

Westley, Benjamin

June 4, 2025 | Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 2025, v. 80, no. 5

Borealpox virus (BRPV, formerly known as Alaskapox virus) is a zoonotic member of the Orthopoxvirus genus first identified in a person in 2015. In the 6 patients with infection previously observed, BRPV involved mild and self-limiting illness. We report the first fatal BRPV infection in an immunosuppressed patient.A man aged 69 years from Alaska's ...

10/10/2026

Supporting Files

Title : Fatal Borealpox in an Immunosuppressed Patient Treated With Antivirals and Vaccinia Immunoglobulin-Alaska, 2023. Personal Author(s) : Rogers, Julia H.;Westley, Benjamin;Mego, Thomas;Newell, Katherine G.;Laurance, John;Smith, Lisa;Parker, Jayme;Park, Sarah Y.;Venkatasubrahmanyam, Shivkumar;Noll, Nicholas;Bercovici, Sivan;Rao, Agam K.;McCollum, Andrea M.;Davidson, Whitni;Carson, William C.;Townsend, Michael B.;Doty, Jeffrey B.;Hutson, Christina;Li, Yu;Wilkins, Kimberly;Deng, Jiusheng;Gigante, Crystal M.;Satheshkumar, Panayampalli S.;Tuttle, Alexandra;Villalba, Julian A.;Bhatnagar, Julu;Reagan-Steiner, Sarah;Castrodale, Louisa J.;McLaughlin, Joseph B.; Published Date : June 4, 2025 Pages in Document : 1053-1059 (16 pdf pages) Source : Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 2025, v. 80, no. 5 DOI : https://doi.org/10.1093/cid/ciae536 Journal Title : Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Rogers, J. H., Westley, B., Mego, T., Newell, K. G., Laurance, J., Smith, L., Parker, J., Park, S. Y., Venkatasubrahmanyam, S., Noll, N., Bercovici, S., Rao, A. K., McCollum, A. M., Davidson, W., Carson, W. C., Townsend, M. B., Doty, J. B., Hutson, C., Li, Y., ... McLaughlin, J. B. (2025). Fatal Borealpox in an Immunosuppressed Patient Treated With Antivirals and Vaccinia Immunoglobulin-Alaska, 2023. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 80(5). https://doi.org/10.1093/cid/ciae536

Rogers, Julia H., Benjamin Westley, Thomas Mego, Katherine G. Newell, John Laurance, Lisa Smith, and Jayme Parker, et al.. "Fatal Borealpox in an Immunosuppressed Patient Treated With Antivirals and Vaccinia Immunoglobulin-Alaska, 2023." Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America 80, no. 5 (2025). https://doi.org/10.1093/cid/ciae536.

Rogers, Julia H., et al. "Fatal Borealpox in an Immunosuppressed Patient Treated With Antivirals and Vaccinia Immunoglobulin-Alaska, 2023." Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, vol. 80, no. 5, 2025. Stacks. https://doi.org/10.1093/cid/ciae536.
Export RIS Citation Information. TY - Journal Article AU - Rogers, Julia H. AU - Westley, Benjamin AU - Mego, Thomas AU - Newell, Katherine G. AU - Laurance, John AU - Smith, Lisa AU - Parker, Jayme AU - Park, Sarah Y. AU - Venkatasubrahmanyam, Shivkumar AU - Noll, Nicholas AU - Bercovici, Sivan AU - Rao, Agam K. AU - McCollum, Andrea M. AU - Davidson, Whitni AU - Carson, William C. AU - Townsend, Michael B. AU - Doty, Jeffrey B. AU - Hutson, Christina AU - Li, Yu AU - Wilkins, Kimberly AU - Deng, Jiusheng AU - Gigante, Crystal M. AU - Satheshkumar, Panayampalli S. AU - Tuttle, Alexandra AU - Villalba, Julian A. AU - Bhatnagar, Julu AU - Reagan-Steiner, Sarah AU - Castrodale, Louisa J. AU - McLaughlin, Joseph B. AB - Borealpox virus (BRPV, formerly known as Alaskapox virus) is a zoonotic member of the Orthopoxvirus genus first identified in a person in 2015. In the 6 patients with infection previously observed, BRPV involved mild and self-limiting illness. We report the first fatal BRPV infection in an immunosuppressed patient. AB - A man aged 69 years from Alaska's Kenai Peninsula was receiving anti-CD20 therapy for chronic lymphocytic leukemia. He presented to care for a tender, red papule in his right axilla with increasing induration and pain. The patient failed to respond to multiple prescribed antibiotic regimens and was hospitalized 65 days after symptom onset for progression of presumed infectious cellulitis. BRPV was eventually detected through orthopoxvirus real-time polymerase chain reaction testing of mucosal swabs. He received combination antiviral therapy, including 21 days of intravenous tecovirimat, intravenous vaccinia immunoglobulin, and oral brincidofovir. Serial serology was conducted on specimens obtained posttreatment initiation. AB - The patient's condition initially improved with plaque recession, reduced erythema, and epithelization around the axillary lesion beginning 1 week posttherapy. He later exhibited delayed wound healing, malnutrition, acute renal failure, and respiratory failure. He died 138 days after symptom onset. Serologic testing revealed no evidence the patient generated a humoral immune response. No secondary cases were detected. AB - This report demonstrates that BRPV can cause overwhelming disseminated infection in certain immunocompromised patients. Based on the patient's initial response, early BRPV identification and antiviral therapies might have been beneficial. These therapies, in combination with optimized immune function, should be considered for patients at risk for manifestations of BRPV. AB - Author manuscript AN - cdc:261940 C4 - PMC12974313 DO - https://doi.org/10.1093/cid/ciae536 IS - 5 J2 - Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America KW - Cytosine KW - Antiviral Agents KW - Benzamides KW - Fatal Outcome KW - Isoindoles KW - Phthalimides KW - Aged KW - Orthopoxvirus KW - Organophosphonates KW - Male KW - Humans KW - Immunoglobulins, Intravenous KW - Leukemia, Lymphocytic, Chronic, B-Cell KW - Poxviridae Infections KW - Immunocompromised Host KW - Humans KW - Male KW - Antiviral Agents KW - Aged KW - Immunocompromised Host KW - Fatal Outcome KW - Poxviridae Infections KW - Orthopoxvirus KW - Cytosine KW - Organophosphonates KW - Leukemia, Lymphocytic, Chronic, B-Cell KW - Isoindoles KW - Immunoglobulins, Intravenous KW - Benzamides KW - Phthalimides LA - eng PY - 2025 T2 - Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America T2 - Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America, 2025, v. 80, no. 5 TI - Fatal Borealpox in an Immunosuppressed Patient Treated With Antivirals and Vaccinia Immunoglobulin-Alaska, 2023. VL - 80 UR - https://stacks.cdc.gov/view/cdc/261940 ER -
Next-generation 3d Printed Multipurpose Prevention Intravaginal Ring For Prevention of HIV, HSV-2, and Unintended Pregnancy.

Dahl, Denali K. ;

Srinivasan, Priya

December 2024 | Journal of Controlled Release: Official Journal of the Controlled Release Society, 2024, v. 376

Globally, nearly half of all pregnancies are unintended, ∼1.3 million new human immunodeficiency virus (HIV) infections are reported every year, and more than 500 million people are estimated to have a genital herpes simplex virus (HSV-2) infection. Here we report the first 3D printed multipurpose prevention technology (MPT) intravaginal ring (IVR) ...

10/10/2026

Supporting Files

Title : Next-generation 3d Printed Multipurpose Prevention Intravaginal Ring For Prevention of HIV, HSV-2, and Unintended Pregnancy. Personal Author(s) : Dahl, Denali K.;Srinivasan, Priya;Janusziewicz, Rima;King, Jasmine L.;Shrivastava, Roopali;Zhang, Jining;Little, Dawn;Bachman, Shanon;Kelley, Kristen;Cottrell, Mackenzie L.;Schauer, Amanda P.;Sykes, Craig;Kashuba, Angela D.M.;Smith, James;Benhabbour, S. Rahima; Published Date : December 2024 Pages in Document : 1209-1224 (36 pdf pages) Source : Journal of Controlled Release: Official Journal of the Controlled Release Society, 2024, v. 376 DOI : https://doi.org/10.1016/j.jconrel.2024.10.059 Journal Title : Journal of Controlled Release: Official Journal of the Controlled Release Society
Dahl, D. K., Srinivasan, P., Janusziewicz, R., King, J. L., Shrivastava, R., Zhang, J., Little, D., Bachman, S., Kelley, K., Cottrell, M. L., Schauer, A. P., Sykes, C., Kashuba, A. D., Smith, J., & Benhabbour, S. R. (2024). Next-generation 3d Printed Multipurpose Prevention Intravaginal Ring For Prevention of HIV, HSV-2, and Unintended Pregnancy. Journal of Controlled Release: Official Journal of the Controlled Release Society, 376. https://doi.org/10.1016/j.jconrel.2024.10.059

Dahl, Denali K., Priya Srinivasan, Rima Janusziewicz, Jasmine L. King, Roopali Shrivastava, Jining Zhang, and Dawn Little, et al.. "Next-generation 3d Printed Multipurpose Prevention Intravaginal Ring For Prevention of HIV, HSV-2, and Unintended Pregnancy." Journal of Controlled Release: Official Journal of the Controlled Release Society 376 (2024). https://doi.org/10.1016/j.jconrel.2024.10.059.

