Genomic Epidemiology of Severe Acute Respiratory Syndrome Coronavirus 2, Colombia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Laiton-Donato, Katherine ; Villabona-Arenas, Christian Julián ; Usme-Ciro, José A. ; Franco-Muñoz, Carlos ; Álvarez-Díaz, Diego A. ; Villabona-Arenas, Liz Stephany ; Echeverría-Londoño, Susy ; Cucunubá, Zulma M. ; Franco-Sierra, Nicolás D. ; Flórez, Astrid C. ; Ferro, Carolina ; Ajami, Nadim J. ; Walteros, Diana Marcela ; Prieto, Franklin ; Durán, Carlos Andrés ; Ospina-Martínez, Martha Lucia ; Mercado-Reyes, Marcela
• Description:
  Coronavirus disease (COVID-19) in Colombia was first diagnosed in a traveler arriving from Europe on February 26, 2020. However, limited data are available on the origins and number of introductions of COVID-19 into the country. We sequenced the causative agent of COVID-19, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), from 43 clinical samples we collected, along with another 79 genome sequences available from Colombia. We investigated the emergence and importation routes for SARS-CoV-2 into Colombia by using epidemiologic, historical air travel, and phylogenetic observations. Our study provides evidence of multiple introductions, mostly from Europe, and documents >12 lineages. Phylogenetic findings validate the lineage diversity, support multiple importation events, and demonstrate the evolutionary relationship of epidemiologically linked transmission chains. Our results reconstruct the early evolutionary history of SARS-CoV-2 in Colombia and highlight the advantages of genome sequencing to complement COVID-19 outbreak investigations.
• Subjects:
  Coronavirus Infections COVID-19 Genome, Viral Genomics Humans Phylogeny Reproducibility Of Results SARS-CoV-2
• Source:
  Emerg Infect Dis. 26(12):2854-2862
• Pubmed ID:
  33219646
• Pubmed Central ID:
  PMC7706936
• Document Type:
  Journal Article
• Place as Subject:
  Colombia
• Volume:
  26
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:34271e21475d79665f094a47dc87cae6762672458e35eb74b3d430486ad610b6
• Download URL:
  https://stacks.cdc.gov/view/cdc/98449/cdc_98449_DS1.pdf
• File Type:
  [PDF - 2.17 MB ]