Major Depression and Adverse Patient-Reported Outcomes in Systemic Lupus Erythematosus: Results from the California Lupus Epidemiology Study

Details

• Alternative Title:
  Arthritis Care Res (Hoboken)
• Personal Author:
  Dietz, Brett ; Katz, Patricia ; Dall'Era, Maria ; Murphy, Louise B ; Lanata, Cristina ; Trupin, Laura ; Criswell, Lindsey A ; Yazdany, Jinoos
• Description:
  Objective:
  
  Health-related quality of life (HRQoL) is reduced in SLE, partly driven by comorbid depression. The association between major depression among those with SLE and HRQoL measured using the National Institutes of Health's Patient-Reported Outcomes Measurement Information System (PROMIS) is not well characterized.
  
  Methods:
  
  Cross-sectional data were obtained from the California Lupus Epidemiology Study (CLUES), a cohort of adults in the San Francisco Bay Area with SLE. We studied the association between major depression (score ≥ 10 on Patient Health Questionnaire [PHQ-8] depression scale) and T-scores (scaled to population mean of 50, SD of 10) on 12 PROMIS domains representing physical, mental, and social health. Mean T-scores in depressed and non-depressed individuals were compared using multiple linear regression models, adjusting for age, sex, race/ethnicity, disease activity, damage, body mass index (BMI), and household income.
  
  Results:
  
  Mean age of the 326 participants was 45 years; approximately 89% were women, 29% white, 23% Hispanic, 10% black, and 36% Asian. One-quarter met criteria for major depression. In multivariable analyses, major depression was independently associated with worse T-scores on all 12 PROMIS domains (p<0.001); compared with those without major depression, depressed individuals scored more than 10 points (1 SD) worse on Fatigue, Sleep Impairment, Negative Psychosocial Impact of Illness, Satisfaction in Discretionary Social Activities, and Satisfaction in Social Roles.
  
  Conclusion:
  
  In individuals with SLE, major depression is associated with markedly worse PROMIS scores in physical, mental, and social domains. Diagnosing and treating depression may help improve HRQoL in individuals with SLE.
  
  
• Subjects:
  Adult Comorbidity Cost Of Illness Cross-Sectional Studies Depressive Disorder, Major Female Humans Lupus Erythematosus, Systemic Male Mental Health Middle Aged Patient Reported Outcome Measures Prospective Studies Quality Of Life San Francisco

  More +
• Source:
  Arthritis Care Res (Hoboken).
• Pubmed ID:
  32741124
• Pubmed Central ID:
  PMC7775294
• Document Type:
  Journal Article
• Funding:
  K24 AR074534/AR/NIAMS NIH HHSUnited States/ ; R18 HS025638/HS/AHRQ HHSUnited States/ ; U01 DP006486/DP/NCCDPHP CDC HHSUnited States/ ; P30 AR070155/AR/NIAMS NIH HHSUnited States/ ; U01 DP005120/DP/NCCDPHP CDC HHSUnited States/ ; U01DP005120/ACL/ACL HHSUnited States/
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a6693d97ddd46a1799a8ef2f2c1ef8dbadbd45afca2f7da0380d5f27a943e0ad
• Download URL:
  https://stacks.cdc.gov/view/cdc/99843/cdc_99843_DS1.pdf
• File Type:
  [PDF - 326.72 KB ]