Details:

Alternative Title:
Clin Infect Dis
Personal Author:
Park, Se Eun ; Toy, Trevor ; Cruz Espinoza, Ligia Maria ; Panzner, Ursula ; Mogeni, Ondari D ; ... More +
Park, Se Eun ; Toy, Trevor ; Cruz Espinoza, Ligia Maria ; Panzner, Ursula ; Mogeni, Ondari D ; Im, Justin ; Poudyal, Nimesh ; Pak, Gi Deok ; Seo, Hyeongwon ; Chon, Yun ; Schütt-Gerowitt, Heidi ; Mogasale, Vittal ; Ramani, Enusa ; Dey, Ayan ; Park, Ju Yeong ; Kim, Jong-Hoon ; Seo, Hye Jin ; Jeon, Hyon Jin ; Haselbeck, Andrea ; Conway Roy, Keriann ; MacWright, William ; Adu-Sarkodie, Yaw ; Owusu-Dabo, Ellis ; Osei, Isaac ; Owusu, Michael ; Rakotozandrindrainy, Raphaël ; Soura, Abdramane Bassiahi ; Kabore, Leon Parfait ; Teferi, Mekonnen ; Okeke, Iruka N ; Kehinde, Aderemi ; Popoola, Oluwafemi ; Jacobs, Jan ; Lunguya Metila, Octavie ; Meyer, Christian G ; Crump, John A ; Elias, Sean ; Maclennan, Calman A ; Parry, Christopher M ; Baker, Stephen ; Mintz, Eric D ; Breiman, Robert F ; Clemens, John D ; Marks, Florian ; Less -
Description:
Background Invasive salmonellosis is a common community-acquired bacteremia in persons residing in sub-Saharan Africa. However, there is a paucity of data on severe typhoid fever and its associated acute and chronic host immune response and carriage. The Severe Typhoid Fever in Africa (SETA) program, a multicountry surveillance study, aimed to address these research gaps and contribute to the control and prevention of invasive salmonellosis. Methods A prospective healthcare facility–based surveillance with active screening of enteric fever and clinically suspected severe typhoid fever with complications was performed using a standardized protocol across the study sites in Burkina Faso, the Democratic Republic of Congo (DRC), Ethiopia, Ghana, Madagascar, and Nigeria. Defined inclusion criteria were used for screening of eligible patients for enrollment into the study. Enrolled patients with confirmed invasive salmonellosis by blood culture or patients with clinically suspected severe typhoid fever with perforation were eligible for clinical follow-up. Asymptomatic neighborhood controls and immediate household contacts of each case were enrolled as a comparison group to assess the level of Salmonella-specific antibodies and shedding patterns. Healthcare utilization surveys were performed to permit adjustment of incidence estimations. Postmortem questionnaires were conducted in medically underserved areas to assess death attributed to invasive Salmonella infections in selected sites. Results Research data generated through SETA aimed to address scientific knowledge gaps concerning the severe typhoid fever and mortality, long-term host immune responses, and bacterial shedding and carriage associated with natural infection by invasive salmonellae. Conclusions SETA supports public health policy on typhoid immunization strategy in Africa.
Subject:
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Host Immunity And Carriage
Invasive Salmonellosis
Severe Typhoid Fever
Sub-Saharan Africa
Supplement Articles
Surveillance Protocol

Source:
Clin Infect Dis. 2019; 69(Suppl 6):S422-S434
Pubmed ID:
31665779
Pubmed Central ID:
PMC6821161
Document Type:
Journal Article ;
Collection(s):
CDC Public Access
Main Document Checksum:
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urn:sha256:d199b6f2f09d1c1b1c6c8a1fb6389532318757218edabfb20fc697aaabe4b0e2
File Type:

Supporting Files

• 	ciz715.nxml	xml
  	ciz715f0001.gif	gif
  	ciz715f0001.jpg	jpeg
  	ciz715_suppl_supplementary_table_1.docx	docx

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