Investigation and Serologic Follow-Up of Contacts of an Early Confirmed Case-Patient with COVID-19, Washington, USA

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Chu, Victoria T. ; Freeman-Ponder, Brandi ; Lindquist, Scott ; Spitters, Christopher ; Kawakami, Vance ; Dyal, Jonathan W. ; Clark, Shauna ; Bruce, Hollianne ; Duchin, Jeffrey S. ; DeBolt, Chas ; Podczervinski, Sara ; D’Angeli, Marisa ; Pettrone, Kristen ; Zacks, Rachael ; Vahey, Grace ; Holshue, Michelle L. ; Lang, Misty ; Burke, Rachel M. ; Rolfes, Melissa A. ; Marlow, Mariel ; Midgley, Claire M. ; Lu, Xiaoyan ; Lindstrom, Stephen ; Hall, Aron J. ; Fry, Alicia M. ; Thornburg, Natalie J. ; Gerber, Susan I. ; Pillai, Satish K. ; Biggs, Holly M.
• Description:
  We describe the contact investigation for an early confirmed case of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), in the United States. Contacts of the case-patient were identified, actively monitored for symptoms, interviewed for a detailed exposure history, and tested for SARS-CoV-2 infection by real-time reverse transcription PCR (rRT-PCR) and ELISA. Fifty contacts were identified and 38 (76%) were interviewed, of whom 11 (29%) reported unprotected face-to-face interaction with the case-patient. Thirty-seven (74%) had respiratory specimens tested by rRT-PCR, and all tested negative. Twenty-three (46%) had ELISA performed on serum samples collected ≈6 weeks after exposure, and none had detectable antibodies to SARS-CoV-2. Among contacts who were tested, no secondary transmission was identified in this investigation, despite unprotected close interactions with the infectious case-patient.
• Subjects:
  Adolescent Adult Aged Betacoronavirus Child Child, Preschool Clinical Laboratory Techniques Contact Tracing Coronavirus Infections COVID-19 Enzyme-Linked Immunosorbent Assay Female Humans Infant Infant, Newborn Male Middle Aged Pandemics Pneumonia, Viral Public Health Reverse Transcriptase Polymerase Chain Reaction Travel

  More +
• Source:
  Emerg Infect Dis. 26(8):1671-1678
• Pubmed ID:
  32470316
• Pubmed Central ID:
  PMC7392438
• Document Type:
  Journal Article
• Place as Subject:
  Washington
• Location:
  North America
• Volume:
  26
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:9abf65973a1a3a76b70cece9d7067d3b9a394455765af0144dedebf8c27f7fa5
• Download URL:
  https://stacks.cdc.gov/view/cdc/91576/cdc_91576_DS1.pdf
• File Type:
  [PDF - 983.40 KB ]