Details:

Alternative Title:
Epidemiol Infect
Personal Author:
GLEASON, B. L. ; FOSTER, S. ; WILT, G. E. ; MILES, B. ; LEWIS, B. ; ... More +
GLEASON, B. L. ; FOSTER, S. ; WILT, G. E. ; MILES, B. ; LEWIS, B. ; CAUTHEN, K. ; KING, M. ; BAYOR, F. ; CONTEH, S. ; SESAY, T. ; KAMARA, S. I. ; LAMBERT, G. ; FINLEY, P. ; BEYELER, W. ; MOORE, T. ; GAUDIOSO, J. ; KILMARX, P. H. ; REDD, J. T. Less -
Description:
We performed a spatial-temporal analysis to assess household risk factors for Ebola virus disease (Ebola) in a remote, severely-affected village. We defined a household as a family's shared living space and a case-household as a household with at least one resident who became a suspect, probable, or confirmed Ebola case from 1 August 2014 to 10 October 2014. We used Geographic Information System (GIS) software to calculate inter-household distances, performed space-time cluster analyses, and developed Generalized Estimating Equations (GEE). Village X consisted of 64 households; 42% of households became case-households over the observation period. Two significant space-time clusters occurred among households in the village; temporal effects outweighed spatial effects. GEE demonstrated that the odds of becoming a case-household increased by 4·0% for each additional person per household (P < 0·02) and 2·6% per day (P < 0·07). An increasing number of persons per household, and to a lesser extent, the passage of time after onset of the outbreak were risk factors for household Ebola acquisition, emphasizing the importance of prompt public health interventions that prioritize the most populated households. Using GIS with GEE can reveal complex spatial-temporal risk factors, which can inform prioritization of response activities in future outbreaks.
Subject:
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Disease Outbreaks
Ebolavirus
Family Characteristics
Geographic Mapping
Hemorrhagic Fever, Ebola
Humans
Quarantine
Risk Factors
Spatial Analysis

Source:
Epidemiol Infect. 145(14):2921-2929
Pubmed ID:
28826426
Pubmed Central ID:
PMC7315611
Document Type:
Journal Article
Funding:
CC999999/ImCDC/Intramural CDC HHS/United States
Place as Subject:
Sierra Leone
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:bbe93451ce47d8b4b6fc1b256acd8a386e0b86638b672b8d46edbb7d2aeb8c6c
File Type:

Supporting Files

• 	NIHMS1598537-supplement-supplementary_material.docx	docx
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