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Adiponectin and arterial stiffness in youth with type 1 diabetes: the SEARCH for Diabetes in Youth Study
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Details:
  • Pubmed ID:
    23155699
  • Pubmed Central ID:
    PMC4343317
  • Description:
    Persons with type 1 diabetes are at increased risk of developing vascular disease. Adiponectin concentrations may play an intermediate role in this process. We sought to determine whether adiponectin is correlated with vascular stiffness in adolescents with type 1 diabetes. Plasma adiponectin, pulse wave velocity (PWV), augmentation index (AIx-75), and brachial distensibility (BrachD) were collected in 225 adolescents. Outcomes were evaluated by sex, and regression models were used to determine whether adiponectin was an independent determinant of arterial stiffness. Males had lower adiponectin levels and stiffer vessels (lower BrachD, p < 0.01) than females. Unadjusted correlations revealed that adiponectin was correlated with BrachD (p < 0.01) but not PWV and AIx-75. After adjustment, adiponectin was not a significant predictor of BrachD. The most consistent predictors of increased stiffness were age, male sex, blood pressure, obesity, and total cholesterol (p < 0.05). Adiponectin's contributions to arterial stiffness appear to be masked by other cardiovascular risk factors in persons with type 1 diabetes.

  • Document Type:
  • Collection(s):
  • Funding:
    1U18DP002709/DP/NCCDPHP CDC HHS/United States
    1UL1RR026314-01/RR/NCRR NIH HHS/United States
    DP-05-069/DP/NCCDPHP CDC HHS/United States
    DP-10-001/DP/NCCDPHP CDC HHS/United States
    M01 RR00069/RR/NCRR NIH HHS/United States
    M01RR00037/RR/NCRR NIH HHS/United States
    P30 DK048520/DK/NIDDK NIH HHS/United States
    P30 DK57516/DK/NIDDK NIH HHS/United States
    PA00097/PHS HHS/United States
    T32 DK063929/DK/NIDDK NIH HHS/United States
    U01 DP000247/DP/NCCDPHP CDC HHS/United States
    U01 DP000248/DP/NCCDPHP CDC HHS/United States
    U18DP000247-06A1/DP/NCCDPHP CDC HHS/United States
    U48/CCU519239/CC/ODCDC CDC HHS/United States
    U48/CCU819241-3/CC/ODCDC CDC HHS/United States
    UL1 RR029882/RR/NCRR NIH HHS/United States
    UL1 TR000077/TR/NCATS NIH HHS/United States
    UL1 TR000423/TR/NCATS NIH HHS/United States
    UL1RR029882/RR/NCRR NIH HHS/United States
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