Equine-Like H3 Avian Influenza Viruses in Wild Birds, Chile

Bravo-Vasquez, Nicolas; Yao, Jiangwei; Jimenez-Bluhm, Pedro; Meliopoulos, Victoria; Freiden, Pamela; Sharp, Bridgett; Estrada, Leonardo; Davis, Amy; Cherry, Sean; Livingston, Brandi; Danner, Angela; Schultz-Cherry, Stacey; Hamilton-West, Christopher

i

Equine-Like H3 Avian Influenza Viruses in Wild Birds, Chile

Supporting Files Public Domain

Dec 2020
By Bravo-Vasquez, Nicolas ; Yao, Jiangwei ; Jimenez-Bluhm, Pedro ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Bravo-Vasquez, Nicolas ; Yao, Jiangwei ; Jimenez-Bluhm, Pedro ; Meliopoulos, Victoria ; Freiden, Pamela ; Sharp, Bridgett ; Estrada, Leonardo ; Davis, Amy ; Cherry, Sean ; Livingston, Brandi ; Danner, Angela ; Schultz-Cherry, Stacey ; Hamilton-West, Christopher
Description:

Since their discovery in the United States in 1963, outbreaks of infection with equine influenza virus (H3N8) have been associated with serious respiratory disease in horses worldwide. Genomic analysis suggests that equine H3 viruses are of an avian lineage, likely originating in wild birds. Equine-like internal genes have been identified in avian influenza viruses isolated from wild birds in the Southern Cone of South America. However, an equine-like H3 hemagglutinin has not been identified. We isolated 6 distinct H3 viruses from wild birds in Chile that have hemagglutinin, nucleoprotein, nonstructural protein 1, and polymerase acidic genes with high nucleotide homology to the 1963 H3N8 equine influenza virus lineage. Despite the nucleotide similarity, viruses from Chile were antigenically more closely related to avian viruses and transmitted effectively in chickens, suggesting adaptation to the avian host. These studies provide the initial demonstration that equine-like H3 hemagglutinin continues to circulate in a wild bird reservoir.
Subjects:

Animals Chickens Hemagglutinin Glycoproteins, Influenza Virus Horses Influenza A Virus, H3N8 Subtype Influenza In Birds Phylogeny
Source:

Emerg Infect Dis. 26(12):2887-2898
Pubmed ID:

33219648
Pubmed Central ID:

PMC7706983
Document Type:

Journal Article
Place as Subject:

Chile
Volume:

26
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:9e2c18485b7840b4cccce3ae1e47d28a77d0e45e130794affd89d2e3053afcd4
Download URL:

https://stacks.cdc.gov/view/cdc/98436/cdc_98436_DS1.pdf
File Type:

[PDF - 4.11 MB ]

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.