Dahl, Denali K., et al. "Next-generation 3d Printed Multipurpose Prevention Intravaginal Ring For Prevention of HIV, HSV-2, and Unintended Pregnancy." Journal of Controlled Release: Official Journal of the Controlled Release Society, vol. 376, 2024. Stacks. https://doi.org/10.1016/j.jconrel.2024.10.059.
Export RIS Citation Information. TY - Journal Article AU - Dahl, Denali K. AU - Srinivasan, Priya AU - Janusziewicz, Rima AU - King, Jasmine L. AU - Shrivastava, Roopali AU - Zhang, Jining AU - Little, Dawn AU - Bachman, Shanon AU - Kelley, Kristen AU - Cottrell, Mackenzie L. AU - Schauer, Amanda P. AU - Sykes, Craig AU - Kashuba, Angela D.M. AU - Smith, James AU - Benhabbour, S. Rahima AB - Globally, nearly half of all pregnancies are unintended, ∼1.3 million new human immunodeficiency virus (HIV) infections are reported every year, and more than 500 million people are estimated to have a genital herpes simplex virus (HSV-2) infection. Here we report the first 3D printed multipurpose prevention technology (MPT) intravaginal ring (IVR) for prevention of HIV, HSV-2, and unintended pregnancy. The IVRs were fabricated using state-of-the-art Continuous Liquid Interface Production (CLIP™) 3D printing technology using a biocompatible silicone-urethane based resin. Anti-HIV drug (Dapivirine, DPV), anti-herpes drug (Pritelivir, PTV) and a contraceptive drug (Levonorgestrel, LNG) were loaded in a macaque size IVR (25 mm outer diameter, OD; 6.0 mm cross-section, CS) allometrically scaled from the human size (54 mm OD; 7.6 mm CS) IVR analogue. All three active pharmaceutical ingredients (APIs) were loaded in the IVR using a single-step drug loading process driven by absorption. DPV, PTV, and LNG elicited zero-order release kinetics in vitro in simulated vaginal fluid (SVF) at pH 4 and pH 8 relevant to human and macaque vaginal pH respectively. CLIP 3D printed MPT IVRs remained stable after 6 months of storage at 4 °C with no change in physical, dimensional, or mechanical properties and no change in drug concentration and absence of drug degradation byproducts. The MPT IVRs elicited sustained release of all three APIs in macaques for 28 days with median plasma concentrations of 138 pg/mL (DPV), 18,700 pg/mL (PTV), and 335 pg/mL (LNG). Safety studies demonstrated that the MPT IVRs were safe and well tolerated in the macaques with no observed change or abnormalities in vaginal pH and no significant changes in any of the 22 mucosal cytokines and chemokines tested including pro-inflammatory (IL-1β, IL-6, IL-8, IFN-γ, TNF-α, IL-17, IL-18) and anti-inflammatory (IL-10, IL-12) cytokines while the MPT IVR was in place or after its removal. Additionally, MPT IVRs elicited no observed alterations in systemic CD4+ and CD8+ T cells during the entire study. Collectively, the proposed MPT IVR has potential to expand preventative choices for young women and girls against unintended pregnancy and two highly prevalent sexually transmitted infections (STIs). AB - Author manuscript AN - cdc:261939 C4 - PMC11866343 DO - https://doi.org/10.1016/j.jconrel.2024.10.059 J2 - Journal of Controlled Release: Official Journal of the Controlled Release Society KW - Pregnancy KW - Antiviral Agents KW - Female KW - Animals KW - Anti-HIV Agents KW - Printing, Three-Dimensional KW - Levonorgestrel KW - Herpesvirus 2, Human KW - Pyrimidines KW - Herpes Genitalis KW - Administration, Intravaginal KW - Humans KW - Macaca KW - Pregnancy, Unplanned KW - Contraceptive Devices, Female KW - HIV Infections KW - Multipurpose prevention KW - Intravaginal rings KW - 3D printing KW - HIV KW - HSV-2 KW - Contraception KW - macaques KW - Female KW - Animals KW - Printing, Three-Dimensional KW - Pregnancy, Unplanned KW - HIV Infections KW - Herpes Genitalis KW - Contraceptive Devices, Female KW - Pregnancy KW - Levonorgestrel KW - Antiviral Agents KW - Administration, Intravaginal KW - Herpesvirus 2, Human KW - Pyrimidines KW - Humans KW - Anti-HIV Agents KW - Macaca LA - eng PY - 2024 T2 - Journal of Controlled Release: Official Journal of the Controlled Release Society T2 - Journal of Controlled Release: Official Journal of the Controlled Release Society, 2024, v. 376 TI - Next-generation 3d Printed Multipurpose Prevention Intravaginal Ring For Prevention of HIV, HSV-2, and Unintended Pregnancy. VL - 376 UR - https://stacks.cdc.gov/view/cdc/261939 ER -
Traceback and Testing of Food Epidemiologically Linked to a Norovirus Outbreak at a Wedding Reception.

Papafragkou, Efstathia ;

Kita-Yarbro, Amanda

January 2025 | Journal of Food Protection, 2025, v. 88, no. 1

We investigated a suspected norovirus outbreak associated with a wedding reception in Wisconsin in May 2015. Fifty-six of 106 (53%) wedding attendees were interviewed, and 23 (41%) reported symptoms consistent with norovirus infection. A retrospective cohort study identified fruit salad as the likely vehicle of infection (risk ratio 3.2, 95% confid ...

10/10/2026

Supporting Files

Title : Traceback and Testing of Food Epidemiologically Linked to a Norovirus Outbreak at a Wedding Reception. Personal Author(s) : Papafragkou, Efstathia;Kita-Yarbro, Amanda;Yang, Zihui;Chhabra, Preeti;Davis, Timothy;Blackmore, James;Ziemer, Courtney;Klos, Rachel;Hall, Aron J.;Vinjé, Jan; Published Date : January 2025 Pages in Document : 100395 (17 pdf pages) Source : Journal of Food Protection, 2025, v. 88, no. 1 DOI : https://doi.org/10.1016/j.jfp.2024.100395 Journal Title : Journal of Food Protection
Papafragkou, E., Kita-Yarbro, A., Yang, Z., Chhabra, P., Davis, T., Blackmore, J., Ziemer, C., Klos, R., Hall, A. J., & Vinjé, J. (2025). Traceback and Testing of Food Epidemiologically Linked to a Norovirus Outbreak at a Wedding Reception. Journal of Food Protection, 88(1). https://doi.org/10.1016/j.jfp.2024.100395

Papafragkou, Efstathia, Amanda Kita-Yarbro, Zihui Yang, Preeti Chhabra, Timothy Davis, James Blackmore, Courtney Ziemer, Rachel Klos, Aron J. Hall, and Jan Vinjé. "Traceback and Testing of Food Epidemiologically Linked to a Norovirus Outbreak at a Wedding Reception." Journal of Food Protection 88, no. 1 (2025). https://doi.org/10.1016/j.jfp.2024.100395.

Papafragkou, Efstathia, et al. "Traceback and Testing of Food Epidemiologically Linked to a Norovirus Outbreak at a Wedding Reception." Journal of Food Protection, vol. 88, no. 1, 2025. Stacks. https://doi.org/10.1016/j.jfp.2024.100395.
Export RIS Citation Information. TY - Journal Article AU - Papafragkou, Efstathia AU - Kita-Yarbro, Amanda AU - Yang, Zihui AU - Chhabra, Preeti AU - Davis, Timothy AU - Blackmore, James AU - Ziemer, Courtney AU - Klos, Rachel AU - Hall, Aron J. AU - Vinjé, Jan AB - We investigated a suspected norovirus outbreak associated with a wedding reception in Wisconsin in May 2015. Fifty-six of 106 (53%) wedding attendees were interviewed, and 23 (41%) reported symptoms consistent with norovirus infection. A retrospective cohort study identified fruit salad as the likely vehicle of infection (risk ratio 3.2, 95% confidence interval 1.1--8.3). Norovirus was detected by real-time reverse transcription polymerase chain reaction (RT-qPCR) in stool specimens collected from four attendees and one food handler and in 12 leftover fruit salad samples from both an opened and a sealed container. Norovirus-positive clinical samples (n = 4) were genotyped as GII.4 Sydney and norovirus-positive fruit salad samples (n = 2) confirmed the presence of GII.4 norovirus by Sanger sequencing with 98% nucleotide (n = 236) similarity in 5' end of ORF2 between fruit salad and clinical specimens. In conclusion, this comprehensive norovirus outbreak investigation combined epidemiologic, virologic, and environmental findings to traceback the contaminated food as the source of the outbreak. AB - Author manuscript AN - cdc:261938 C4 - PMC11844314 DO - https://doi.org/10.1016/j.jfp.2024.100395 IS - 1 J2 - Journal of Food Protection KW - Adolescent KW - Genotype KW - Female KW - Gastroenteritis KW - Young Adult KW - Norovirus KW - Retrospective Studies KW - Food Contamination KW - Feces KW - Food Microbiology KW - Male KW - Middle Aged KW - Disease Outbreaks KW - Humans KW - Caliciviridae Infections KW - Adult KW - Foodborne outbreak KW - Norovirus KW - Outbreak investigation KW - Produce KW - Humans KW - Norovirus KW - Disease Outbreaks KW - Caliciviridae Infections KW - Male KW - Retrospective Studies KW - Female KW - Gastroenteritis KW - Adult KW - Feces KW - Food Contamination KW - Middle Aged KW - Genotype KW - Food Microbiology KW - Adolescent KW - Young Adult LA - eng PY - 2025 T2 - Journal of Food Protection T2 - Journal of Food Protection, 2025, v. 88, no. 1 TI - Traceback and Testing of Food Epidemiologically Linked to a Norovirus Outbreak at a Wedding Reception. VL - 88 UR - https://stacks.cdc.gov/view/cdc/261938 ER -
Examining Childhood and Adulthood Stressors as Risk Factors For Gestational Diabetes Mellitus in Working Pregnant Individuals: a Prospective Cohort Study.

