Cytomegalovirus Infection among Infants in California Neonatal Intensive Care Units, 2005–2010

Lanzieri, Tatiana M.; Bialek, Stephanie R.; Bennett, Mihoko V.; Gould, Jeffrey B.

doi:10.1515/jpm-2013-0183

i

Cytomegalovirus Infection among Infants in California Neonatal Intensive Care Units, 2005–2010

Supporting Files

May 2014
By Lanzieri, Tatiana M. ; Bialek, Stephanie R. ; Bennett, Mihoko V. ; ...

Details

Alternative Title:

J Perinat Med
Personal Author:

Lanzieri, Tatiana M. ; Bialek, Stephanie R. ; Bennett, Mihoko V. ; Gould, Jeffrey B.
Description:

Aim

Assess the burden of congenital and perinatal cytomegalovirus (CMV) disease among infants hospitalized in neonatal intensive care units (NICUs).

Methods

CMV infection was defined as a report of positive CMV viral culture or PCR at any time since birth in an infant hospitalized in a NICU reporting to California Perinatal Quality Care Collaborative during 2005–2010.

Results

156 (1.7 per 1000) infants were reported with CMV infection, representing an estimated 5% of the expected number of live births with symptomatic CMV disease. Prevalence was higher among infants with younger gestational ages and lower birth weights. Infants with CMV infection had significantly longer hospital stays; 14 (9%) died.

Conclusions

Reported prevalence of CMV infection in NICUs represents a fraction of total expected disease burden from CMV in the newborn period, likely resulting from underdiagnosis and milder symptomatic cases that do not require NICU care. More complete ascertainment of infants with congenital CMV infection that would benefit from antiviral treatment may reduce the burden of CMV disease in this population.
Subjects:

Acquired Infection Article California Congenital Infection Cytomegalovirus Cytomegalovirus Infections Humans Infant, Newborn Infant, Very Low Birth Weight Intensive Care Units, Neonatal Premature Infant Prevalence Very Low Birth Weight Infant
Source:

J Perinat Med. 42(3):393-399.
Pubmed ID:

24334425
Pubmed Central ID:

PMC4834882
Document Type:

Journal Article
Funding:

CC999999/Intramural CDC HHS/United States
Volume:

42
Issue:

3
Collection(s):

CDC Public Access
Main Document Checksum:

urn:sha256:c52cdd2bfc4f37dda22bddc228b440720a2b3874726e4b07c1046aa8ef024118
Download URL:

https://stacks.cdc.gov/view/cdc/38975/cdc_38975_DS1.pdf
File Type:

[PDF - 296.32 KB ]

ON THIS PAGE

Details Supporting Files

CDC STACKS serves as an archival repository of CDC-published products including scientific findings, journal articles, guidelines, recommendations, or other public health information authored or co-authored by CDC or funded partners.

As a repository, CDC STACKS retains documents in their original published format to ensure public access to scientific information.