Infectious etiologies of intussusception among children <2 years old in 4 Asian countries

Details

• Alternative Title:
  J Infect Dis
• Personal Author:
  Burnett, Eleanor ; Kabir, Furqan ; Van Trang, Nguyen ; Rayamajhi, Ajit ; Satter, Syed M ; Liu, Jie ; Yousafzai, Mohammad Tahir ; Anh, Dang Duc ; Basnet, Anupama Thapa ; Flora, Meerjady S. ; Houpt, Eric ; Qazi, Saqib Hamid ; Canh, Tran Minh ; Rayamajhi, Anjana Karki ; Saha, Bablu K ; Saddal, Nasir Saleem ; Muneer, Sehrish ; Hung, Pham Hoang ; Islam, Towhidul ; Ali, Syed Asad ; Tate, Jacqueline E. ; Yen, Catherine ; Parashar, Umesh D.
• Description:
  Background
  
  The etiology of intussusception, the leading cause of bowel obstruction in infants, is unknown in most cases. Adenovirus has been associated with intussusception, and a slightly increased risk of intussusception with rotavirus vaccination has been found in several countries. We conducted a case-control study among children <2 years old in Bangladesh, Nepal, Pakistan, and Vietnam to evaluate infectious etiologies of intussusception before rotavirus vaccine introduction.
  
  Methods
  
  From 2015-2017, we enrolled one-to-one matched intussusception cases and hospital controls; 249 pairs are included. Stool specimens were tested for 37 infectious agents using TaqMan Array technology. We used conditional logistic regression to estimate the odds ratio and 95% confidence interval (CI) of each pathogen associated with intussusception in a pooled analysis and in quantitative sub-analyses.
  
  Results
  
  Adenovirus (OR: 2.67, 95%CI: 1.75, 4.36) and human herpes virus 6 (OR: 3.50, 95%CI: 1.15, 10.63) were detected more frequently in cases than controls. Adenovirus C detection <20 quantification cycles was associated with intussusception (OR: 18.59, 95%CI: 2.45, 140.89). Wild-type rotavirus was not associated with intussusception (OR: 1.07, 95%CI: 0.52, 2.22).
  
  Conclusions
  
  In this comprehensive evaluation, adenovirus and HHV-6 were associated with intussusception. Future research is needed to better understand mechanisms leading to intussusception, particularly after rotavirus vaccination.
  
  
• Subjects:
  Adenoviruses, Human Asia Case-Control Studies Child, Preschool Feces Female Herpesvirus 6, Human Humans Infant Infant, Newborn Intussusception Logistic Models Male Rotavirus Rotavirus Vaccines

  More +
• Keywords:
  Adenovirus Intestinal Obstruction Intussusception Rotavirus Viral Pathogens
• Source:
  J Infect Dis. 221(9):1499-1505
• Pubmed ID:
  31754717
• Pubmed Central ID:
  PMC7371463
• Document Type:
  Journal Article
• Funding:
  CC999999/ImCDC/Intramural CDC HHSUnited States/
• Volume:
  221
• Issue:
  9
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:a00ff85d8c8d24f54090cf9e32b92e1e2ddfdc9413c9d78001a1ad020551808b
• Download URL:
  https://stacks.cdc.gov/view/cdc/90856/cdc_90856_DS1.pdf
• File Type:
  [PDF - 106.34 KB ]