Mendez, Lizette ;

Li, Jian

December 2024 | Preventive Medicine, 2024, v. 189

This study aimed to examine the individual and joint associations of adverse childhood experiences (ACEs) and maternal work and non-work related stressors with the risk of gestational diabetes mellitus (GDM).Working pregnant individuals (n = 1163) from a United States (U.S.) prospective cohort conducted in South Carolina between 2016 and 2021 were ...

10/10/2026

Supporting Files

Title : Examining Childhood and Adulthood Stressors as Risk Factors For Gestational Diabetes Mellitus in Working Pregnant Individuals: a Prospective Cohort Study. Personal Author(s) : Mendez, Lizette;Li, Jian;Hsieh, Cheng-Tzu;Zhang, Lu;Britt, Jessica;Crockett, Amy;Chen, Liwei; Published Date : December 2024 Pages in Document : 108163 (16 pdf pages) Source : Preventive Medicine, 2024, v. 189 DOI : https://doi.org/10.1016/j.ypmed.2024.108163 Journal Title : Preventive Medicine
Mendez, L., Li, J., Hsieh, C. T., Zhang, L., Britt, J., Crockett, A., & Chen, L. (2024). Examining Childhood and Adulthood Stressors as Risk Factors For Gestational Diabetes Mellitus in Working Pregnant Individuals: a Prospective Cohort Study. Preventive Medicine, 189. https://doi.org/10.1016/j.ypmed.2024.108163

Mendez, Lizette, Jian Li, Cheng-Tzu Hsieh, Lu Zhang, Jessica Britt, Amy Crockett, and Liwei Chen. "Examining Childhood and Adulthood Stressors as Risk Factors For Gestational Diabetes Mellitus in Working Pregnant Individuals: a Prospective Cohort Study." Preventive Medicine 189 (2024). https://doi.org/10.1016/j.ypmed.2024.108163.

Mendez, Lizette, et al. "Examining Childhood and Adulthood Stressors as Risk Factors For Gestational Diabetes Mellitus in Working Pregnant Individuals: a Prospective Cohort Study." Preventive Medicine, vol. 189, 2024. Stacks. https://doi.org/10.1016/j.ypmed.2024.108163.
Export RIS Citation Information. TY - Journal Article AU - Mendez, Lizette AU - Li, Jian AU - Hsieh, Cheng-Tzu AU - Zhang, Lu AU - Britt, Jessica AU - Crockett, Amy AU - Chen, Liwei AB - This study aimed to examine the individual and joint associations of adverse childhood experiences (ACEs) and maternal work and non-work related stressors with the risk of gestational diabetes mellitus (GDM). AB - Working pregnant individuals (n = 1163) from a United States (U.S.) prospective cohort conducted in South Carolina between 2016 and 2021 were included in the study. ACEs were assessed at study enrollment before 20 gestational weeks (GW), while maternal stressors were assessed in late pregnancy and GDM diagnosis occurred between 24 and 30 GW. Multivariable logistic regressions were performed to assess associations of ACEs and maternal stressors with GDM. AB - Childhood abuse, an ACE subdomain, was associated with an elevated but statistically insignificant risk of GDM (adjusted OR = 1.47; 95 % CI: 0.85-2.53). Only maternal work stressors were associated with an increased risk of GDM (adjusted OR = 2.11; 95 % CI: 1.17-3.79) and the association became much stronger among those with childhood abuse experiences (adjusted OR = 3.80; 95 % CI:1.68-8.60). AB - Among U.S. working pregnant individuals, having work stressors during pregnancy was associated with an elevated risk of developing GDM, particularly among those who had childhood experience of abuse. AB - Author manuscript AN - cdc:261937 C4 - PMC12909098 DO - https://doi.org/10.1016/j.ypmed.2024.108163 J2 - Preventive Medicine KW - Pregnancy KW - Adverse Childhood Experiences KW - Female KW - Risk Factors KW - Women, Working KW - Diabetes, Gestational KW - Prospective Studies KW - Humans KW - Stress, Psychological KW - Adult KW - Gestational diabetes mellitus KW - Adverse childhood experiences KW - Psychosocial stress KW - Occupational stress KW - Life-course perspective KW - Humans KW - Female KW - Diabetes, Gestational KW - Pregnancy KW - Prospective Studies KW - Risk Factors KW - Adult KW - Adverse Childhood Experiences KW - Stress, Psychological KW - Women, Working LA - eng PY - 2024 T2 - Preventive Medicine T2 - Preventive Medicine, 2024, v. 189 TI - Examining Childhood and Adulthood Stressors as Risk Factors For Gestational Diabetes Mellitus in Working Pregnant Individuals: a Prospective Cohort Study. VL - 189 UR - https://stacks.cdc.gov/view/cdc/261937 ER -
Strategies to Reduce Fall Severity After a Perturbation During Ladder Climbing.

Pliner, Erika M. ;

Beschorner, Kurt E.

November 18, 2025 | IISE Transactions on Occupational Ergonomics and Human Factors, 2025, v. 13, no. 4

OCCUPATIONAL APPLICATIONSFalls from ladders remain a significant cause of injuries in workplaces as well as residential settings. While recent research reveals factors related to fall severity from a ladder, strategies that workers can adopt to minimize fall severity are not well understood. Results from our current study indicated that increased u ...

10/10/2026

Supporting Files

Title : Strategies to Reduce Fall Severity After a Perturbation During Ladder Climbing. Personal Author(s) : Pliner, Erika M.;Beschorner, Kurt E.;Jin Seo, Na; Published Date : November 18, 2025 Pages in Document : 229-237 (17 pdf pages) Source : IISE Transactions on Occupational Ergonomics and Human Factors, 2025, v. 13, no. 4 DOI : https://doi.org/10.1080/24725838.2024.2420722 Journal Title : IISE Transactions on Occupational Ergonomics and Human Factors
Pliner, E. M., Beschorner, K. E., & Jin Seo, N. (2025). Strategies to Reduce Fall Severity After a Perturbation During Ladder Climbing. IISE Transactions on Occupational Ergonomics and Human Factors, 13(4). https://doi.org/10.1080/24725838.2024.2420722

Pliner, Erika M., Kurt E. Beschorner, and Na Jin Seo. "Strategies to Reduce Fall Severity After a Perturbation During Ladder Climbing." IISE Transactions on Occupational Ergonomics and Human Factors 13, no. 4 (2025). https://doi.org/10.1080/24725838.2024.2420722.

Pliner, Erika M., et al. "Strategies to Reduce Fall Severity After a Perturbation During Ladder Climbing." IISE Transactions on Occupational Ergonomics and Human Factors, vol. 13, no. 4, 2025. Stacks. https://doi.org/10.1080/24725838.2024.2420722.
Export RIS Citation Information. TY - Journal Article AU - Pliner, Erika M. AU - Beschorner, Kurt E. AU - Jin Seo, Na AB - OCCUPATIONAL APPLICATIONSFalls from ladders remain a significant cause of injuries in workplaces as well as residential settings. While recent research reveals factors related to fall severity from a ladder, strategies that workers can adopt to minimize fall severity are not well understood. Results from our current study indicated that increased upper limb strength, achieving a higher hand hold, and controlled reestablishment of the foot on the rung have summative benefits to reduce fall severity and increase recovery from a misstep perturbation. Ensuring adequate upper limb strength among workers, and training workers to climb ladders leading with hand placement during ascent and foot placement during descent, can facilitate these beneficial strategies to arrest a ladder fall. AB - Author manuscript AN - cdc:261936 C4 - PMC12056126 DO - https://doi.org/10.1080/24725838.2024.2420722 IS - 4 J2 - IISE Transactions on Occupational Ergonomics and Human Factors KW - Female KW - Young Adult KW - Accidents, Occupational KW - Upper Extremity KW - Hand Strength KW - Stair Climbing KW - Male KW - Muscle Strength KW - Accidental Falls KW - Middle Aged KW - Humans KW - Biomechanical Phenomena KW - Adult KW - ladder fall KW - biomechanics KW - hand KW - upper limb KW - strength KW - foot slip KW - perturbation KW - Humans KW - Accidental Falls KW - Male KW - Adult KW - Stair Climbing KW - Female KW - Accidents, Occupational KW - Muscle Strength KW - Biomechanical Phenomena KW - Hand Strength KW - Young Adult KW - Upper Extremity KW - Middle Aged LA - eng PY - 2025 T2 - IISE Transactions on Occupational Ergonomics and Human Factors T2 - IISE Transactions on Occupational Ergonomics and Human Factors, 2025, v. 13, no. 4 TI - Strategies to Reduce Fall Severity After a Perturbation During Ladder Climbing. VL - 13 UR - https://stacks.cdc.gov/view/cdc/261936 ER -
Gonorrhea and Early Syphilis Treatment Practices Among Community Health Care Providers in Baltimore City, Maryland.

Padiernos, Renee ;

Thornton, Nicole

March 2025 | Sexually Transmitted Diseases, 2025, v. 52, no. 3

Ensuring patients receive appropriate (Centers for Disease Control and Prevention-recommended) and prompt (≤14 days of specimen collection) treatment is critical to decrease gonorrhea and early syphilis (ES) incidence. The objectives were to (1) quantify treatment performance among community health care providers (CHPs), (2) compare CHP treatment p ...

10/10/2026

Supporting Files

Title : Gonorrhea and Early Syphilis Treatment Practices Among Community Health Care Providers in Baltimore City, Maryland. Personal Author(s) : Padiernos, Renee;Thornton, Nicole;Muvva, Ravikiran;Marcell, Arik V;Jennings, Jacky M;Schumacher, Christina M; Published Date : March 2025 Pages in Document : 154-161 (17 pdf pages) Source : Sexually Transmitted Diseases, 2025, v. 52, no. 3 DOI : https://doi.org/10.1097/OLQ.0000000000002098 Journal Title : Sexually Transmitted Diseases
Padiernos, R., Thornton, N., Muvva, R., Marcell, A. V., Jennings, J. M., & Schumacher, C. M. (2025). Gonorrhea and Early Syphilis Treatment Practices Among Community Health Care Providers in Baltimore City, Maryland. Sexually Transmitted Diseases, 52(3). https://doi.org/10.1097/OLQ.0000000000002098

Padiernos, Renee, Nicole Thornton, Ravikiran Muvva, Arik V Marcell, Jacky M Jennings, and Christina M Schumacher. "Gonorrhea and Early Syphilis Treatment Practices Among Community Health Care Providers in Baltimore City, Maryland." Sexually Transmitted Diseases 52, no. 3 (2025). https://doi.org/10.1097/OLQ.0000000000002098.

