The role of obesity in the relation between total water intake and urine osmolality in US adults, 2009–20121–3

Details

• Alternative Title:
  Am J Clin Nutr
• Personal Author:
  Rosinger, Asher Y ; Lawman, Hannah G ; Akinbami, Lara J ; Ogden, Cynthia L
• Description:
  Background
  
  Adequate water intake is critical to physiologic and cognitive functioning. Although water requirements increase with body size, it remains unclear whether weight status modifies the relation between water intake and hydration status.
  
  Objective
  
  We examined how the association between water intake and urine osmolality, which is a hydration biomarker, varied by weight status.
  
  Design
  
  NHANES cross-sectional data (2009–2012) were analyzed in 9601 nonpregnant adults aged ≥20 y who did not have kidney failure. Weight status was categorized with the use of body mass index on the basis of measured height and weight (underweight or normal weight, overweight, and obesity). Urine osmolality was determined with the use of freezing-point depression osmometry. Hypohydration was classified according to the following age-dependent formula: ≥831 mOsm/kg – [3.4 × (age − 20 y)]. Total water intake was determined with the use of a 24-h dietary recall and was dichotomized as adequate or low on the basis of the Institute of Medicine’s adequate intake recommendations for men and women (men: ≥3.7 or <3.7 L; nonlactating women: ≥2.7 or <2.7 L; lactating women: ≥3.8 or <3.8 L for adequate or low intakes, respectively). We tested interactions and conducted linear and log-binomial regressions.
  
  Results
  
  Total water intake (P = 0.002), urine osmolality (P < 0.001), and hypohydration prevalence (P < 0.001) all increased with higher weight status. Interactions between weight status and water intake status were significant in linear (P = 0.005) and log-binomial (P = 0.015) models, which were then stratified. The prevalence ratio of hypohydration between subjects with adequate water intake and those with low water intake was 0.56 (95% CI: 0.43, 0.73) in adults who were underweight or normal weight, 0.67 (95% CI: 0.57, 0.79) in adults who were overweight, and 0.78 (95% CI: 0.70, 0.88) in adults who were obese.
  
  Conclusion
  
  On a population level, obesity modifies the association between water intake and hydration status.
  
  
• Subjects:
  Adult Biomarkers Body Mass Index Body Weight Cross-Sectional Studies Dehydration Drinking Female Humans Male Mental Recall Middle Aged Nutrition Surveys Obesity Osmolar Concentration Prevalence Sensitivity And Specificity Urine Young Adult

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• Keywords:
  Effect Modification Hydration Status NHANES Obesity Water Intake
• Source:
  Am J Clin Nutr. 104(6):1554-1561
• Pubmed ID:
  27935519
• Pubmed Central ID:
  PMC7392307
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  104
• Issue:
  6
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:732bdc0c27b5807f10903269e3ed6812fcae56a8264c5233648c6bfc94fc54b1
• Download URL:
  https://stacks.cdc.gov/view/cdc/91325/cdc_91325_DS1.pdf
• File Type:
  [PDF - 996.02 KB ]