Aspergillosis Complicating Severe Coronavirus Disease

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Marr, Kieren A. ; Platt, Andrew ; Tornheim, Jeffrey A. ; Zhang, Sean X. ; Datta, Kausik ; Cardozo, Celia ; Garcia-Vidal, Carolina
• Description:
  Aspergillosis complicating severe influenza infection has been increasingly detected worldwide. Recently, coronavirus disease-associated pulmonary aspergillosis (CAPA) has been detected through rapid reports, primarily from centers in Europe. We provide a case series of CAPA, adding 20 cases to the literature, with review of pathophysiology, diagnosis, and outcomes. The syndromes of pulmonary aspergillosis complicating severe viral infections are distinct from classic invasive aspergillosis, which is recognized most frequently in persons with neutropenia and in other immunocompromised persons. Combined with severe viral infection, aspergillosis comprises a constellation of airway-invasive and angio-invasive disease and results in risks associated with poor airway fungus clearance and killing, including virus- or inflammation-associated epithelial damage, systemic immunosuppression, and underlying lung disease. Radiologic abnormalities can vary, reflecting different pathologies. Prospective studies reporting poor outcomes in CAPA patients underscore the urgent need for strategies to improve diagnosis, prevention, and therapy.
• Subjects:
  Coronavirus Infections COVID-19 Humans Pulmonary Aspergillosis Risk Factors SARS-CoV-2
• Source:
  Emerg Infect Dis. 27(1):18-25
• Pubmed ID:
  33084566
• Pubmed Central ID:
  PMC7774554
• Document Type:
  Journal Article
• Volume:
  27
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:111728657b462155bbb75c4f7e41a10a80fae8eaa44d84cb501ddd7e9cda87c4
• Download URL:
  https://stacks.cdc.gov/view/cdc/99985/cdc_99985_DS1.pdf
• File Type:
  [PDF - 1.82 MB ]