Padiernos, Renee, et al. "Gonorrhea and Early Syphilis Treatment Practices Among Community Health Care Providers in Baltimore City, Maryland." Sexually Transmitted Diseases, vol. 52, no. 3, 2025. Stacks. https://doi.org/10.1097/OLQ.0000000000002098.
Export RIS Citation Information. TY - Journal Article AU - Padiernos, Renee AU - Thornton, Nicole AU - Muvva, Ravikiran AU - Marcell, Arik V AU - Jennings, Jacky M AU - Schumacher, Christina M AB - Ensuring patients receive appropriate (Centers for Disease Control and Prevention-recommended) and prompt (≤14 days of specimen collection) treatment is critical to decrease gonorrhea and early syphilis (ES) incidence. The objectives were to (1) quantify treatment performance among community health care providers (CHPs), (2) compare CHP treatment performance to local health department goals, and (3) describe variation in treatment performance by CHP characteristics in Baltimore City, Maryland. AB - Surveillance data for gonorrhea and ES diagnoses reported between January 2018 and December 2019 were used. Treatment performance measures were calculated for each CHP (gonorrhea: 171 CHPs; ES: 122 CHPs). Measures were (1) percent treated among all diagnoses (goal: ≥90%), (2) percent appropriately treated among diagnoses treated (goal: ≥90% gonorrhea, ≥95% ES), and (3) percent promptly treated among diagnoses appropriately treated (goal: ≥85%). Treatment performance measures and achievement of goals were compared across CHP characteristics. AB - For gonorrhea, median percent treated, appropriately treated, and promptly treated were 71.4%, 95.0%, and 100.0%, respectively; 29.8% met treated goals. The majority achieved appropriately treated (62.9%) and promptly treated (76.8%) goals. Community health care practices reporting high (vs. low) volume of gonorrhea diagnoses less frequently achieved percent-treated goals (12.2% vs. 35.4%, P = 0.008). Median value for all ES treatment performance measures was 100.0%. Most achieved treated (90.2%) and appropriately treated (95.9%) goals. Less than half (49.2%) achieved the promptly treated goal. Community health care practices reporting high (vs. low) volumes of ES less frequently achieved promptly treated goals (33.3% vs. 54.4%, P = 0.045). AB - Substantial gaps in reporting gonorrhea treatment and prompt ES treatment were observed. Practice-level interventions to facilitate reporting gonorrhea treatment and provide prompt ES treatment are needed. AB - Author manuscript AN - cdc:261935 C4 - PMC11794021 DO - https://doi.org/10.1097/OLQ.0000000000002098 IS - 3 J2 - Sexually Transmitted Diseases KW - Syphilis KW - Female KW - Gonorrhea KW - Community Health Workers KW - Male KW - Humans KW - Anti-Bacterial Agents KW - Practice Patterns, Physicians' KW - Adult KW - gonorrhea KW - syphilis KW - treatment performance KW - Humans KW - Gonorrhea KW - Syphilis KW - Male KW - Female KW - Community Health Workers KW - Anti-Bacterial Agents KW - Adult KW - Practice Patterns, Physicians' LA - eng PY - 2025 T2 - Sexually Transmitted Diseases T2 - Sexually Transmitted Diseases, 2025, v. 52, no. 3 TI - Gonorrhea and Early Syphilis Treatment Practices Among Community Health Care Providers in Baltimore City, Maryland. VL - 52 UR - https://stacks.cdc.gov/view/cdc/261935 ER -
The Private Well Water Climate Impact Index: Characterization of Community-level Climate-related Hazards and Vulnerability in the Continental United States.

Peer, Komal ;

Hubbard, Brian

December 2024 | The Science of the Total Environment, 2024, v. 957

Private wells use groundwater as their source and their drinking water quality is unregulated in the United States at the federal level. Due to the lack of water quality regulations, those reliant on private wells have the responsibility of ensuring that the water is safe to drink. Where extreme weather is projected to increase with climate change, ...

10/09/2026

Supporting Files

Title : The Private Well Water Climate Impact Index: Characterization of Community-level Climate-related Hazards and Vulnerability in the Continental United States. Personal Author(s) : Peer, Komal;Hubbard, Brian;Monti, Michele;Vander Kelen, Patrick;Werner, Angela K.; Published Date : December 2024 Pages in Document : 177409 (29 pdf pages) Source : The Science of the Total Environment, 2024, v. 957 DOI : https://doi.org/10.1016/j.scitotenv.2024.177409 Journal Title : The Science of the Total Environment
Peer, K., Hubbard, B., Monti, M., Vander Kelen, P., & Werner, A. K. (2024). The Private Well Water Climate Impact Index: Characterization of Community-level Climate-related Hazards and Vulnerability in the Continental United States. The Science of the Total Environment, 957. https://doi.org/10.1016/j.scitotenv.2024.177409

Peer, Komal, Brian Hubbard, Michele Monti, Patrick Vander Kelen, and Angela K. Werner. "The Private Well Water Climate Impact Index: Characterization of Community-level Climate-related Hazards and Vulnerability in the Continental United States." The Science of the Total Environment 957 (2024). https://doi.org/10.1016/j.scitotenv.2024.177409.

Peer, Komal, et al. "The Private Well Water Climate Impact Index: Characterization of Community-level Climate-related Hazards and Vulnerability in the Continental United States." The Science of the Total Environment, vol. 957, 2024. Stacks. https://doi.org/10.1016/j.scitotenv.2024.177409.
Export RIS Citation Information. TY - Journal Article AU - Peer, Komal AU - Hubbard, Brian AU - Monti, Michele AU - Vander Kelen, Patrick AU - Werner, Angela K. AB - Private wells use groundwater as their source and their drinking water quality is unregulated in the United States at the federal level. Due to the lack of water quality regulations, those reliant on private wells have the responsibility of ensuring that the water is safe to drink. Where extreme weather is projected to increase with climate change, contamination due to climate-related hazards adds further layers of complexity for those relying on private wells. We sought to characterize community-level climate-related hazards and vulnerability for persons dependent on private wells in the continental United States (CONUS). Additional objectives of this work were to quantify the burden to private well water communities by climate region and demographic group. AB - Grounded in the latest climate change framework and private well water literature, we created the Private Well Water Climate Impact Index (PWWCII). We searched the literature and identified nationally consistent, publicly available, sub-county data to build Overall, Drought, Flood, and Wildfire PWWCIIs at the national and state scales. We adapted the technical construction of this relative index from the California Communities Environmental Health Screening Tool (CalEnviroScreen 4.0). AB - The distribution of climate-related impact census tracts varied across CONUS by nationally-normed PWWCII type. Compared to the Southeast where the majority of the 2010 estimated U.S. private well water population lived, the estimated persons dependent upon private well water living in the West had an increased odds of living in higher impact census tracts for the Overall, Drought, and Wildfire PWWCIIs across CONUS. Compared to non-Hispanic White persons, non-Hispanic American Indian and Alaska Native (AI/AN) persons had an increased odds of living in higher impact census tracts for all four PWWCII types across CONUS. AB - The PWWCII fills a gap as it provides a baseline understanding of potential climate-related impacts to communities reliant on private well water across CONUS. AB - Author manuscript AN - cdc:261934 C4 - PMC11988540 DO - https://doi.org/10.1016/j.scitotenv.2024.177409 J2 - The Science of the Total Environment KW - Drinking Water KW - Climate Change KW - Wildfires KW - Droughts KW - Water Quality KW - Water Supply KW - Humans KW - Floods KW - Water Wells KW - Tracking KW - Drinking water KW - Water Wells KW - Spatial analysis KW - Public health surveillance KW - Climate change KW - Climate Change KW - Water Wells KW - Drinking Water KW - Water Supply KW - Water Quality KW - Humans KW - Droughts KW - Floods KW - Wildfires LA - eng PY - 2024 T2 - The Science of the Total Environment T2 - The Science of the Total Environment, 2024, v. 957 TI - The Private Well Water Climate Impact Index: Characterization of Community-level Climate-related Hazards and Vulnerability in the Continental United States. VL - 957 UR - https://stacks.cdc.gov/view/cdc/261934 ER -
Comparative Specialization of Intrinsic Cardiac Neurons in Humans, Mice and Pigs.

Tompkins, John D. ;

Hoover, Donald B.

March 2025 | The Journal of Physiology, 2025, v. 603, no. 7

Intrinsic cardiac neurons (ICNs) play a crucial role in the proper functioning of the heart; yet a paucity of data pertaining to human ICNs exist. We took a multidisciplinary approach to complete a detailed cellular comparison of the structure and function of ICNs from mice, pigs and humans. Immunohistochemistry of whole and sectioned ganglia, tran ...

