External Societal Costs of Antimicrobial Resistance in Humans Attributable to Antimicrobial Use in Livestock

Details

• Alternative Title:
  Annu Rev Public Health
• Personal Author:
  Innes, Gabriel K. ; Randad, Pranay R. ; Korinek, Anton ; Davis, Meghan F. ; Price, Lance B. ; So, Anthony D. ; Heaney, Christopher D.
• Description:
  Antimicrobial use (AMU) in animal agriculture contributes to antimicrobial resistance (AMR) in humans, which imposes significant health and economic costs on society. Economists call these costs negative externalities, societal costs that are not properly reflected in market prices. We review the relevant literature and develop a model to quantify the external costs of AMU in animal agriculture on AMR in humans. Parameters required for this estimate include (|) the health and economic burden of AMR in humans,(|) the impact of AMU in animal agriculture on AMR in animals, (|) the fraction of AMR in humans attributable to animal agriculture, and (|) AMU in animals. We use a well-documented historic case to estimate an externality cost of about US$1,500 per kilogram of fluoroquinolones administered in US broiler chicken production. Enhanced data collection, particularly on the third and fourth parameters, is urgently needed to quantify more fully the externalities of AMU in animal agriculture.
• Subjects:
  Animals Anti-Bacterial Agents Chickens Costs And Cost Analysis Drug Resistance, Bacterial Fluoroquinolones Humans Livestock
• Keywords:
  AMR Animal Agriculture Antimicrobial Resistance Externality Human Health Societal Cost
• Source:
  Annu Rev Public Health. 41:141-157
• Pubmed ID:
  31910712
• Pubmed Central ID:
  PMC7199423
• Document Type:
  Journal Article
• Funding:
  R43 AI141265/AI/NIAID NIH HHSUnited States/ ; T42 OH008428/OH/NIOSH CDC HHSUnited States/ ; R01 AI130066/AI/NIAID NIH HHSUnited States/ ; K01 OD019918/OD/NIH HHSUnited States/ ; R21 AI139784/AI/NIAID NIH HHSUnited States/ ; R01 ES026973/ES/NIEHS NIH HHSUnited States/ ; T32 ES007141/ES/NIEHS NIH HHSUnited States/ ; T42OH008428/ACL/ACL HHSUnited States/
• Volume:
  41
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:012adb379d8b37559fff6e8805991d3c8a8aa6a2f41b2880fe7295dd51d936f7
• Download URL:
  https://stacks.cdc.gov/view/cdc/98085/cdc_98085_DS1.pdf
• File Type:
  [PDF - 487.40 KB ]