Cancer Risk among Lung Transplant Recipients with Cystic Fibrosis

Details

• Alternative Title:
  J Cyst Fibros
• Personal Author:
  Fink, Aliza K. ; Yanik, Elizabeth L. ; Marshall, Bruce C. ; Wilschanski, Michael ; Lynch, Charles F. ; Austin, April A. ; Copeland, Glenn ; Safaeian, Mahboobeh ; Engels, Eric A.
• Description:
  Background:
  
  Previous studies demonstrated increased digestive tract cancers among individuals with cystic fibrosis (CF), particularly among lung transplant recipients. We describe cancer incidence among CF and non-CF lung recipients.
  
  Methods:
  
  We used data from the US transplant registry and 16 cancer registries. Standardized incidence ratios (SIRs) compared cancer incidence to the general population, and competing risk methods were used for the cumulative incidence of colorectal cancer.
  
  Results:
  
  We evaluated 10,179 lung recipients (1,681 with CF). Risk was more strongly increased in CF recipients than non-CF recipients for overall cancer (SIR 9.9 vs. 2.7) and multiple cancers including colorectal cancer (24.2 vs. 1.7), esophageal cancer (56.3 vs. 1.3), and non-Hodgkin lymphoma (61.8 vs. 9.4). At five years post-transplant, colorectal cancer was diagnosed in 0.3% of CF recipients aged <50 at transplant and 6.4% aged ≥50.
  
  Conclusions:
  
  CF recipients have increased risk for colorectal cancer, suggesting a need for enhanced screening.
  
  
• Subjects:
  Adult Article Cancer Colorectal Neoplasms Cystic Fibrosis Female Humans Incidence Long Term Adverse Effects Lung Transplantation Male Middle Aged Registries Risk Assessment Transplant Transplant Recipients United States

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• Source:
  J Cyst Fibros. 16(1):91-97
• Pubmed ID:
  27539828
• Pubmed Central ID:
  PMC7296446
• Document Type:
  Journal Article
• Funding:
  N01PC35137/CA/NCI NIH HHS/United States ; P30 CA030199/CA/NCI NIH HHS/United States ; Z01 CP010150-08/ImNIH/Intramural NIH HHS/United States ; N01PC35139/CA/NCI NIH HHS/United States ; U58 DP000848/DP/NCCDPHP CDC HHS/United States ; HHSN261201000035C/CA/NCI NIH HHS/United States ; U58 DP003879/DP/NCCDPHP CDC HHS/United States ; N01PC35143/CA/NCI NIH HHS/United States ; HHSN261201200021I/CP/NCI NIH HHS/United States ; N01PC35142/CA/NCI NIH HHS/United States ; HHSN261201000034C/CA/NCI NIH HHS/United States ; U58 DP000832/DP/NCCDPHP CDC HHS/United States ; HHSN261201000024C/CA/NCI NIH HHS/United States ; P30 CA086862/CA/NCI NIH HHS/United States ; HHSN261201000036C/CA/NCI NIH HHS/United States ; HHSN261201000037C/CA/NCI NIH HHS/United States ; HHSN261201200017I/CA/NCI NIH HHS/United States
• Volume:
  16
• Issue:
  1
• Collection(s):
  CDC Public Access
• Main Document Checksum:
  urn:sha256:164928c6630d74454377deb5018c2558ff85e412532bda658d74517500d6fe83
• Download URL:
  https://stacks.cdc.gov/view/cdc/89386/cdc_89386_DS1.pdf
• File Type:
  [PDF - 1.06 MB ]