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Cardiovascular Risk and Heart Rate Variability in Young Adults with Type 2 Diabetes and Arterial Stiffness: The SEARCH for Diabetes in Youth Study
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10 2020
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Source: J Diabetes Complications. 34(10):107676
Details:
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Alternative Title:J Diabetes Complications
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Personal Author:
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Description:Aims
To evaluate cardiovascular risk factors and heart rate variability (HRV) in young adults with type 2 diabetes and arterial stiffness and to explore the relationship between HRV and arterial stiffness.
Methods
We studied 185 young adults with youth-onset T2D enrolled in the SEARCH for Diabetes in Youth study. Cardiovascular risk factors and HRV were compared between individuals with and without type 2 diabetes and arterial stiffness (defined as a pulse wave velocity greater than the 90th percentile of healthy controls, >6.767 m/s). Semiparametric regression evaluated the independent relationship between HRV and PWV.
Results
Participants with T2D and arterial stiffness were more likely to be older, non-Hispanic Black, have higher systolic and diastolic blood pressure, greater adiposity and obesity-related dyslipidemia (higher triglycerides and lower HDL-C). Participants with T2D arterial stiffness also had lower overall HRV (lower SDNN) with parasympathetic loss (lower RMSSD and PNN50), p<0.05. Lower HRV tended to be but was not significantly associated with arterial stiffness after adjustment for age, race/ethnicity, sex and cardiovascular risk factors (beta coefficient = −1.11, p=0.08).
Conclusions
Youth with T2D and arterial stiffness have a worse cardiovascular risk profile, specifically risk factors related to the metabolic syndrome and lower HRV.
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Subjects:
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Source:
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Pubmed ID:32713707
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Pubmed Central ID:PMC7502460
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Document Type:
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Funding:
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Volume:34
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Issue:10
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Main Document Checksum:
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Download URL:
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File Type:
[PDF-337.82 KB]
