Details:

Alternative Title:
Emerg Infect Dis
Personal Author:
Leung, Kenneth Siu-Sing ; Ng, Timothy Ting-Leung ; Wu, Alan Ka-Lun ; Yau, Miranda Chong-Yee ; Lao, Hiu-Yin ; ... More +
Leung, Kenneth Siu-Sing ; Ng, Timothy Ting-Leung ; Wu, Alan Ka-Lun ; Yau, Miranda Chong-Yee ; Lao, Hiu-Yin ; Choi, Ming-Pan ; Tam, Kingsley King-Gee ; Lee, Lam-Kwong ; Wong, Barry Kin-Chung ; Man Ho, Alex Yat ; Yip, Kam-Tong ; Lung, Kwok-Cheung ; Liu, Raymond Wai-To ; Tso, Eugene Yuk-Keung ; Leung, Wai-Shing ; Chan, Man-Chun ; Ng, Yuk-Yung ; Sin, Kit-Man ; Fung, Kitty Sau-Chun ; Chau, Sandy Ka-Yee ; To, Wing-Kin ; Que, Tak-Lun ; Shum, David Ho-Keung ; Yip, Shea Ping ; Yam, Wing Cheong ; Siu, Gilman Kit-Hang Less -
Description:
Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10| substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread.
Subject:
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Adult
Aged
Aged, 80 And Over
Cluster Analysis
Coronavirus Infections
COVID-19
Disease Hotspot
Disease Outbreaks
Evolution, Molecular
Female
Humans
Male
Middle Aged
Mutation
Phylogeny
Phylogeography
SARS-CoV-2
Viroporin Proteins
Whole Genome Sequencing
Young Adult

Source:
Emerg Infect Dis. 27(1):196-204
Pubmed ID:
33350913
Pubmed Central ID:
PMC7774584
Document Type:
Journal Article
Place as Subject:
Hong Kong
Collection(s):
Emerging Infectious Diseases
Main Document Checksum:
[+]
urn:sha256:cf6eebfdfc3dbdaf840db235e147692eacb29d40ffa8464de8ed76097bd3c784
File Type:

Supporting Files

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  	20-1543-Techapp-s1.xlsx	xlsx
  	20-1543-Techapp-s2.pdf	pdf

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