Naturally Acquired Human Plasmodium cynomolgi and P. knowlesi Infections, Malaysian Borneo

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Raja, Thamayanthi Nada ; Hu, Ting Huey ; Kadir, Khamisah Abdul ; Mohamad, Dayang Shuaisah Awang ; Rosli, Nawal ; Wong, Lolita Lin ; Hii, King Ching ; Simon Divis, Paul Cliff ; Singh, Balbir
• Description:
  To monitor the incidence of Plasmodium knowlesi infections and determine whether other simian malaria parasites are being transmitted to humans, we examined 1,047 blood samples from patients with malaria at Kapit Hospital in Kapit, Malaysia, during June 24, 2013-December 31, 2017. Using nested PCR assays, we found 845 (80.6%) patients had either P. knowlesi monoinfection (n = 815) or co-infection with other Plasmodium species (n = 30). We noted the annual number of these zoonotic infections increased greatly in 2017 (n = 284). We identified 6 patients, 17-65 years of age, with P. cynomolgi and P. knowlesi co-infections, confirmed by phylogenetic analyses of the Plasmodium cytochrome c oxidase subunit 1 gene sequences. P. knowlesi continues to be a public health concern in the Kapit Division of Sarawak, Malaysian Borneo. In addition, another simian malaria parasite, P. cynomolgi, also is an emerging cause of malaria in humans.
• Subjects:
  Malaria Malaysian Borneo Naturally Acquired Human Plasmodium Cynomolgi And P. Knowlesi Infections, Malaysian Borneo Parasites Parasitic Diseases Plasmodium Cynomolgi Plasmodium Knowlesi Research Zoonoses
• Source:
  Emerg Infect Dis. 26(8):1801-1809
• Pubmed ID:
  32687020
• Pubmed Central ID:
  PMC7392409
• Document Type:
  Journal Article
• Volume:
  26
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:3a48e425fc97c4b92aa8135f652bc1e773f432a7633fc538f44129d17f99bcb8
• Download URL:
  https://stacks.cdc.gov/view/cdc/91552/cdc_91552_DS1.pdf
• File Type:
  [PDF - 2.19 MB ]