Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Wawina-Bokalanga, Tony; Vanmechelen, Bert; Lhermitte, Valentine; Martí-Carreras, Joan; Vergote, Valentijn; ... More +
Wawina-Bokalanga, Tony; Vanmechelen, Bert; Lhermitte, Valentine; Martí-Carreras, Joan; Vergote, Valentijn; Koundouno, Fara Raymond; Akoi-Boré, Joseph; Thom, Ruth; Tipton, Tom; Steeds, Kimberley; Moussa, Kéita Balla; Amento, Ablam; Laenen, Lies; Duraffour, Sophie; Gabriel, Martin; Ruibal, Paula; Hall, Yper; Kader-Kondé, Mandy; Günther, Stephan; Baele, Guy; Muñoz-Fontela, Cesar; Van Weyenbergh, Johan; Carroll, Miles W.; Maes, Piet; Less -
Description:
We investigated the genetic profiles of killer cell immunoglobulin-like receptors (KIRs) in Ebola virus-infected patients. We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). We genotyped KIRs and HLA class I alleles using DNA from uninfected controls, EVD survivors, and persons who died of EVD. The activating 2DS4-003 and inhibitory 2DL5 genes were significantly more common among persons who died of EVD; 2DL2 was more common among survivors. We used logistic regression analysis and Bayesian modeling to identify 2DL2, 2DL5, 2DS4-003, HLA-B-Bw4-Thr, and HLA-B-Bw4-Ile as probably having a significant relationship with disease outcome. Our findings highlight the importance of innate immune response against Ebola virus and show the association between KIRs and the clinical outcome of EVD.
Subject:
[+]
Alleles
Bayes Theorem
Genotype
Hemorrhagic Fever, Ebola
HLA Antigens
Humans
Receptors, KIR

Source:
Emerg Infect Dis. 27(1):76-84;
Pubmed ID:
33350932
Pubmed Central ID:
PMC7774578
Document Type:
Journal Article;
Place as Subject:
Guinea;
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:e4e0d194c75e8b3e1f69533614ef6d5f48f39c15669f71a410c13aa00b8956f3
File Type:

Supporting Files

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  	20-2177-Techapp-s1.pdf	pdf
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