Heterologous protection against Crimean-Congo hemorrhagic fever in mice after a single dose of replicon particle vaccine

Details

• Alternative Title:
  Antiviral Res
• Personal Author:
  Spengler, Jessica R. ; Welch, Stephen R. ; Scholte, Florine E.M. ; Coleman-McCray, JoAnn D. ; Harmon, Jessica R. ; Nichol, Stuart T. ; Bergeron, Éric ; Spiropoulou, Christina F.
• Description:
  No vaccines are currently licensed to prevent Crimean-Congo hemorrhagic fever virus (CCHFV) infection, which can cause mild self-limiting clinical signs or severe, often fatal hemorrhagic fever disease. Here we continued investigations into the utility of a single-dose virus replicon particle (VRP) vaccine regimen by assessing protection against Turkey or Oman strains of CCHFV. We found that all mice were completely protected from disease, supporting broad applicability of this platform for CCHFV prevention.
• Keywords:
  Animals Antibodies, Neutralizing Antibodies, Viral Crimean-Congo Hemorrhagic Fever Disease Disease Models, Animal Female Hemorrhagic Fever Hemorrhagic Fever, Crimean Hemorrhagic Fever Virus, Crimean-Congo Heterologous Protection IFNAR−/− Mice Immunity, Heterologous Mice Replicon Replicon Particle Vaccine Viral Vaccines Virion Virus VRP

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• Source:
  Antiviral Res. 170:104573
• Pubmed ID:
  31377243
• Pubmed Central ID:
  PMC6773275
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/ ; R01 AI109008/AI/NIAID NIH HHSUnited States/
• Volume:
  170
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:63bcf8aaf6d35f1137880b2e67ce59de09e26e14f7d34262eded4f2a84758dd0
• Download URL:
  https://stacks.cdc.gov/view/cdc/94463/cdc_94463_DS1.pdf
• File Type:
  [PDF - 1.13 MB ]