10/09/2026

Supporting Files

Title : Comparative Specialization of Intrinsic Cardiac Neurons in Humans, Mice and Pigs. Personal Author(s) : Tompkins, John D.;Hoover, Donald B.;Havton, Leif A.;Patel, Janaki C.;Cho, Youngjin;Smith, Elizabeth H.;Biscola, Natalia P.;Ajijola, Olujimi A.;Shivkumar, Kalyanam;Ardell, Jeffrey L.; Published Date : March 2025 Pages in Document : 2043-2070 (44 pdf pages) Source : The Journal of Physiology, 2025, v. 603, no. 7 DOI : https://doi.org/10.1113/JP286714 Journal Title : The Journal of Physiology
Tompkins, J. D., Hoover, D. B., Havton, L. A., Patel, J. C., Cho, Y., Smith, E. H., Biscola, N. P., Ajijola, O. A., Shivkumar, K., & Ardell, J. L. (2025). Comparative Specialization of Intrinsic Cardiac Neurons in Humans, Mice and Pigs. The Journal of Physiology, 603(7). https://doi.org/10.1113/JP286714

Tompkins, John D., Donald B. Hoover, Leif A. Havton, Janaki C. Patel, Youngjin Cho, Elizabeth H. Smith, Natalia P. Biscola, Olujimi A. Ajijola, Kalyanam Shivkumar, and Jeffrey L. Ardell. "Comparative Specialization of Intrinsic Cardiac Neurons in Humans, Mice and Pigs." The Journal of Physiology 603, no. 7 (2025). https://doi.org/10.1113/JP286714.

Tompkins, John D., et al. "Comparative Specialization of Intrinsic Cardiac Neurons in Humans, Mice and Pigs." The Journal of Physiology, vol. 603, no. 7, 2025. Stacks. https://doi.org/10.1113/JP286714.
Export RIS Citation Information. TY - Journal Article AU - Tompkins, John D. AU - Hoover, Donald B. AU - Havton, Leif A. AU - Patel, Janaki C. AU - Cho, Youngjin AU - Smith, Elizabeth H. AU - Biscola, Natalia P. AU - Ajijola, Olujimi A. AU - Shivkumar, Kalyanam AU - Ardell, Jeffrey L. AB - Intrinsic cardiac neurons (ICNs) play a crucial role in the proper functioning of the heart; yet a paucity of data pertaining to human ICNs exist. We took a multidisciplinary approach to complete a detailed cellular comparison of the structure and function of ICNs from mice, pigs and humans. Immunohistochemistry of whole and sectioned ganglia, transmission electron microscopy, intracellular microelectrode recording and dye filling for quantitative morphometry were used to define the neurophysiology, histochemistry and ultrastructure of these neurons across species. The densely packed, smaller ICNs of mouse lacked dendrites, formed axosomatic connections and had high synaptic efficacy constituting an obligatory synapse. At pig ICNs, a convergence of subthreshold cholinergic inputs onto extensive dendritic arbors supported greater summation and integration of synaptic input. Human ICNs were tonically firing, with synaptic stimulation evoking large suprathreshold EPSPs like mouse, and subthreshold potentials like pig. Ultrastructural examination of synaptic terminals revealed conserved architecture, yet small clear vesicles were larger in pigs and humans. The presence and localization of ganglionic neuropeptides was distinct, with abundant vasoactive intestinal polypeptide observed in human but not pig or mouse ganglia, and little substance P or calcitonin gene-related peptide in pig ganglia. Action potential waveforms were similar, but human ICNs had larger after-hyperpolarizations. Intrinsic excitability differed; 95% of human neurons were tonic, all pig neurons were phasic, and both phasic and tonic phenotypes were observed in mouse. In combination, this publicly accessible, multimodal atlas of ICNs from mice, pigs and humans identifies similarities and differences in the evolution of ICNs. KEY POINTS: Intrinsic cardiac neurons (ICNs) are essential to the regulation of cardiac function. We investigated the neurochemistry, morphology, ultrastructure, membrane physiology and synaptic transmission of ICNs from donated human hearts in parallel with identical studies of ICNs from mice and pigs to create a publicly accessible cellular atlas detailing the structure and function of these neurons across species. In addition to presenting foundational data on human ICNs, this comparative study identifies both conserved and derived attributes of these neurons within mammals. The findings have significant implications for understanding the regulation of cardiac autonomic function in humans and may greatly influence strategies for neuromodulation in conditions such as atrial fibrillation and heart failure. AB - Author manuscript AN - cdc:261933 C4 - PMC11957936 DO - https://doi.org/10.1113/JP286714 IS - 7 J2 - The Journal of Physiology KW - Female KW - Swine KW - Animals KW - Neurons KW - Mice, Inbred C57BL KW - Heart KW - Male KW - Humans KW - Middle Aged KW - Adult KW - Action Potentials KW - Mice KW - cardiac physiology KW - autonomic ganglia KW - neurophysiology KW - neurocardiology KW - neuromodulation KW - intracardiac neuron KW - ganglionic neurotransmission KW - homo sapiens KW - Animals KW - Humans KW - Mice KW - Swine KW - Neurons KW - Male KW - Heart KW - Female KW - Mice, Inbred C57BL KW - Action Potentials KW - Middle Aged KW - Adult LA - eng PY - 2025 T2 - The Journal of Physiology T2 - The Journal of Physiology, 2025, v. 603, no. 7 TI - Comparative Specialization of Intrinsic Cardiac Neurons in Humans, Mice and Pigs. VL - 603 UR - https://stacks.cdc.gov/view/cdc/261933 ER -
Assessment and Mitigation of Bias in Influenza and COVID-19 Vaccine Effectiveness Analyses - IVY Network, September 1, 2022-March 30, 2023.

Lewis, Nathaniel M. ;

Harker, Elizabeth J.

January 2025 | Vaccine, 2025, v. 43, no. 2

In test-negative studies of vaccine effectiveness (VE), including patients with co-circulating, vaccine-preventable, respiratory pathogens in the control group for the pathogen of interest can introduce a downward bias on VE estimates.A multicenter sentinel surveillance network in the US prospectively enrolled adults hospitalized with acute respira ...

10/09/2026

Supporting Files

Title : Assessment and Mitigation of Bias in Influenza and COVID-19 Vaccine Effectiveness Analyses - IVY Network, September 1, 2022-March 30, 2023. Personal Author(s) : Lewis, Nathaniel M.;Harker, Elizabeth J.;Leis, Aleda;Zhu, Yuwei;Talbot, H. Keipp;Grijalva, Carlos G.;Halasa, Natasha;Chappell, James D.;Johnson, Cassandra A.;Rice, Todd W.;Casey, Jonathan D.;Lauring, Adam S.;Gaglani, Manjusha;Ghamande, Shekhar;Columbus, Cristie;Steingrub, Jay S.;Shapiro, Nathan I.;Duggal, Abhijit;Felzer, Jamie;Prekker, Matthew E.;Peltan, Ithan D.;Brown, Samuel M.;Hager, David N.;Gong, Michelle N.;Mohamed, Amira;Exline, Matthew C.;Khan, Akram;Wilson, Jennifer G.;Mosier, Jarrod;Qadir, Nida;Chang, Steven Y.;Ginde, Adit A.;Mohr, Nicholas M.;Mallow, Christopher;Harris, Estelle S.;Johnson, Nicholas J.;Srinivasan, Vasisht;Gibbs, Kevin W.;Kwon, Jennie H.;Vaughn, Ivana A.;Ramesh, Mayur;Safdar, Basmah;DeCuir, Jennifer;Surie, Diya;Dawood, Fatimah S.;Ellington, Sascha;Self, Wesley H.;Martin, Emily T.; Published Date : January 2025 Pages in Document : 126492 (19 pdf pages) Source : Vaccine, 2025, v. 43, no. 2 DOI : https://doi.org/10.1016/j.vaccine.2024.126492 Journal Title : Vaccine
Lewis, N. M., Harker, E. J., Leis, A., Zhu, Y., Talbot, H. K., Grijalva, C. G., Halasa, N., Chappell, J. D., Johnson, C. A., Rice, T. W., Casey, J. D., Lauring, A. S., Gaglani, M., Ghamande, S., Columbus, C., Steingrub, J. S., Shapiro, N. I., Duggal, A., Felzer, J., ... Martin, E. T. (2025). Assessment and Mitigation of Bias in Influenza and COVID-19 Vaccine Effectiveness Analyses - IVY Network, September 1, 2022-March 30, 2023. Vaccine, 43(2). https://doi.org/10.1016/j.vaccine.2024.126492

Lewis, Nathaniel M., Elizabeth J. Harker, Aleda Leis, Yuwei Zhu, H. Keipp Talbot, Carlos G. Grijalva, and Natasha Halasa, et al.. "Assessment and Mitigation of Bias in Influenza and COVID-19 Vaccine Effectiveness Analyses - IVY Network, September 1, 2022-March 30, 2023." Vaccine 43, no. 2 (2025). https://doi.org/10.1016/j.vaccine.2024.126492.

