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Territorywide Study of Early Coronavirus Disease Outbreak, Hong Kong, China
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Published Date:
January 2021
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Source:Emerg Infect Dis. 27(1):196-204
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Language:English
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[PDF-1.11 MB]
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Alternative Title:Emerg Infect Dis
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Personal Author:
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Description:Initial cases of coronavirus disease in Hong Kong were imported from mainland China. A dramatic increase in case numbers was seen in February 2020. Most case-patients had no recent travel history, suggesting the presence of transmission chains in the local community. We collected demographic, clinical, and epidemiologic data from 50 patients, who accounted for 53.8% of total reported case-patients as of February 28, 2020. We performed whole-genome sequencing to determine phylogenetic relationship and transmission dynamics of severe acute respiratory syndrome coronavirus 2 infections. By using phylogenetic analysis, we attributed the community outbreak to 2 lineages; 1 harbored a common mutation, Orf3a-G251V, and accounted for 88.0% of the cases in our study. The estimated time to the most recent common ancestor of local coronavirus disease outbreak was December 24, 2019, with an evolutionary rate of 3.04 × 10| substitutions/site/year. The reproduction number was 1.84, indicating ongoing community spread.
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Subject:
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Pubmed ID:33350913
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Pubmed Central ID:PMC7774584
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