Cardiovascular Risk and Heart Rate Variability in Young Adults with Type 2 Diabetes and Arterial Stiffness: The SEARCH for Diabetes in Youth Study

Details

• Alternative Title:
  J Diabetes Complications
• Personal Author:
  Shah, Amy Sanghavi ; Jaiswal, Mamta ; Dabelea, Dana ; Divers, Jasmin ; Isom, Scott ; Liese, Angela D ; Lawrence, Jean M ; Kim, Grace ; Urbina, Elaine M.
• Description:
  Aims
  
  To evaluate cardiovascular risk factors and heart rate variability (HRV) in young adults with type 2 diabetes and arterial stiffness and to explore the relationship between HRV and arterial stiffness.
  
  Methods
  
  We studied 185 young adults with youth-onset T2D enrolled in the SEARCH for Diabetes in Youth study. Cardiovascular risk factors and HRV were compared between individuals with and without type 2 diabetes and arterial stiffness (defined as a pulse wave velocity greater than the 90th percentile of healthy controls, >6.767 m/s). Semiparametric regression evaluated the independent relationship between HRV and PWV.
  
  Results
  
  Participants with T2D and arterial stiffness were more likely to be older, non-Hispanic Black, have higher systolic and diastolic blood pressure, greater adiposity and obesity-related dyslipidemia (higher triglycerides and lower HDL-C). Participants with T2D arterial stiffness also had lower overall HRV (lower SDNN) with parasympathetic loss (lower RMSSD and PNN50), p<0.05. Lower HRV tended to be but was not significantly associated with arterial stiffness after adjustment for age, race/ethnicity, sex and cardiovascular risk factors (beta coefficient = −1.11, p=0.08).
  
  Conclusions
  
  Youth with T2D and arterial stiffness have a worse cardiovascular risk profile, specifically risk factors related to the metabolic syndrome and lower HRV.
  
  
• Subjects:
  Adolescents Arterial Stiffness Article Heart Rate Variability Pediatrics Type 2 Diabetes
• Source:
  J Diabetes Complications. 34(10):107676
• Pubmed ID:
  32713707
• Pubmed Central ID:
  PMC7502460
• Document Type:
  Journal Article
• Funding:
  P30 DK057516/DK/NIDDK NIH HHSUnited States/ ; U01 DP000247/DP/NCCDPHP CDC HHSUnited States/ ; U18 DP002710/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006138/ACL/ACL HHSUnited States/ ; UL1 TR000154/TR/NCATS NIH HHSUnited States/ ; U18 DP002714/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000248/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000244/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR000062/TR/NCATS NIH HHSUnited States/ ; U18DP006134/ACL/ACL HHSUnited States/ ; U18 DP002709/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006131/ACL/ACL HHSUnited States/ ; HIR 10-001/HX/HSRD VAUnited States/ ; U18DP006139/ACL/ACL HHSUnited States/ ; UC4 DK108173/DK/NIDDK NIH HHSUnited States/ ; UL1 TR001425/TR/NCATS NIH HHSUnited States/ ; UL1 TR002319/TR/NCATS NIH HHSUnited States/ ; U18 DP006139/DP/NCCDPHP CDC HHSUnited States/ ; UL1 TR000077/TR/NCATS NIH HHSUnited States/ ; R01 DK127208/DK/NIDDK NIH HHSUnited States/ ; UL1 TR000423/TR/NCATS NIH HHSUnited States/ ; U18DP006136/ACL/ACL HHSUnited States/ ; U01 DP000250/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000246/DP/NCCDPHP CDC HHSUnited States/ ; U01 DP000254/DP/NCCDPHP CDC HHSUnited States/ ; U18DP006133/ACL/ACL HHSUnited States/ ; U18 DP002708/DP/NCCDPHP CDC HHSUnited States/
• Volume:
  34
• Issue:
  10
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:af25aa9d98cf121cb4d2528f1b7a7cf3232a66b4363fb4b65e4dc26a8aef5194
• Download URL:
  https://stacks.cdc.gov/view/cdc/94029/cdc_94029_DS1.pdf
• File Type:
  [PDF - 337.82 KB ]