Details:

Alternative Title:
MMWR Morb Mortal Wkly Rep
Personal Author:
Godfred-Cato, Shana ; Bryant, Bobbi ; Leung, Jessica ; Oster, Matthew E. ; Conklin, Laura ; ... More +
Godfred-Cato, Shana ; Bryant, Bobbi ; Leung, Jessica ; Oster, Matthew E. ; Conklin, Laura ; Abrams, Joseph ; Roguski, Katherine ; Wallace, Bailey ; Prezzato, Emily ; Koumans, Emilia H. ; Lee, Ellen H. ; Geevarughese, Anita ; Lash, Maura K. ; Reilly, Kathleen H. ; Pulver, Wendy P. ; Thomas, Deepam ; Feder, Kenneth A. ; Hsu, Katherine K. ; Plipat, Nottasorn ; Richardson, Gillian ; Reid, Heather ; Lim, Sarah ; Schmitz, Ann ; Pierce, Timmy ; Hrapcak, Susan ; Datta, Deblina ; Morris, Sapna Bamrah ; Clarke, Kevin ; Belay, Ermias Less -
Corporate Authors:
California MIS-C Response Team
Description:
In April 2020, during the peak of the coronaVirus disease 2019 (COVID-19) pandemic in Europe, a cluster of children with hyperinflammatory shock with features similar to Kawasaki disease and toxic shock syndrome was reported in England* (1). The patients' signs and symptoms were temporally associated with COVID-19 but presumed to have developed 2-4 weeks after acute COVID-19; all children had serologic evidence of infection with SARS-CoV-2, the Virus that causes COVID-19 (1). The clinical signs and symptoms present in this first cluster included fever, rash, conjunctivitis, peripheral edema, gastrointestinal symptoms, shock, and elevated markers of inflammation and cardiac damage (1). On May 14, 2020, CDC published an online Health Advisory that summarized the manifestations of reported multisystem inflammatory syndrome in children (MIS-C), outlined a case definition,| and asked clinicians to report suspected U.S. cases to local and state health departments. As of July 29, a total of 570 U.S. MIS-C patients who met the case definition had been reported to CDC. A total of 203 (35.6%) of the patients had a clinical course consistent with previously published MIS-C reports, characterized predominantly by shock, cardiac dysfunction, abdominal pain, and markedly elevated inflammatory markers, and almost all had positive SARS-CoV-2 test results. The remaining 367 (64.4%) of MIS-C patients had manifestations that appeared to overlap with acute COVID-19 (2-4), had a less severe clinical course, or had features of Kawasaki disease.| Median duration of hospitalization was 6 days; 364 patients (63.9%) required care in an intensive care unit (ICU), and 10 patients (1.8%) died. As the COVID-19 pandemic continues to expand in many jurisdictions, clinicians should be aware of the signs and symptoms of MIS-C and report suspected cases to their state or local health departments; Analysis of reported cases can enhance understanding of MIS-C and improve characterization of the illness for early detection and treatment.
Subject:
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Adolescent Child Child, Preschool CoronaVirus Infections COVID-19 Female Full Report Humans Male Pandemics Pneumonia, Viral Systemic Inflammatory Response Syndrome
Source:
MMWR Morb Mortal Wkly Rep. 69(32):1074-1080
Pubmed ID:
32790663
Pubmed Central ID:
PMC7440126
Document Type:
Journal Article
Place as Subject:
United States
Collection(s):
Morbidity and Mortality Weekly Report (MMWR)
Main Document Checksum:
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urn:sha256:4d424b118f3ebaf567036842c70ee8acc26adf45d771e1594de3adb2194c7b24
Download URL:
https://stacks.cdc.gov/view/cdc/92566/cdc_92566_DS1.pdf
File Type:

Supporting Files

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