Territorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Leung, Kenneth Siu-Sing ; Ng, Timothy Ting-Leung ; Wu, Alan Ka-Lun ; Yau, Miranda Chong-Yee ; Lao, Hiu-Yin ; Choi, Ming-Pan ; Tam, Kingsley King-Gee ; Lee, Lam-Kwong ; Wong, Barry Kin-Chung ; Man Ho, Alex Yat ; Yip, Kam-Tong ; Lung, Kwok-Cheung ; Liu, Raymond Wai-To ; Tso, Eugene Yuk-Keung ; Leung, Wai-Shing ; Chan, Man-Chun ; Ng, Yuk-Yung ; Sin, Kit-Man ; Fung, Kitty Sau-Chun ; Chau, Sandy Ka-Yee ; To, Wing-Kin ; Que, Tak-Lun ; Shum, David Ho-Keung ; Yip, Shea Ping ; Yam, Wing Cheong ; Siu, Gilman Kit-Hang
• Description:
  Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10| substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread.
• Subjects:
  Adult Aged Aged, 80 And Over Cluster Analysis Coronavirus Infections COVID-19 Disease Hotspot Disease Outbreaks Evolution, Molecular Female Humans Male Middle Aged Mutation Phylogeny Phylogeography SARS-CoV-2 Viroporin Proteins Whole Genome Sequencing Young Adult

  More +
• Source:
  Emerg Infect Dis. 27(1):196-204
• Pubmed ID:
  33350913
• Pubmed Central ID:
  PMC7774584
• Document Type:
  Journal Article
• Place as Subject:
  Hong Kong
• Location:
  Asia
• Volume:
  27
• Issue:
  1
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:cf6eebfdfc3dbdaf840db235e147692eacb29d40ffa8464de8ed76097bd3c784
• Download URL:
  https://stacks.cdc.gov/view/cdc/99977/cdc_99977_DS1.pdf
• File Type:
  [PDF - 1.11 MB ]