Lewis, Nathaniel M., et al. "Assessment and Mitigation of Bias in Influenza and COVID-19 Vaccine Effectiveness Analyses - IVY Network, September 1, 2022-March 30, 2023." Vaccine, vol. 43, no. 2, 2025. Stacks. https://doi.org/10.1016/j.vaccine.2024.126492.
Export RIS Citation Information. TY - Journal Article AU - Lewis, Nathaniel M. AU - Harker, Elizabeth J. AU - Leis, Aleda AU - Zhu, Yuwei AU - Talbot, H. Keipp AU - Grijalva, Carlos G. AU - Halasa, Natasha AU - Chappell, James D. AU - Johnson, Cassandra A. AU - Rice, Todd W. AU - Casey, Jonathan D. AU - Lauring, Adam S. AU - Gaglani, Manjusha AU - Ghamande, Shekhar AU - Columbus, Cristie AU - Steingrub, Jay S. AU - Shapiro, Nathan I. AU - Duggal, Abhijit AU - Felzer, Jamie AU - Prekker, Matthew E. AU - Peltan, Ithan D. AU - Brown, Samuel M. AU - Hager, David N. AU - Gong, Michelle N. AU - Mohamed, Amira AU - Exline, Matthew C. AU - Khan, Akram AU - Wilson, Jennifer G. AU - Mosier, Jarrod AU - Qadir, Nida AU - Chang, Steven Y. AU - Ginde, Adit A. AU - Mohr, Nicholas M. AU - Mallow, Christopher AU - Harris, Estelle S. AU - Johnson, Nicholas J. AU - Srinivasan, Vasisht AU - Gibbs, Kevin W. AU - Kwon, Jennie H. AU - Vaughn, Ivana A. AU - Ramesh, Mayur AU - Safdar, Basmah AU - DeCuir, Jennifer AU - Surie, Diya AU - Dawood, Fatimah S. AU - Ellington, Sascha AU - Self, Wesley H. AU - Martin, Emily T. AB - In test-negative studies of vaccine effectiveness (VE), including patients with co-circulating, vaccine-preventable, respiratory pathogens in the control group for the pathogen of interest can introduce a downward bias on VE estimates. AB - A multicenter sentinel surveillance network in the US prospectively enrolled adults hospitalized with acute respiratory illness from September 1, 2022-March 31, 2023. We evaluated bias in estimates of VE against influenza-associated and COVID-19-associated hospitalization based on: inclusion vs exclusion of patients with a co-circulating virus among VE controls; observance of VE against the co-circulating virus (rather than the virus of interest), unadjusted and adjusted for vaccination against the virus of interest; and observance of influenza or COVID-19 against a sham outcome of respiratory syncytial virus (RSV). AB - Overall VE against influenza-associated hospitalizations was 6 percentage points lower when patients with COVID-19 were included in the control group, and overall VE against COVID-19-associated hospitalizations was 2 percentage points lower when patients with influenza were included in the control group. Analyses of VE against the co-circulating virus and against the sham outcome of RSV showed that downward bias was largely attributable the correlation of vaccination status across pathogens, but also potentially attributable to other sources of residual confounding in VE models. AB - Excluding cases of confounding respiratory pathogens from the control group in VE analysis for a pathogen of interest can reduce downward bias. This real-world analysis demonstrates that such exclusion is a helpful bias mitigation strategy, especially for measuring influenza VE, which included a high proportion of COVID-19 cases among controls. AB - Author manuscript AN - cdc:261932 C4 - PMC12229715 DO - https://doi.org/10.1016/j.vaccine.2024.126492 IS - 2 J2 - Vaccine KW - Female KW - Vaccination KW - SARS-CoV-2 KW - Prospective Studies KW - Aged KW - COVID-19 KW - Young Adult KW - Sentinel Surveillance KW - Influenza Vaccines KW - Bias KW - COVID-19 Vaccines KW - Vaccine Efficacy KW - Hospitalization KW - Male KW - Middle Aged KW - Humans KW - Adult KW - Influenza, Human KW - vaccine effectiveness KW - influenza KW - COVID-19 KW - RSV KW - bias KW - estimation KW - Humans KW - COVID-19 KW - Influenza Vaccines KW - Influenza, Human KW - COVID-19 Vaccines KW - Middle Aged KW - Female KW - Male KW - Vaccine Efficacy KW - Hospitalization KW - Adult KW - Aged KW - Bias KW - SARS-CoV-2 KW - Sentinel Surveillance KW - Prospective Studies KW - Vaccination KW - Young Adult LA - eng PY - 2025 T2 - Vaccine T2 - Vaccine, 2025, v. 43, no. 2 TI - Assessment and Mitigation of Bias in Influenza and COVID-19 Vaccine Effectiveness Analyses - IVY Network, September 1, 2022-March 30, 2023. VL - 43 UR - https://stacks.cdc.gov/view/cdc/261932 ER -
Nurse Perceptions of Barriers to Infection Prevention and Control in Labor and Delivery.

Anderson, Laura E. ;

White, Katelyn A.

March 2025 | Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN, 2025, v. 54, no. 2

To identify nurse perceptions of barriers to performing recommended infection prevention and control practices in labor and delivery to inform future resources tailored to this setting.Qualitative focus groups.The 2023 annual convention of the Association of Women's Health, Obstetric and Neonatal Nurses, New Orleans, LA.A convenience sample of 16 l ...

10/09/2026

Supporting Files

Title : Nurse Perceptions of Barriers to Infection Prevention and Control in Labor and Delivery. Personal Author(s) : Anderson, Laura E.;White, Katelyn A.;Cochran, Ronda L.;Perkins, Kiran M.; Published Date : March 2025 Pages in Document : 210-218 (13 pdf pages) Source : Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN, 2025, v. 54, no. 2 DOI : https://doi.org/10.1016/j.jogn.2024.10.001 Journal Title : Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
Anderson, L. E., White, K. A., Cochran, R. L., & Perkins, K. M. (2025). Nurse Perceptions of Barriers to Infection Prevention and Control in Labor and Delivery. Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN, 54(2). https://doi.org/10.1016/j.jogn.2024.10.001

Anderson, Laura E., Katelyn A. White, Ronda L. Cochran, and Kiran M. Perkins. "Nurse Perceptions of Barriers to Infection Prevention and Control in Labor and Delivery." Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN 54, no. 2 (2025). https://doi.org/10.1016/j.jogn.2024.10.001.

Anderson, Laura E., et al. "Nurse Perceptions of Barriers to Infection Prevention and Control in Labor and Delivery." Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN, vol. 54, no. 2, 2025. Stacks. https://doi.org/10.1016/j.jogn.2024.10.001.
Export RIS Citation Information. TY - Journal Article AU - Anderson, Laura E. AU - White, Katelyn A. AU - Cochran, Ronda L. AU - Perkins, Kiran M. AB - To identify nurse perceptions of barriers to performing recommended infection prevention and control practices in labor and delivery to inform future resources tailored to this setting. AB - Qualitative focus groups. AB - The 2023 annual convention of the Association of Women's Health, Obstetric and Neonatal Nurses, New Orleans, LA. AB - A convenience sample of 16 labor and delivery nurses. AB - Staff of the Centers for Disease Control and Prevention conducted two focus groups using a standardized script. Coding was performed by three reviewers using Krueger's systematic analysis process. AB - Among the 16 participants, 94% were registered nurses, and 6% were advanced practice registered nurses. From our analysis of the data, five major themes emerged, including the following: Lack of Individual and Organizational Accountability in Implementing Recommended Infection Prevention and Control Practices; Inconsistent Application of Guidance Across State, Hospital, and Specialty; The Unpredictable Nature of the Labor and Delivery Setting; Labor and Delivery Is Not Prioritized in the Hospital for Infection Prevention and Control Resources; and Lack of Coordination Across Stages of Care From Prenatal to Postpartum. AB - We identified barriers experienced by nurses to consistently implementing infection prevention and control practices in the labor and delivery setting. These barriers can be addressed through targeted interventions and the development of obstetric-specific infection prevention and control resources. AB - Author manuscript AN - cdc:261931 C4 - PMC11908931 DO - https://doi.org/10.1016/j.jogn.2024.10.001 IS - 2 J2 - Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN KW - Attitude of Health Personnel KW - Pregnancy KW - Obstetric Nursing KW - Focus Groups KW - Infection Control KW - Female KW - Labor, Obstetric KW - Qualitative Research KW - Humans KW - Delivery, Obstetric KW - Adult KW - hospital obstetrics and gynecology department KW - infection control KW - public health KW - obstetric nursing KW - perinatal nursing KW - qualitative KW - quality improvement KW - Humans KW - Female KW - Pregnancy KW - Infection Control KW - Focus Groups KW - Adult KW - Delivery, Obstetric KW - Obstetric Nursing KW - Labor, Obstetric KW - Attitude of Health Personnel KW - Qualitative Research LA - eng PY - 2025 T2 - Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN T2 - Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN, 2025, v. 54, no. 2 TI - Nurse Perceptions of Barriers to Infection Prevention and Control in Labor and Delivery. VL - 54 UR - https://stacks.cdc.gov/view/cdc/261931 ER -
Exposure to Per- and Polyfluoroalkyl Substances (PFAS) in North Carolina Homes: Results From the Indoor PFAS Assessment (IPA) Campaign.

Chang, Naomi Y. ;

Eichler, Clara M.A.

Jun-18-2025 | Environmental Science. Processes & Impacts, Jun-18-2025, v. 27, no. 6

Per and polyfluoroalkyl substances (PFAS) are ubiquitous in the indoor environment, resulting in indoor exposure. However, a dearth of concurrent indoor multi-compartment PFAS measurements, including air, has limited our understanding of the contributions of each exposure pathway to residential PFAS exposure. As part of the Indoor PFAS Assessment ( ...

10/09/2026

Supporting Files

Title : Exposure to Per- and Polyfluoroalkyl Substances (PFAS) in North Carolina Homes: Results From the Indoor PFAS Assessment (IPA) Campaign. Personal Author(s) : Chang, Naomi Y.;Eichler, Clara M.A.;Hubal, Elaine A. Cohen;Surratt, Jason D.;Morrison, Glenn C.;Turpin, Barbara J.; Published Date : Jun-18-2025 Pages in Document : 1654-1670 (31 pdf pages) Source : Environmental Science. Processes & Impacts, Jun-18-2025, v. 27, no. 6 DOI : https://doi.org/10.1039/d4em00525b Journal Title : Environmental Science. Processes & Impacts
Chang, N. Y., Eichler, C. M., Hubal, E. A. C., Surratt, J. D., Morrison, G. C., & Turpin, B. J. (2025). Exposure to Per- and Polyfluoroalkyl Substances (PFAS) in North Carolina Homes: Results From the Indoor PFAS Assessment (IPA) Campaign. Environmental Science. Processes & Impacts, 27(6). https://doi.org/10.1039/d4em00525b

Chang, Naomi Y., Clara M.A. Eichler, Elaine A. Cohen Hubal, Jason D. Surratt, Glenn C. Morrison, and Barbara J. Turpin. "Exposure to Per- and Polyfluoroalkyl Substances (PFAS) in North Carolina Homes: Results From the Indoor PFAS Assessment (IPA) Campaign." Environmental Science. Processes & Impacts 27, no. 6 (2025). https://doi.org/10.1039/d4em00525b.

