Windows of sensitivity to toxic chemicals in the development of the endocrine system: an analysis of ATSDR’s toxicological profile database

Details

• Alternative Title:
  Int J Environ Health Res
• Personal Author:
  Buser, MC ; Pohl, HR ; Abadin, HG
• Description:
  This review utilizes the robust database of literature contained in toxicological profiles developed by the Agency for Toxic Substances and Disease Registry. The aim was to use this database to identify developmental toxicity studies reporting alterations in hormone levels in the developing fetus and offspring and identify windows of sensitivity. We identified 74 oral exposure studies in rats that provided relevant information on 30 chemicals from 21 profiles. Most studies located provided information on thyroid hormones, with fewer studies on anterior pituitary, adrenal medulla, ovaries, and testes. No studies pertaining to hormones of the posterior pituitary, pancreas, or adrenal cortex were located. The results demonstrate that development of the endocrine system may be affected by exposure to environmental contaminants at many different points, including gestational and/or lactational exposure. Moreover, this review demonstrates the need for more developmental toxicity studies focused on the endocrine system and specifically alterations in hormone levels.
• Subjects:
  Animals Databases, Factual Endocrine System Rats
• Keywords:
  Chlorination Development Environmental Exposure Hormones Household Water Treatment In Utero Exposure Safe Water Storage
• Source:
  Int J Environ Health Res. 32(2):437-454
• Pubmed ID:
  32495642
• Pubmed Central ID:
  PMC7714698
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  32
• Issue:
  2
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:f578a5161a1fed9d6084480476e42a33e91e90cfb07a7f306e4f24c5fbe0ce58
• Download URL:
  https://stacks.cdc.gov/view/cdc/98477/cdc_98477_DS1.pdf
• File Type:
  [PDF - 2.23 MB ]