Risk for Hepatitis E Virus Transmission by Solvent/Detergent–Treated Plasma

Gallian, Pierre; Lhomme, Sébastien; Morel, Pascal; Gross, Sylvie; Mantovani, Carole; Hauser, Lisette; Tinard, Xavier; Pouchol, Elodie; Djoudi, Rachid; Assal, Azzedine; Abravanel, Florence; Izopet, Jacques; Tiberghien, Pierre

i

Risk for Hepatitis E Virus Transmission by Solvent/Detergent–Treated Plasma

Supporting Files Public Domain

Dec 2020
By Gallian, Pierre ; Lhomme, Sébastien ; Morel, Pascal ; ...

File Language:

English

Details

Alternative Title:

Emerg Infect Dis
Personal Author:

Gallian, Pierre ; Lhomme, Sébastien ; Morel, Pascal ; Gross, Sylvie ; Mantovani, Carole ; Hauser, Lisette ; Tinard, Xavier ; Pouchol, Elodie ; Djoudi, Rachid ; Assal, Azzedine ; Abravanel, Florence ; Izopet, Jacques ; Tiberghien, Pierre
Description:

Hepatitis E has emerged as a major transfusion-transmitted infectious risk. Two recipients of plasma from 2 lots (A and B) of pooled solvent/detergent-treated plasma were found to be infected by hepatitis E virus (HEV) that was determined to have been transmitted by the solvent/detergent-treated plasma. HEV RNA viral loads were 433 IU in lot A and 55 IU in lot B. Retrospective studies found that 100% (13/13) of evaluable lot A recipients versus 18% (3/17) of evaluable lot B recipients had been infected by HEV (p<0.001), albeit not necessarily at time of transfusion. Among evaluable recipients, 86% with a transfused HEV RNA load >50,000 IU were infected, most likely by the HEV-containing solvent/detergent-treated plasma, versus only 7% with a transfused HEV RNA load <50,000 IU (p<0.001). Overall, solvent/detergent-treated plasma might harbor HEV. Such an occurrence might result in a dose-dependent risk for transfusion-transmitted hepatitis E.
Subjects:

Blood Donors Hepatitis E Virus HEV Infectious Dose Plasma Research Retrospective Study Risk For Hepatitis E Virus Transmission By Solvent/Detergent–Treated Plasma Solvent/detergent–treated Plasma Transmission Viruses Zoonoses
Source:

Emerg Infect Dis. 26(12):2881-2886
Pubmed ID:

33219652
Pubmed Central ID:

PMC7706953
Document Type:

Journal Article
Place as Subject:

France
Location:

Europe
Volume:

26
Issue:

12
Collection(s):

Emerging Infectious Diseases
Main Document Checksum:

urn:sha256:01b170ce5e338aec4d4c0d8fbef641af1366d7a984554becff9eaecafa8270cd
Download URL:

https://stacks.cdc.gov/view/cdc/98408/cdc_98408_DS1.pdf
File Type:

[PDF - 1.32 MB ]

File Language:

English

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.