Adiponectin and arterial stiffness in youth with type 1 diabetes: the SEARCH for Diabetes in Youth Study

Details

• Alternative Title:
  J Pediatr Endocrinol Metab
• Personal Author:
  Shah, Amy S. ; Dolan, Lawrence M. ; Lauer, Abigail ; Davis, Cralen ; Dabelea, Dana ; Daniels, Stephen R. ; Hamman, Richard F. ; Marcovina, Santica ; Wadwa, R. Paul ; Urbina, Elaine M.
• Description:
  Persons with type 1 diabetes are at increased risk of developing vascular disease. Adiponectin concentrations may play an intermediate role in this process. We sought to determine whether adiponectin is correlated with vascular stiffness in adolescents with type 1 diabetes. Plasma adiponectin, pulse wave velocity (PWV), augmentation index (AIx-75), and brachial distensibility (BrachD) were collected in 225 adolescents. Outcomes were evaluated by sex, and regression models were used to determine whether adiponectin was an independent determinant of arterial stiffness. Males had lower adiponectin levels and stiffer vessels (lower BrachD, p < 0.01) than females. Unadjusted correlations revealed that adiponectin was correlated with BrachD (p < 0.01) but not PWV and AIx-75. After adjustment, adiponectin was not a significant predictor of BrachD. The most consistent predictors of increased stiffness were age, male sex, blood pressure, obesity, and total cholesterol (p < 0.05). Adiponectin's contributions to arterial stiffness appear to be masked by other cardiovascular risk factors in persons with type 1 diabetes.
• Subjects:
  Adiponectin Adolescent Age Factors Blood Pressure Child Cohort Studies Diabetes Mellitus, Type 1 Female Hemodynamics Humans Male Pulse Wave Analysis Regression Analysis Vascular Stiffness

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• Keywords:
  Adiponectin Arterial Stiffness Diabetes Pediatrics
• Source:
  J Pediatr Endocrinol Metab. 2012; 25(0):717-721
• Pubmed ID:
  23155699
• Pubmed Central ID:
  PMC4343317
• Document Type:
  Journal Article
• Funding:
  DP-05-069/DP/NCCDPHP CDC HHSUnited States/ ; T32 DK063929/DK/NIDDK NIH HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; M01 RR000037/RR/NCRR NIH HHSUnited States/ ; DP-10-001/DP/NCCDPHP CDC HHSUnited States/ ; P30 DK57516/DK/NIDDK NIH HHSUnited States/ ; U18 DP002709/DP/NCCDPHP CDC HHSUnited States/ ; U48/CCU819241-3/CC/CDC HHSUnited States/ ; UL1 TR000077/TR/NCATS NIH HHSUnited States/ ; UL1 TR000423/TR/NCATS NIH HHSUnited States/ ; PA00097/PHS HHSUnited States/ ; P30 DK057516/DK/NIDDK NIH HHSUnited States/ ; HIR 10-001/HX/HSRD VAUnited States/ ; 1U18DP002709/DP/NCCDPHP CDC HHSUnited States/ ; M01RR00037/RR/NCRR NIH HHSUnited States/ ; U01 DP000247/DP/NCCDPHP CDC HHSUnited States/ ; P30 DK048520/DK/NIDDK NIH HHSUnited States/ ; M01 RR000069/RR/NCRR NIH HHSUnited States/ ; U48/CCU519239/CC/CDC HHSUnited States/ ; 1UL1RR026314-01/RR/NCRR NIH HHSUnited States/ ; U18DP000247-06A1/DP/NCCDPHP CDC HHSUnited States/ ; UL1 RR029882/RR/NCRR NIH HHSUnited States/ ; M01 RR00069/RR/NCRR NIH HHSUnited States/ ; UL1 RR026314/RR/NCRR NIH HHSUnited States/ ; UL1RR029882/RR/NCRR NIH HHSUnited States/
• Volume:
  25
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:65544739a7033134fc71b8e6ca454c9dea296101e8f36093e8db5ca2bacc75b8
• Download URL:
  https://stacks.cdc.gov/view/cdc/33729/cdc_33729_DS1.pdf
• File Type:
  [PDF - 156.25 KB ]