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Cytomegalovirus Infection among Infants in Neonatal Intensive Care Units, California, 2005–2016
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March 20 2019
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Source: Am J Perinatol.
[PDF-107.46 KB]
Details:
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Alternative Title:Am J Perinatol
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Description:Aim:
To assess trends in cytomegalovirus (CMV) infection reported among infants in California neonatal intensive care units (NICUs) during 2005–2016.
Methods:
The California Perinatal Quality Care Collaborative collects data on all very low birth weight (VLBW, birth weight ≤1500g) and acutely ill infants >1500g, representing 92% of NICUs in California. We compared clinical characteristics and length of hospital stay among infants with and without reported CMV infection (CMV-positive viral culture or polymerase chain reaction).
Results:
During 2005–2016, CMV infection was reported in 174 VLBW infants and 145 infants >1500g, or 2.7 (range: 1.5–4.7) and 1.2 (range: 0.8–1.7) per 1,000 infants, respectively (no significant annual trend). Among infants >1500g, 12 (8%) vs. 4,928 (4%) of those reported with vs. without CMV infection died (P<0.05). The median hospital stay was significantly longer among infants reported with vs. without CMV infection for both VLBW infants (98 vs. 46 days) and infants >1500g (61 vs. 14 days) (P<0.001).
Conclusions:
Reports of CMV infection remained stable over a 12-year period. Although we were not able to assess whether infection was congenital or postnatal, CMV infection among infants >1500g was associated with increased mortality.
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Pubmed ID:30895580
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Pubmed Central ID:PMC6754307
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