Current and new rotavirus vaccines

Details

• Alternative Title:
  Curr Opin Infect Dis
• Personal Author:
  Burke, Rachel M. ; Tate, Jacqueline E. ; Kirkwood, Carl D. ; Steele, A. Duncan ; Parashar, Umesh D.
• Description:
  Recent findings
  
  Data generated from use of currently available products supports their effectiveness and impact in diverse settings. Rotavirus vaccines have a favorable risk–benefit profile, but previous associations of rotavirus vaccination with intussusception necessitate continued monitoring for this rare but serious adverse event. Implementation of rotavirus vaccines was jeopardized in late 2018 and 2019 by a shortage of vaccine supply. Fortunately, with the prequalification of two additional vaccines in 2018, countries have increased choice in products with different characteristics, pricing, and implementation strategies. Other vaccines currently in development may open up further immunization strategies, such as neonatal vaccination schedules or parenteral administration.
  
  Summary
  
  Rotavirus vaccines have demonstrated impact in reducing diarrheal morbidity and mortality worldwide. As countries begin to introduce the newly prequalified vaccines, additional data will become available on the safety and effectiveness of those products. Products in the pipeline have distinct profiles and could be an essential part of the expansion of rotavirus vaccine use worldwide.
  
  
• Subjects:
  Diarrhea Drug-Related Side Effects And Adverse Reactions Drug Development GASTROINTESTINAL INFECTIONS: Edited By Gagandeep Kang And Eric R. Houpt Humans Immunization Intussusception Pediatric Gastroenteritis Rotavirus Rotavirus Infections Rotavirus Vaccines Survival Analysis Treatment Outcome

  More +
• Source:
  Curr Opin Infect Dis. 2019; 32(5):435-444
• Pubmed ID:
  31305493
• Pubmed Central ID:
  PMC6749957
• Document Type:
  Journal Article
• Volume:
  32
• Issue:
  5
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:8ac9186d362dd64f79bfb5c8d301fca84b1d9b2f0822d472fd37a990455c6b0f
• Download URL:
  https://stacks.cdc.gov/view/cdc/90843/cdc_90843_DS1.pdf
• File Type:
  [PDF - 647.63 KB ]