Early-Onset Type 2 Diabetes as a Risk Factor for End-Stage Renal Disease in Patients With Diabetic Kidney Disease

Details

• Journal Article:
  Preventing Chronic Disease (PCD)
• Personal Author:
  Zheng, Li ; Chen, Xiangjun ; Luo, Ting ; Ran, Xi ; Hu, Jinbo ; Cheng, Qingfeng ; Yang, Shumin ; Wu, Jinshan ; Li, Qifu ; Wang, Zhihong
• Description:
  Introduction
  
  Compared with the typical onset of type 2 diabetes in middle age or older, type 2 diabetes with early age of onset has a higher risk of diabetes-related complications. It is unclear whether the early age of diabetes diagnosis would affect the development of end-stage renal disease (ESRD) in patients with diabetic kidney disease (DKD) who are at higher risk of ESRD.
  
  Methods
  
  We enrolled 1,111 type 2 diabetes patients with DKD in this study. We used the age at diabetes diagnosis of younger than 40 years to define early-onset diabetes and 40 years or older to define late-onset diabetes. Medical history, anthropometry, and laboratory indicators were documented. ESRD was defined by estimated glomerular filtration rate (eGFR) of less than 15 mL/min/1.73 m2 or dialysis. Logistic regression analysis was used to explore the association between early-onset diabetes and ESRD.
  
  Results
  
  Early-onset diabetes patients had a longer diabetes duration, higher body mass index, and worse blood lipid metabolism profile. Compared with late-onset diabetes patients, patients with early-onset diabetes had a prevalence of ESRD that was twofold higher (9.2% vs 4.3%; P = .009). Univariate analysis showed that early-onset diabetes was a risk factor for ESRD in patients with DKD (P < .05). In multivariate logistic regression analysis, even after adjusting for sex, traditional metabolic factors, drug factors, and diabetes duration, the risk of ESRD in patients with early-onset diabetes was still 3.58-fold higher than in subjects with late-onset (95% CI, 1.47–8.74; P = .005).
  
  Conclusions
  
  In patients with DKD, early-onset type 2 diabetes is an independent risk factor of ESRD.
  
  
• Subjects:
  Original Research
• Source:
  Prev Chronic Dis. 2020; 17
• ISSN:
  1545-1151
• Pubmed ID:
  32614772
• Pubmed Central ID:
  PMC7367068
• Document Type:
  Journal Article
• Volume:
  17
• Collection(s):
  Preventing Chronic Disease
• Main Document Checksum:
  urn:sha-512:303fccb487a016d0b7cac63c322859eb167c2576bf421312ad0c144f3a06871aa70f28c586c31ac7374bc43167083f2d09313ff704c6b1e880c97b39a07905ef
• Download URL:
  https://stacks.cdc.gov/view/cdc/91151/cdc_91151_DS1.pdf
• File Type:
  [PDF - 506.28 KB ]