Associations between PM2.5 and risk of preterm birth among liveborn infants

Details

• Alternative Title:
  Ann Epidemiol
• Personal Author:
  Alman, Breanna L. ; Stingone, Jeanette A. ; Yazdy, Mahsa ; Botto, Lorenzo D. ; Desrosiers, Tania A. ; Pruitt, Shannon ; Herring, Amy H. ; Langlois, Peter H. ; Nembhard, Wendy N. ; Shaw, Gary M. ; Olshan, Andrew F. ; Luben, Thomas J.
• Description:
  Purpose
  
  Studies suggest exposure to ambient particulate matter less than 2.5 μg/m3 in aerodynamic diameter (PM2.5) may be associated with preterm birth (PTB), but few have evaluated how this is modified by ambient temperature. We investigated the relationship between PM2.5 exposure during pregnancy and PTB in infants without birth defects (1999–2006) and enrolled in the National Birth Defects Prevention Study and how it is modified by concurrent temperature.
  
  Methods
  
  PTB was defined as spontaneous or iatrogenic delivery before 37 weeks. Exposure was assigned using inverse distance weighting with up to four monitors within 50 kilometers of maternal residence. To account for state-level variations, a Bayesian two-level hierarchal model was developed.
  
  Results
  
  PTB was associated with PM2.5 during the third and fourth months of pregnancy (range: (odds ratio (95% confidence interval) = 1.00 (0.35, 2.15) to 1.49 (0.82, 2.68) and 1.31 (0.56, 2.91) to 1.62 (0.7, 3.32), respectively); no week of exposure conveyed greater risk. Temperature may modify this relationship; higher local average temperatures during pregnancy yielded stronger positive relationships between PM2.5 and PTB compared to nonstratified results.
  
  Conclusions
  
  Results add to literature on associations between PM2.5 and PTB, underscoring the importance of considering co-exposures when estimating effects of PM2.5 exposure during pregnancy.
  
  
• Subjects:
  Adolescent Adult Air Pollutants Air Pollution Bayes Theorem Environmental Exposure Female Humans Infant, Newborn Live Birth Maternal Exposure Particle Size Particulate Matter Pregnancy Pregnancy Outcome Premature Birth Risk Factors Temperature United States Young Adult

  More +
• Keywords:
  Air Pollution Buprenorphine Methadone Mortality Naltrexone PM2.5 Preterm Birth Treatment
• Source:
  Ann Epidemiol. 39:46-53.e2
• Pubmed ID:
  31678056
• Pubmed Central ID:
  PMC7315599
• Document Type:
  Journal Article
• Funding:
  U01 DD000491/DD/NCBDD CDC HHSUnited States/ ; CDP 13-003/HX/HSRD VAUnited States/ ; U01 DD001231/DD/NCBDD CDC HHSUnited States/ ; U01 DD001224/DD/NCBDD CDC HHSUnited States/ ; EP-D-18-001/EPA/EPAUnited States/ ; EPA999999/ImEPA/Intramural EPAUnited States/ ; U01 DD001226/DD/NCBDD CDC HHSUnited States/
• Volume:
  39
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha-512:4a97a9ff00335d8981aded079d3e43856712fcfa6ba14c3cf10ca744f8409833b0dbb6c56827774623f0f0cff63589bae2bfce087cd3950d246bcf1e0f4ae382
• Download URL:
  https://stacks.cdc.gov/view/cdc/89863/cdc_89863_DS1.pdf
• File Type:
  [PDF - 854.91 KB ]