Use of Medications Associated with Weight Change Among Participants in the All of Us Research Program

Details

• Alternative Title:
  Clin Obes
• Personal Author:
  Almazan, Erik ; Schwartz, Jessica L. ; Gudzune, Kimberly A.
• Description:
  Our objective was to describe the use of medications associated with weight change among US adults with overweight/obesity, including anti-obesity medications (AOMs), weight-loss-promoting and weight-gain-promoting medications. We performed a cross-sectional analysis of data from the nationwide All of Us Research Programme. We included adults with measured body mass index (BMI) ≥ 27 kg/m| enrolled between 2018 and 2022 across the United States. We used linked electronic health record data to determine medication use ±12 months of BMI measure. Our 132 057 participants had mean age 54 years and mean BMI 34 kg/m| ; 60% of participants were women, 62% White, and 32% Black. Only 1% used any AOM, and 14% used at least one weight-loss-promoting medication. We found that 36% used at least one weight-gain-promoting medication, and approximately 20% used multiple weight-gain-promoting medications. While AOMs are underutilized by participants with overweight/obesity, weight-gain-promoting medication use is common. Our results raise concern about potential iatrogenic weight gain from medications. Future research is needed to estimate the long-term effect of weight-gain-promoting medications on weight status and determine whether weight-loss benefits occur with their discontinuation. Clinician education on AOMs and weight-loss-promoting medications may be needed to increase their use.
• Subjects:
  Adult Anti-Obesity Agents Body Mass Index Cross-Sectional Studies Female Humans Male Middle Aged Obesity Overweight Population Health United States Weight Gain

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• Keywords:
  Anti-obesity Agents Body Weight Changes Drug Side Effects
• Source:
  Clin Obes. 13(5):e12609
• Pubmed ID:
  37455380
• Pubmed Central ID:
  PMC10528729
• Document Type:
  Journal Article
• Funding:
  T32HL007180/HL/NHLBI NIH HHSUnited States/ ; U2C OD023196/OD/NIH HHSUnited States/ ; OT2 OD026551/OD/NIH HHSUnited States/ ; OT2 OD026552/OD/NIH HHSUnited States/ ; OT2 OD025337/OD/NIH HHSUnited States/ ; OT2 OD026555/OD/NIH HHSUnited States/ ; OT2 OD026550/OD/NIH HHSUnited States/ ; OT2 OD023205/OD/NIH HHSUnited States/ ; OT2 OD025276/OD/NIH HHSUnited States/ ; OT2 OD026557/OD/NIH HHSUnited States/ ; OT2 OD026554/OD/NIH HHSUnited States/ ; U24 OD023163/OD/NIH HHSUnited States/ ; OT2 OD023206/OD/NIH HHSUnited States/ ; P50 MH115842/MH/NIMH NIH HHSUnited States/ ; OT2 OD026556/OD/NIH HHSUnited States/ ; UH3HL155801/HL/NHLBI NIH HHSUnited States/ ; U24 OD023176/OD/NIH HHSUnited States/ ; OT2 OD026548/OD/NIH HHSUnited States/ ; UH3 HL155801/HL/NHLBI NIH HHSUnited States/ ; OT2 OD025315/OD/NIH HHSUnited States/ ; U24 OD023121/OD/NIH HHSUnited States/ ; P30 AG072980/AG/NIA NIH HHSUnited States/ ; OT2 OD026549/OD/NIH HHSUnited States/ ; T32 HL007180/HL/NHLBI NIH HHSUnited States/ ; OT2 OD025277/OD/NIH HHSUnited States/ ; P50MH115842/MH/NIMH NIH HHSUnited States/ ; U24 OD023176/CD/ODCDC CDC HHSUnited States/ ; OT2 OD026553/OD/NIH HHSUnited States/
• Volume:
  13
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:6621dff2ed7d25a923927fa1763ae5e62428144784c8841b392d663935575da8096b621437c2ba06c1e8458e564ee27f0e1c589806b0a39e3a8183aa5159cc41
• Download URL:
  https://stacks.cdc.gov/view/cdc/133516/cdc_133516_DS1.pdf
• File Type:
  [PDF - 258.95 KB ]