Details:

Alternative Title:
Cancer Epidemiol Biomarkers Prev
Personal Author:
Sangaramoorthy, Meera ; Yang, Juan ; DeRouen, Mindy C. ; Ho, Chanda ; Somsouk, Ma ; ... More +
Sangaramoorthy, Meera ; Yang, Juan ; DeRouen, Mindy C. ; Ho, Chanda ; Somsouk, Ma ; Tana, Michele M. ; Thompson, Caroline A. ; Gibbons, Joseph ; Gomez, Scarlett Lin ; Shariff-Marco, Salma Less -
Description:
Background:

Given changes in hepatocellular carcinoma (HCC) incidence and the ethno-demographic landscape, we analyzed recent HCC incidence patterns and trends in California.

Methods:

Using 47,992 primary, invasive HCC cases diagnosed 1988–2014 from the California Cancer Registry, we calculated age-adjusted incidence rates (IRs), annual percent change (APC), and 95% confidence intervals (CIs), by sex, race/ethnicity, and nativity among Hispanics and Asian ethnic groups.

Results:

Compared to non-Hispanic Whites (NHWs), all other racial/ethnic groups had higher HCC incidence. Vietnamese had the highest IRs (males: 47.4, 95% CI = 45.3 to 49.5, females: 14.1, 95% CI = 13.0 to 15.3). Foreign-born Chinese, Japanese, Korean, and Vietnamese had higher incidence than U.S.-born. The reverse was observed for Hispanic males while no differences by nativity was seen for Hispanic females. IRs increased most for NHWs. Among Asians, male and female Filipinos and Japanese males experienced rate increases, while male and female Koreans and Chinese males experienced rate decreases. U.S.-born male and female Hispanics and Japanese had higher APCs than foreign-born, as did Filipino males, while Chinese males had a reverse pattern. Annual increases in HCC incidence slowed down in recent years for U.S.-born Hispanic males and females and stabilized among male NHWs and non-Hispanic Blacks. For some Asian groups, early time periods exhibited increasing/stable APCs while later time periods showed decreasing APCs.

Conclusions:

We found significant racial/ethnic and nativity differences in HCC IRs and trends.

Impact:

With changing trends, closer surveillance of HCC incidence by disaggregated race/ethnicity and nativity is warranted among Hispanics and Asians.


Subject:
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Adult Aged Aged, 80 And Over Article Asian Americans California Carcinoma, Hepatocellular Cohort Studies Female Health Status Disparities Hispanic Americans Humans Incidence Liver Neoplasms Male Middle Aged SEER Program Sex Factors
Source:
Cancer Epidemiol Biomarkers Prev. 29(1):79-87
Pubmed ID:
31719066
Pubmed Central ID:
PMC6986425
Document Type:
Journal Article
Funding:
HHSN261201800032C/CA/NCI NIH HHS/United States ; HHSN261201800009C/CA/NCI NIH HHS/United States ; NU58DP006344/DP/NCCDPHP CDC HHS/United States ; HHSN261201800015I/CA/NCI NIH HHS/United States ; P30 CA023100/CA/NCI NIH HHS/United States ; ... More +
HHSN261201800032C/CA/NCI NIH HHS/United States ; HHSN261201800009C/CA/NCI NIH HHS/United States ; NU58DP006344/DP/NCCDPHP CDC HHS/United States ; HHSN261201800015I/CA/NCI NIH HHS/United States ; P30 CA023100/CA/NCI NIH HHS/United States ; HHSN261201800032I/CA/NCI NIH HHS/United States ; HHSN261201800015C/CA/NCI NIH HHS/United States ; HHSN261201800009I/CA/NCI NIH HHS/United States Less -
Collection(s):
CDC Public Access
Main Document Checksum:
[+]
urn:sha256:a680673426e775c35f360bdbdd08060820aef1927218732bccee59b68b421852
Download URL:
https://stacks.cdc.gov/view/cdc/89669/cdc_89669_DS1.pdf
File Type:

Supporting Files

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  	nihms-1542653-f0001.jpg	jpeg
  	nihms-1542653.nxml	xml
  	NIHMS1542653-supplement-1.pdf	pdf
  	NIHMS1542653-supplement-2.pdf	pdf

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