The effect of steroid treatment on weight in nonambulatory males with Duchenne muscular dystrophy

Details

• Alternative Title:
  Am J Med Genet A
• Personal Author:
  Lamb, Molly M. ; Cai, Bo ; Royer, Julie ; Pandya, Shree ; Soim, Aida ; Valdez, Rodolfo ; DiGuiseppi, Carolyn ; James, Katherine ; Whitehead, Nedra ; Peay, Holly ; Venkatesh, Swamy Y. ; Matthews, Dennis
• Corporate Authors:
  The Muscular Dystrophy Surveillance, Research, and Tracking Network (MD STARnet)
• Description:
  To describe the long-term effect of steroid treatment on weight in nonambulatory males with Duchenne Muscular Dystrophy (DMD), we identified 392 males age 7-29 years with 4,512 weights collected after ambulation loss (176 steroid-naïve and 216 treated with steroids ≥6 months) from the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet). Comparisons were made between the weight growth curves for steroid-naïve males with DMD, steroid-treated males with DMD, and the US pediatric male population. Using linear mixed-effects models adjusted for race/ethnicity and birth year, we evaluated the association between weight-for-age and steroid treatment characteristics (age at initiation, dosing interval, cumulative duration, cumulative dose, type). The weight growth curves for steroid-naïve and steroid-treated nonambulatory males with DMD were wider than the US pediatric male growth curves. Mean weight-for-age z scores were lower in both steroid-naïve (mean = -1.3) and steroid-treated (mean = -0.02) nonambulatory males with DMD, compared to the US pediatric male population. Longer treatment duration and greater cumulative dose were significantly associated with lower mean weight-for-age z scores. Providers should consider the effect of steroid treatment on weight when making postambulation treatment decisions for males with DMD.
• Subjects:
  Adolescent Adrenal Cortex Hormones Adult Article Body Weight Child Corticosteroids Humans Male Muscular Dystrophy Muscular Dystrophy, Duchenne Nonambulatory Walking Weight Young Adult

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• Source:
  Am J Med Genet A. 176(11):2350-2358
• Pubmed ID:
  30256515
• Pubmed Central ID:
  PMC7533648
• Document Type:
  Journal Article
• Funding:
  U01 DD001117/DD/NCBDD CDC HHS/United States ; U01 DD000187/DD/NCBDD CDC HHS/United States ; U01DD001116/ACL/ACL HHS/United States ; DD000190/CC/CDC HHS/United States ; U01 DD000191/DD/NCBDD CDC HHS/United States ; DD000187, DD000189, DD000190, DD000191, DD001116 a/CC/CDC HHS/United States ; DD000189/CC/CDC HHS/United States ; U01 DD000190/DD/NCBDD CDC HHS/United States ; U01DD001117/ACL/ACL HHS/United States ; DD001117/CC/CDC HHS/United States ; DD000191/CC/CDC HHS/United States ; U01 DD000189/DD/NCBDD CDC HHS/United States ; U01 DD001116/DD/NCBDD CDC HHS/United States ; DD001116/CC/CDC HHS/United States ; DD000187/CC/CDC HHS/United States
• Volume:
  176
• Issue:
  11
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:137bea1b94e5d7048391eb7f67439df67904c4f2daacae79dd01bacaf391768c
• Download URL:
  https://stacks.cdc.gov/view/cdc/94884/cdc_94884_DS1.pdf
• File Type:
  [PDF - 318.60 KB ]