Tuberculosis in Internationally Displaced Children Resettling in Harris County, Texas, USA, 2010–20151

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Lamb, Gabriella S. ; Cruz, Andrea T. ; Camp, Elizabeth A. ; Javier, Michelle ; Montour, Jessica ; Piper, Tamisha ; Shah, Umair A. ; Starke, Jeffrey R.
• Description:
  US guidelines have recommended testing children emigrating from high tuberculosis-incidence countries with interferon-gamma release assays (IGRAs) or tuberculin skin tests (TSTs). We describe the Harris County (Texas) Public Health Refugee Health Screening Program's testing results during 2010-2015 for children <18 years of age: 5,990 were evaluated, and 5,870 (98%) were tested. Overall, 364 (6.2%) children had >1 positive test: 143/1,842 (7.8%) were tested with TST alone, 129/3,730 (3.5%) with IGRA alone, and 92/298 (30.9%) with both TST and IGRA. Region of origin and younger age were associated with positive TST or IGRA results. All children were more likely to have positive results for TST than for IGRA (OR 2.92, 95% CI 2.37-3.59). Discordant test results were common (20%) and most often were TST+/IGRA- (95.0%), likely because of bacillus Calmette-Guérin vaccination. Finding fewer false positives supports the 2018 change in US immigration guidelines that recommends using IGRAs for recently immigrated children.
• Subjects:
  Child Child, Preschool Humans Incidence Interferon-Gamma Release Tests Latent Tuberculosis Tuberculin Test Tuberculosis
• Source:
  Emerg Infect Dis. 26(8):1686-1694
• Pubmed ID:
  32687465
• Pubmed Central ID:
  PMC7392435
• Document Type:
  Journal Article
• Place as Subject:
  Texas
• Location:
  North America
• Volume:
  26
• Issue:
  8
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6dd19d97e6d6f4ff3b1c2a0a577165275af737e089ff858f8a504d7b93eca925
• Download URL:
  https://stacks.cdc.gov/view/cdc/91521/cdc_91521_DS1.pdf
• File Type:
  [PDF - 710.90 KB ]