Azithromycin to Prevent Pertussis in Household Contacts, Catalonia and Navarre, Spain, 2012–2013

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Alvarez, Josep ; Godoy, Pere ; Plans-Rubio, Pedro ; Camps, Neus ; Carol, Monica ; Carmona, Gloria ; Solano, Ruben ; Rius, Cristina ; Minguell, Sofia ; Barrabeig, Irene ; Sala-Farré, Maria R. ; Rodriguez, Raquel ; Garcia-Cenoz, Manuel ; Muñoz-Almagro, Carmen ; Dominguez, Angela
• Corporate Authors:
  Transmission of Pertussis in Households Working Group
• Description:
  We retrospectively assessed the effectiveness of azithromycin in preventing transmission of pertussis to a patient's household contacts. We also considered the duration between symptom onset in the primary patient and azithromycin administration. We categorized contacts into 4 groups: those treated within <7 days, 8-14 days, 15-21 days, and >21 days after illness onset in the primary patient. We studied 476 primary index patients and their 1,975 household contacts, of whom 4.5% were later identified as having pertussis. When contacts started chemoprophylaxis within <21 days after the primary patient's symptom onset, the treatment was 43.9% effective. Chemoprophylaxis started >14 days after primary patient's symptom onset was less effective. We recommend that contacts of persons with pertussis begin chemoprophylaxis within <14 days after primary patient's symptom onset.
• Subjects:
  Antimicrobials Azithromycin Azithromycin To Prevent Pertussis In Household Contacts, Catalonia And Navarre, Spain, 2012–2013 Bacteria Bordetella Pertussis Chemoprophylaxis Effectiveness Household Contacts Pertussis Prevention Research Respiratory Infections

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• Source:
  Emerg Infect Dis. 26(11):2678-2684
• Pubmed ID:
  33079034
• Pubmed Central ID:
  PMC7588542
• Document Type:
  Journal Article
• Place as Subject:
  Spain
• Location:
  Europe
• Volume:
  26
• Issue:
  11
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:ded2c3777a4c913fd10011e8bbdefa85514123feb513a7b579f35e318b092820
• Download URL:
  https://stacks.cdc.gov/view/cdc/96894/cdc_96894_DS1.pdf
• File Type:
  [PDF - 1.27 MB ]