Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus Disease Outcomes

Wawina-Bokalanga, Tony; Vanmechelen, Bert; Lhermitte, Valentine; Martí-Carreras, Joan; Vergote, Valentijn; Koundouno, Fara Raymond; Akoi-Boré, Joseph; Thom, Ruth; Tipton, Tom; Steeds, Kimberley; Moussa, Kéita Balla; Amento, Ablam; Laenen, Lies; Duraffour, Sophie; Gabriel, Martin; Ruibal, Paula; Hall, Yper; Kader-Kondé, Mandy; Günther, Stephan; Baele, Guy; Muñoz-Fontela, Cesar; Van Weyenbergh, Johan; Carroll, Miles W.; Maes, Piet

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Human Diversity of Killer Cell Immunoglobulin-Like Receptors and Human Leukocyte Antigen Class I Alleles and Ebola Virus Disease Outcomes

Jan 2021
By Wawina-Bokalanga, Tony ; Vanmechelen, Bert ; Lhermitte, Valentine ; ...
Source: Emerg Infect Dis. 27(1):76-84

[PDF-968.28 KB]

English

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Details:

Alternative Title:

Emerg Infect Dis
Personal Author:

Wawina-Bokalanga, Tony ; Vanmechelen, Bert ; Lhermitte, Valentine ; Martí-Carreras, Joan ; Vergote, Valentijn ; ... More +

Wawina-Bokalanga, Tony ; Vanmechelen, Bert ; Lhermitte, Valentine ; Martí-Carreras, Joan ; Vergote, Valentijn ; Koundouno, Fara Raymond ; Akoi-Boré, Joseph ; Thom, Ruth ; Tipton, Tom ; Steeds, Kimberley ; Moussa, Kéita Balla ; Amento, Ablam ; Laenen, Lies ; Duraffour, Sophie ; Gabriel, Martin ; Ruibal, Paula ; Hall, Yper ; Kader-Kondé, Mandy ; Günther, Stephan ; Baele, Guy ; Muñoz-Fontela, Cesar ; Van Weyenbergh, Johan ; Carroll, Miles W. ; Maes, Piet Less -
Description:

We investigated the genetic profiles of killer cell immunoglobulin-like receptors (KIRs) in Ebola virus-infected patients. We studied the relationship between KIR-human leukocyte antigen (HLA) combinations and the clinical outcomes of patients with Ebola virus disease (EVD). We genotyped KIRs and HLA class I alleles using DNA from uninfected controls, EVD survivors, and persons who died of EVD. The activating 2DS4-003 and inhibitory 2DL5 genes were significantly more common among persons who died of EVD; 2DL2 was more common among survivors. We used logistic regression analysis and Bayesian modeling to identify 2DL2, 2DL5, 2DS4-003, HLA-B-Bw4-Thr, and HLA-B-Bw4-Ile as probably having a significant relationship with disease outcome. Our findings highlight the importance of innate immune response against Ebola virus and show the association between KIRs and the clinical outcome of EVD.
Subjects:

[+]

Alleles Bayes Theorem Genotype Hemorrhagic Fever, Ebola Hla Antigens Humans Receptors, Kir
Source:

Emerg Infect Dis. 27(1):76-84
Pubmed ID:

33350932
Pubmed Central ID:

PMC7774578
Document Type:

Journal Article
Place as Subject:

Guinea
Location:

Africa
Volume:

27
Issue:

1
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

[+]

urn:sha256:e4e0d194c75e8b3e1f69533614ef6d5f48f39c15669f71a410c13aa00b8956f3
Download URL:

https://stacks.cdc.gov/view/cdc/99981/cdc_99981_DS1.pdf
File Type:

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