Chang, Naomi Y., et al. "Exposure to Per- and Polyfluoroalkyl Substances (PFAS) in North Carolina Homes: Results From the Indoor PFAS Assessment (IPA) Campaign." Environmental Science. Processes & Impacts, vol. 27, no. 6, 2025. Stacks. https://doi.org/10.1039/d4em00525b.
Export RIS Citation Information. TY - Journal Article AU - Chang, Naomi Y. AU - Eichler, Clara M.A. AU - Hubal, Elaine A. Cohen AU - Surratt, Jason D. AU - Morrison, Glenn C. AU - Turpin, Barbara J. AB - Per and polyfluoroalkyl substances (PFAS) are ubiquitous in the indoor environment, resulting in indoor exposure. However, a dearth of concurrent indoor multi-compartment PFAS measurements, including air, has limited our understanding of the contributions of each exposure pathway to residential PFAS exposure. As part of the Indoor PFAS Assessment (IPA) Campaign, we measured 35 neutral and ionic PFAS in air, settled dust, drinking water, clothing, and on surfaces in 11 North Carolina homes. Ionic and neutral PFAS measurements reported previously and ionic PFAS measurements reported herein for drinking water (1.4-34.1 ng L AB - ), dust (202-1036 ng g AB - ), and surfaces (4.1 × 10 AB - -1.7 × 10 AB - ng cm AB - ) were used to conduct a residential indoor PFAS exposure assessment. We considered inhalation of air, ingestion of drinking water and dust, mouthing of clothing (children only), and transdermal uptake from contact with dust, air, and surfaces. Average intake rates were estimated to be 3.6 ng kg AB - per day (adults) and 12.4 ng kg AB - per day (2 year-old), with neutral PFAS contributing over 80% total PFAS intake. Excluding dietary ingestion, which was not measured, inhalation contributed over 65% of PFAS intake and was dominated by neutral PFAS because fluorotelomer alcohol (FTOH) concentrations in air were several orders of magnitude greater than ionic PFAS concentrations. Perfluorooctanoic acid (PFOA) intake was 6.1 × 10 AB - ng kg AB - per day (adults) and 1.5 × 10 AB - ng kg AB - per day (2 year-old), and biotransformation of 8 : 2 FTOH to PFOA increased this PFOA body burden by 14% (adults) and 17% (2 year-old), suggesting inhalation may also be a meaningful contributor to ionic PFAS exposure through biotransformation. AB - Author manuscript AN - cdc:261930 C4 - PMC12065928 DO - https://doi.org/10.1039/d4em00525b IS - 6 J2 - Environmental Science. Processes & Impacts KW - Fluorocarbons KW - Air Pollution, Indoor KW - Housing KW - Dust KW - Humans KW - Environmental Exposure KW - Environmental Monitoring KW - Caprylates KW - Fluorocarbons KW - Air Pollution, Indoor KW - Environmental Monitoring KW - Humans KW - Housing KW - Environmental Exposure KW - Dust KW - Caprylates LA - eng PY - 2025 T2 - Environmental Science. Processes & Impacts T2 - Environmental Science. Processes & Impacts, Jun-18-2025, v. 27, no. 6 TI - Exposure to Per- and Polyfluoroalkyl Substances (PFAS) in North Carolina Homes: Results From the Indoor PFAS Assessment (IPA) Campaign. VL - 27 UR - https://stacks.cdc.gov/view/cdc/261930 ER -
The Source of All my Joy and All my Stress : Children and Childcare as Underappreciated Sources of Stress That Affect Farm Women.

Becot, Florence ;

Inwood, Shoshanah

January 2025 | Journal of Agromedicine, 2025, v. 30, no. 1

Women have always played a crucial role in agriculture through their work on the farm, caring for the family and the household, and off-farm employment. Yet, like their essential contributions to agriculture, their mental health and well-being have largely been invisible since much of the focus of the mental health in agriculture research has been ...

10/09/2026

Supporting Files

Title : The Source of All my Joy and All my Stress : Children and Childcare as Underappreciated Sources of Stress That Affect Farm Women. Personal Author(s) : Becot, Florence;Inwood, Shoshanah;Budge, Hannah; Published Date : January 2025 Pages in Document : 114-131 (28 pdf pages) Source : Journal of Agromedicine, 2025, v. 30, no. 1 DOI : https://doi.org/10.1080/1059924X.2024.2427800 Journal Title : Journal of Agromedicine
Becot, F., Inwood, S., & Budge, H. (2025). The Source of All my Joy and All my Stress : Children and Childcare as Underappreciated Sources of Stress That Affect Farm Women. Journal of Agromedicine, 30(1). https://doi.org/10.1080/1059924X.2024.2427800

Becot, Florence, Shoshanah Inwood, and Hannah Budge. "The Source of All my Joy and All my Stress : Children and Childcare as Underappreciated Sources of Stress That Affect Farm Women." Journal of Agromedicine 30, no. 1 (2025). https://doi.org/10.1080/1059924X.2024.2427800.

Becot, Florence, et al. "The Source of All my Joy and All my Stress : Children and Childcare as Underappreciated Sources of Stress That Affect Farm Women." Journal of Agromedicine, vol. 30, no. 1, 2025. Stacks. https://doi.org/10.1080/1059924X.2024.2427800.
Export RIS Citation Information. TY - Journal Article AU - Becot, Florence AU - Inwood, Shoshanah AU - Budge, Hannah AB - Women have always played a crucial role in agriculture through their work on the farm, caring for the family and the household, and off-farm employment. Yet, like their essential contributions to agriculture, their mental health and well-being have largely been invisible since much of the focus of the mental health in agriculture research has been on older, male farmers. This paper seeks to address this knowledge gap by focusing on the emotional consequences stemming from the expectations of juggling childcare responsibilities, farm work and managing the household whilst keeping children safe. AB - The data were collected via focus groups and photovoice activity with, respectively, 68 and 33 farm women from Ohio, Wisconsin, and Vermont. AB - The content thematic analysis first indicates that the juggling of multiple roles along with limited support deeply impacted farm women's wellbeing. Worries that the children could get hurt was a major source of stress. Stress and mental health issues connected to children do not lessen as they age but rather shift and become more complex. AB - This article highlights the implications of the lack of investment in farm women's mental wellbeing and their lived realities of caring for children on the farm. Future research should address supply chain and affordability issues, particularly for rural childcare provision. AB - Author manuscript AN - cdc:261929 C4 - PMC12684995 DO - https://doi.org/10.1080/1059924X.2024.2427800 IS - 1 J2 - Journal of Agromedicine KW - Focus Groups KW - Female KW - Farmers KW - Young Adult KW - Mental Health KW - Child KW - Agriculture KW - Farms KW - Male KW - Humans KW - Middle Aged KW - Child, Preschool KW - Stress, Psychological KW - Adult KW - Child Care KW - Childcare KW - children KW - farm safety KW - farm women KW - mental health KW - quality of life KW - triple burden KW - Humans KW - Female KW - Farmers KW - Child Care KW - Adult KW - Child KW - Middle Aged KW - Stress, Psychological KW - Mental Health KW - Focus Groups KW - Child, Preschool KW - Young Adult KW - Male KW - Agriculture KW - Farms LA - eng PY - 2025 T2 - Journal of Agromedicine T2 - Journal of Agromedicine, 2025, v. 30, no. 1 TI - The Source of All my Joy and All my Stress : Children and Childcare as Underappreciated Sources of Stress That Affect Farm Women. VL - 30 UR - https://stacks.cdc.gov/view/cdc/261929 ER -
Adolescent Empathy and Epigenetic Aging in Adulthood: Substance Use as a Mediator.

Goering, Marlon ;

Moore, Amanda

April 2025 | Developmental Psychology, 2025, v. 61, no. 4

Prosocial behavior during adolescence has been associated with better physical health, including slower epigenetic aging. However, little is known about the specific role of empathy in epigenetic aging and the mechanisms explaining this relationship. One such mechanism may be substance use, which is predicted by low empathy and contributes to accel ...

10/09/2026

Supporting Files

Title : Adolescent Empathy and Epigenetic Aging in Adulthood: Substance Use as a Mediator. Personal Author(s) : Goering, Marlon;Moore, Amanda;Barker-Kamps, Malcolm;Patki, Amit;Tiwari, Hemant K.;Mrug, Sylvie; Published Date : April 2025 Pages in Document : 714-725 (26 pdf pages) Source : Developmental Psychology, 2025, v. 61, no. 4 DOI : https://doi.org/10.1037/dev0001893 Journal Title : Developmental Psychology
Goering, M., Moore, A., Barker-Kamps, M., Patki, A., Tiwari, H. K., & Mrug, S. (2025). Adolescent Empathy and Epigenetic Aging in Adulthood: Substance Use as a Mediator. Developmental Psychology, 61(4). https://doi.org/10.1037/dev0001893

Goering, Marlon, Amanda Moore, Malcolm Barker-Kamps, Amit Patki, Hemant K. Tiwari, and Sylvie Mrug. "Adolescent Empathy and Epigenetic Aging in Adulthood: Substance Use as a Mediator." Developmental Psychology 61, no. 4 (2025). https://doi.org/10.1037/dev0001893.

