substances and childhood neurodevelopment

Details

• Alternative Title:
  Environ Pollut
• Personal Author:
  Spratlen, Miranda J ; Perera, Frederica P ; Lederman, Sally Ann ; Rauh, Virginia A ; Robinson, Morgan ; Kannan, Kurunthachalam ; Trasande, Leonardo ; Herbstman, Julie
• Description:
  Perfluoroalkyl substances (PFAS) were among various persistent organic pollutants suspected to have been released during the collapse of the World Trade Center (WTC) on 9/11. Evidence on the association between prenatal PFAS exposure and child neurodevelopment is limited and inconsistent. This study evaluated the association between prenatal PFAS exposure and child cognitive outcomes measured at 5 different time points in a population prenatally exposed to the WTC disaster. The study population included 302 pregnant women in the Columbia University WTC birth cohort enrolled between December 13, 2001 and June 26, 2002 at three hospitals located near the WTC site: Beth Israel, St. Vincent's, and New York University Downtown. We evaluated the association between prenatal exposure to four PFAS (perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorohexanesulfonic acid (PFHxS), perfluorononanoic acid (PFNA)) and child neurodevelopment measured using the Bayley Scales of Infant Development (BSID-II) at approximately 1, 2 and 3 years of age and using The Wechsler Preschool and Primary Scale of Intelligence (WPPSI) at approximately 4 and 6 years of age. Geometric mean (range) concentrations of PFAS were 6.03 (1.05, 33.7), 2.31 (0.18, 8.14), 0.43 (
• Subjects:
  Alkanesulfonic Acids Child Child, Preschool Environmental Pollutants Female Fluorocarbons Humans Male Pregnancy Prenatal Exposure Delayed Effects
• Source:
  Environ Pollut. 263(Pt B):114444
• Pubmed ID:
  32272335
• Pubmed Central ID:
  PMC7362877
• Document Type:
  Journal Article
• Funding:
  P50 ES015905/ES/NIEHS NIH HHSUnited States/ ; U01OH011299/ACL/ACL HHSUnited States/ ; U01 OH010714/OH/NIOSH CDC HHSUnited States/ ; U01 OH010394/OH/NIOSH CDC HHSUnited States/ ; P50 ES009600/ES/NIEHS NIH HHSUnited States/ ; U01 OH011299/OH/NIOSH CDC HHSUnited States/ ; P30 ES009089/ES/NIEHS NIH HHSUnited States/
• Place as Subject:
  Israel ; New York
• Volume:
  263
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:7a27e4c086c3b3b1771f6ceca634d3c4c9c4d362da1474fbbec86e6d5291b93f
• Download URL:
  https://stacks.cdc.gov/view/cdc/90694/cdc_90694_DS1.pdf
• File Type:
  [PDF - 837.98 KB ]