Maternal Periconceptional Alcohol Consumption and Congenital Heart Defects

Details

• Alternative Title:
  Birth Defects Res A Clin Mol Teratol
• Personal Author:
  Zhu, Yong ; Romitti, Paul A. ; Conway, Kristin M. Caspers ; Shen, Dereck H. ; Sun, Lixian ; Browne, Marilyn L. ; Botto, Lorenzo D. ; Lin, Angela E. ; Druschel, Charlotte M.
• Description:
  Background:
  
  Congenital heart defects (CHDs) are the leading cause of infant death from birth defects. Animal studies suggest in utero alcohol exposure is a teratogen for cardiogenesis; however, results from epidemiologic studies are mixed.
  
  Methods:
  
  Data from the National Birth Defects Prevention Study were used to estimate associations between CHDs and case (n = 7076) and control (n = 7972) mother reports of periconceptional (1 month before pregnancy through the first trimester) alcohol consumption with expected delivery dates during 1997 to 2007. CHDs were examined by category (conotruncal, septal, left ventricular outflow tract obstruction, and right ventricular outflow tract obstruction, heterotaxy with CHD) and subtype (e.g., tetralogy of Fallot [TOF]). Alcohol measures examined were any consumption, maximum average drinks per month, binge drinking, and alcohol type. Adjusted odds ratios and 95% confidence intervals were estimated using unconditional logistic regression analysis.
  
  Results:
  
  Increased risks, albeit marginally statistically significant, were observed for TOF and each maternal alcohol measure examined and for right ventricular outflow tract obstruction and heterotaxy with CHD and consumption of distilled spirits. Significantly reduced risks were observed for several CHD categories (septal defects, left ventricular outflow tract obstruction, and right ventricular outflow tract obstruction) and some corresponding subtypes with different alcohol measures. Significant risks were not observed for the other CHDs examined.
  
  Conclusion:
  
  Analysis of this large, well-defined study sample did not show statistically significant increased risks between measures of maternal alcohol consumption and most CHDs examined. These findings may reflect, in part, limitations with retrospective exposure assessment or unmeasured confounders. Additional studies with continued improvement in measurement of alcohol consumption are recommended.
  
  
• Subjects:
  Adult Alcohol Alcohol Drinking Article Birth Defects Case-Control Studies Congenital Heart Defects Epidemiology Female Heart Defects, Congenital Humans Male Maternal Exposure Middle Aged Pregnancy Risk Factors United States Young Adult

  More +
• Source:
  Birth Defects Res A Clin Mol Teratol. 103(7):617-629
• Pubmed ID:
  26118863
• Pubmed Central ID:
  PMC7668305
• Document Type:
  Journal Article
• Funding:
  U01DD001035/ACL/ACL HHS/United States ; U01 DD001035/DD/NCBDD CDC HHS/United States ; PA 02081/PHS HHS/United States ; PA 96043/PHS HHS/United States ; U01 DD000492/DD/NCBDD CDC HHS/United States ; P30 ES005605/ES/NIEHS NIH HHS/United States ; U01DD001035/DD/NCBDD CDC HHS/United States ; U01DD000492/DD/NCBDD CDC HHS/United States
• Volume:
  103
• Issue:
  7
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:78fc082d1a45439125db759d6a7aa242eacfb389b687822b9232c7dfe5a6ae24
• Download URL:
  https://stacks.cdc.gov/view/cdc/97305/cdc_97305_DS1.pdf
• File Type:
  [PDF - 187.78 KB ]