Human-Pathogenic Kasokero Virus in Field-Collected Ticks

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Schuh, Amy J. ; Amman, Brian R. ; Patel, Ketan ; Sealy, Tara K. ; Swanepoel, Robert ; Towner, Jonathan S.
• Description:
  Kasokero virus (KASV; genus Orthonairovirus) was first isolated in 1977 at Uganda Virus Research Institute from serum collected from Rousettus aegyptiacus bats captured at Kasokero Cave, Uganda. During virus characterization studies at the institute, 4 laboratory-associated infections resulted in mild to severe disease. Although orthonairoviruses are typically associated with vertebrate and tick hosts, a tick vector of KASV never has been reported. We tested 786 Ornithodoros (Reticulinasus) faini tick pools (3,930 ticks) for KASV. The ticks were collected from a large R. aegyptiacus bat roosting site in western Uganda. We detected KASV RNA in 43 tick pools and recovered 2 infectious isolates, 1 of which was derived from host blood-depleted ticks. Our findings suggest that KASV is maintained in an enzootic transmission cycle involving O. (R.) faini ticks and R. aegyptiacus bats and has the potential for incidental virus spillover to humans.
• Subjects:
  Arboviruses Argasidae Bats Chiroptera Ecology Human-Pathogenic Kasokero Virus In Field-Collected Ticks Nairoviruses Ornithodoros Research Rousettus Ticks Vector-borne Infections Viruses

  More +
• Source:
  Emerg Infect Dis. 26(12):2944-2950
• Pubmed ID:
  33219649
• Pubmed Central ID:
  PMC7706932
• Document Type:
  Journal Article
• Place as Subject:
  Uganda
• Location:
  Africa
• Volume:
  26
• Issue:
  12
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:12ae110f190bf6485fae437052d87c5bdedeb3e07a3b7ea7f3b24fd81807cb05
• Download URL:
  https://stacks.cdc.gov/view/cdc/98442/cdc_98442_DS1.pdf
• File Type:
  [PDF - 703.26 KB ]