Goering, Marlon, et al. "Adolescent Empathy and Epigenetic Aging in Adulthood: Substance Use as a Mediator." Developmental Psychology, vol. 61, no. 4, 2025. Stacks. https://doi.org/10.1037/dev0001893.
Export RIS Citation Information. TY - Journal Article AU - Goering, Marlon AU - Moore, Amanda AU - Barker-Kamps, Malcolm AU - Patki, Amit AU - Tiwari, Hemant K. AU - Mrug, Sylvie AB - Prosocial behavior during adolescence has been associated with better physical health, including slower epigenetic aging. However, little is known about the specific role of empathy in epigenetic aging and the mechanisms explaining this relationship. One such mechanism may be substance use, which is predicted by low empathy and contributes to accelerated epigenetic aging. Thus, the present study examined whether empathy during early adolescence predicts epigenetic aging in young adulthood and whether substance use in late adolescence and young adulthood mediates this effect. Participants included 343 individuals (58% female, 81% Black, 19% White) who were interviewed at mean ages of 13, 17, and 27 years. Participants self-reported their empathy at Time 1 and their alcohol, tobacco, and cannabis use at Times 2 and 3. At Time 3, epigenetic aging was assessed from salivary DNA using the GrimAge, DunedinPACE, and PhenoAge clocks. A regression analysis demonstrated that higher empathy in early adolescence uniquely predicted lower epigenetic aging on the GrimAge clock in young adulthood even after adjusting for environmental and sociodemographic risk factors. Mediation models revealed that the link between empathy and lower epigenetic aging on all three clocks was mediated by lower tobacco use. These results suggest that higher empathy during early adolescence may contribute to better health throughout the lifespan due to lower tobacco use and slower epigenetic aging. (PsycInfo Database Record (c) 2025 APA, all rights reserved). AB - Author manuscript AN - cdc:261928 C4 - PMC11932777 DO - https://doi.org/10.1037/dev0001893 IS - 4 J2 - Developmental Psychology KW - Adolescent KW - Longitudinal Studies KW - DNA Methylation KW - Female KW - Altruism KW - Parenting KW - Psychology, Adolescent KW - Aging KW - Epigenesis, Genetic KW - CpG Islands KW - Empathy KW - Male KW - Humans KW - Substance-Related Disorders KW - Adolescent Behavior KW - Adult KW - Empathy KW - Substance Use KW - Epigenetic Aging KW - Longitudinal KW - Adolescent KW - Adult KW - Female KW - Humans KW - Male KW - Adolescent Behavior KW - Aging KW - Altruism KW - CpG Islands KW - DNA Methylation KW - Empathy KW - Epigenesis, Genetic KW - Longitudinal Studies KW - Parenting KW - Psychology, Adolescent KW - Substance-Related Disorders LA - eng PY - 2025 T2 - Developmental Psychology T2 - Developmental Psychology, 2025, v. 61, no. 4 TI - Adolescent Empathy and Epigenetic Aging in Adulthood: Substance Use as a Mediator. VL - 61 UR - https://stacks.cdc.gov/view/cdc/261928 ER -
Association of Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination and Reductions in Post COVID Conditions Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in a US Prospective Cohort of Essential Workers.

Mak, Josephine ;

Khan, Sana

March 2025 | The Journal of Infectious Diseases, 2025, v. 231, no. 3

Data are limited on whether vaccination reduces post COVID conditions (PCCs) risk after less severe nonhospitalized coronavirus disease 2019 (COVID-19). This study assessed whether COVID-19 vaccination protected against PCCs in persons with mild initial infections during Delta and Omicron variant predominance.This study utilized a case-control desi ...

10/09/2026

Supporting Files

Title : Association of Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination and Reductions in Post COVID Conditions Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in a US Prospective Cohort of Essential Workers. Personal Author(s) : Mak, Josephine;Khan, Sana;Britton, Amadea;Rose, Spencer;Gwynn, Lisa;Ellingson, Katherine D.;Meece, Jennifer;Feldstein, Leora R.;Tyner, Harmony;Edwards, Laura J.;Thiese, Matthew S.;Naleway, Allison;Gaglani, Manjusha;Solle, Natasha;Burgess, Jefferey L.;Lamberte, Julie Mayo;Shea, Meghan;Hunt-Smith, Taryn;Caban-Martinez, Alberto;Porter, Cynthia;Wiegand, Ryan;Rai, Ramona;Hegmann, Kurt T.;Hollister, James;Fowlkes, Ashley;Wesley, Meredith;Philips, Andrew L.;Rivers, Patrick;Bloodworth, Robin;Newes-Adeyi, Gabriella;Olsho, Lauren E. W.;Yoon, Sarang K.;Saydah, Sharon;Lutrick, Karen; Published Date : March 2025 Pages in Document : 665-676 (20 pdf pages) Source : The Journal of Infectious Diseases, 2025, v. 231, no. 3 DOI : https://doi.org/10.1093/infdis/jiae556 Journal Title : The Journal of Infectious Diseases
Mak, J., Khan, S., Britton, A., Rose, S., Gwynn, L., Ellingson, K. D., Meece, J., Feldstein, L. R., Tyner, H., Edwards, L. J., Thiese, M. S., Naleway, A., Gaglani, M., Solle, N., Burgess, J. L., Lamberte, J. M., Shea, M., Hunt-Smith, T., Caban-Martinez, A., ... Lutrick, K. (2025). Association of Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination and Reductions in Post COVID Conditions Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in a US Prospective Cohort of Essential Workers. The Journal of Infectious Diseases, 231(3). https://doi.org/10.1093/infdis/jiae556

Mak, Josephine, Sana Khan, Amadea Britton, Spencer Rose, Lisa Gwynn, Katherine D. Ellingson, and Jennifer Meece, et al.. "Association of Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination and Reductions in Post COVID Conditions Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in a US Prospective Cohort of Essential Workers." The Journal of Infectious Diseases 231, no. 3 (2025). https://doi.org/10.1093/infdis/jiae556.

Mak, Josephine, et al. "Association of Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination and Reductions in Post COVID Conditions Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in a US Prospective Cohort of Essential Workers." The Journal of Infectious Diseases, vol. 231, no. 3, 2025. Stacks. https://doi.org/10.1093/infdis/jiae556.
Export RIS Citation Information. TY - Journal Article AU - Mak, Josephine AU - Khan, Sana AU - Britton, Amadea AU - Rose, Spencer AU - Gwynn, Lisa AU - Ellingson, Katherine D. AU - Meece, Jennifer AU - Feldstein, Leora R. AU - Tyner, Harmony AU - Edwards, Laura J. AU - Thiese, Matthew S. AU - Naleway, Allison AU - Gaglani, Manjusha AU - Solle, Natasha AU - Burgess, Jefferey L. AU - Lamberte, Julie Mayo AU - Shea, Meghan AU - Hunt-Smith, Taryn AU - Caban-Martinez, Alberto AU - Porter, Cynthia AU - Wiegand, Ryan AU - Rai, Ramona AU - Hegmann, Kurt T. AU - Hollister, James AU - Fowlkes, Ashley AU - Wesley, Meredith AU - Philips, Andrew L. AU - Rivers, Patrick AU - Bloodworth, Robin AU - Newes-Adeyi, Gabriella AU - Olsho, Lauren E. W. AU - Yoon, Sarang K. AU - Saydah, Sharon AU - Lutrick, Karen AB - Data are limited on whether vaccination reduces post COVID conditions (PCCs) risk after less severe nonhospitalized coronavirus disease 2019 (COVID-19). This study assessed whether COVID-19 vaccination protected against PCCs in persons with mild initial infections during Delta and Omicron variant predominance. AB - This study utilized a case-control design, nested within the HEROES-RECOVER cohort. Participants aged ≥18 years with test-confirmed severe acute respiratory syndrome coronavirus disease 2 (SARS-CoV-2) between 28 June 2021 and 14 September 2022 were surveyed for PCCs, defined by symptoms lasting >4 weeks after initial infection. Cases self-reported PCCs and controls self-reported no PCCs. The exposure was messenger RNA (mRNA) COVID-19 vaccination (2 or 3 monovalent doses). Odds of PCCs among vaccinated and unvaccinated persons were compared with logistic regression. AB - Of 936 participants, 23.6% reported PCCs and 83.2% were vaccinated. Participants who received 3 vaccine doses had lower odds of PCC-related gastrointestinal, neurological, and other symptoms compared to unvaccinated participants (adjusted odds ratio [95% confidence interval]: 0.37 [.16-.85], 0.56 [.32-.97], and 0.48 [.25-.91], respectively). AB - COVID-19 vaccination protected against development of PCCs among persons with mild infection during both Delta and Omicron variant predominance, supporting vaccination as an important PCCs prevention tool. AB - Author manuscript AN - cdc:261927 C4 - PMC11913564 DO - https://doi.org/10.1093/infdis/jiae556 IS - 3 J2 - The Journal of Infectious Diseases KW - Female KW - Vaccination KW - Frontline Workers KW - SARS-CoV-2 KW - Prospective Studies KW - Aged KW - Young Adult KW - COVID-19 KW - COVID-19 Vaccines KW - Case-Control Studies KW - Male KW - Middle Aged KW - Humans KW - Adult KW - post-COVID conditions KW - COVID-19 vaccines KW - mRNA vaccines KW - Long COVID KW - COVID-19 KW - Humans KW - COVID-19 KW - Male KW - Female KW - Adult KW - Middle Aged KW - COVID-19 Vaccines KW - SARS-CoV-2 KW - Case-Control Studies KW - Prospective Studies KW - Vaccination KW - Young Adult KW - Aged KW - Frontline Workers LA - eng PY - 2025 T2 - The Journal of Infectious Diseases T2 - The Journal of Infectious Diseases, 2025, v. 231, no. 3 TI - Association of Messenger RNA Coronavirus Disease 2019 (COVID-19) Vaccination and Reductions in Post COVID Conditions Following Severe Acute Respiratory Syndrome Coronavirus 2 Infection in a US Prospective Cohort of Essential Workers. VL - 231 UR - https://stacks.cdc.gov/view/cdc/261927 ER -

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