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Comparison of the incidence of diabetes in United States and Indian youth: An international harmonization of youth diabetes registries
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April 06 2020
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Source: Pediatr Diabetes. 22(1):8-14
[PDF-72.38 KB]
Details:
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Alternative Title:Pediatr Diabetes
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Personal Author:
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Description:Objective:
Comparison of incidence, across diabetes registries, has the potential to inform hypotheses for risk factors. We sought to compare the incidence of type 1 (T1D) and type 2 diabetes (T2D) in the SEARCH for Diabetes in Youth (SEARCH) in the U.S. to the Registry of Diabetes with Young Age at Onset (YDR) in India.
Methods:
We harmonized data from both registries to the Observational Medical Outcomes Partnership (OMOP) Common Data Model (v5). Data were from physician-diagnosed diabetes incident cases <20 years of age (2006–2012). Denominators were from census and membership data. Incidence was calculated for each of the registries and compared by type and within age and sex categories using a 2-sided, skew-corrected inverted score test.
Results:
Incidence of T1D was higher in SEARCH (21.2 cases/100,000 [95% CI:19.9, 22.5]) than YDR (4.9 cases/100,000 [95% CI:4.3, 5.6]). Incidence of T2D was also higher in SEARCH (5.9 cases/100,000 [95% CI:5.3, 6.6] in SEARCH vs 0.5 cases/100,000 [95% CI:0.3, 0.7] in YDR. The age distribution of T1D cases was similar across registries, whereas T2D was higher at an earlier age in SEARCH. Sex differences existed in SEARCH only, with a higher rate of T2D among females.
Conclusion:
The incidence of youth-onset T1D and T2D was significantly different between registries. Additional data are needed to elucidate whether the differences observed represent diagnostic delay, differences in genetic susceptibility, or differences in distribution of risk factors.
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Pubmed ID:32196874
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Pubmed Central ID:PMC7748376
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