Population Genomic Structure and Recent Evolution of Plasmodium knowlesi, Peninsular Malaysia

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Hocking, Suzanne E. ; Divis, Paul C.S. ; Kadir, Khamisah A. ; Singh, Balbir ; Conway, David J.
• Description:
  Most malaria in Malaysia is caused by Plasmodium knowlesi parasites through zoonotic infection from macaque reservoir hosts. We obtained genome sequences from 28 clinical infections in Peninsular Malaysia to clarify the emerging parasite population structure and test for evidence of recent adaptation. The parasites all belonged to a major genetic population of P. knowlesi (cluster 3) with high genomewide divergence from populations occurring in Borneo (clusters 1 and 2). We also observed unexpected local genetic subdivision; most parasites belonged to 2 subpopulations sharing a high level of diversity except at particular genomic regions, the largest being a region of chromosome 12, which showed evidence of recent directional selection. Surprisingly, we observed a third subpopulation comprising P. knowlesi infections that were almost identical to each other throughout much of the genome, indicating separately maintained transmission and recent genetic isolation. Each subpopulation could evolve and present a broader health challenge in Asia.
• Subjects:
  Borneo Epidemiology Genomics Malaria Malaysia Mosquito-borne Diseases Mosquitoes Parasites Parasitic Infections Peninsular Malaysia Plasmodium Knowlesi Population Genetics Population Genomic Structure And Recent Evolution Of Plasmodium Knowlesi, Peninsular Malaysia Research Selection Sequencing Transmission Vector-borne Diseases Zoonoses

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• Source:
  Emerg Infect Dis. 26(8):1749-1758
• Pubmed ID:
  32687018
• Pubmed Central ID:
  PMC7392424
• Document Type:
  Journal Article
• Volume:
  26
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:0cb3aa8bfb50b604047261af05b755d72e694c25d84d1840fe2a361fac3d8c5b
• Download URL:
  https://stacks.cdc.gov/view/cdc/91522/cdc_91522_DS1.pdf
• File Type:
  [PDF - 3.23 MB ]