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Occupational livestock or animal dust exposure and offspring cancer risk in Denmark, 1968–2016
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7 2020
Source: Int Arch Occup Environ Health. 93(5):659-668 -
Alternative Title:Int Arch Occup Environ Health
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Personal Author:
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Description:Objective:
To examine associations with occupational livestock or other animal dust exposure and offspring cancer risk.
Methods:
In this population-based case-control study of Danish children aged <17 years old, 5,078 childhood cancer cases diagnosed 1968–2016 were matched to cancer-free controls by birth year and sex (n=123,228). Occupational livestock or animal dust exposure was identified using a job-exposure matrix. We employed multivariable conditional logistic regression models to estimate associations with offspring cancer for births 1968–2016 and 1989–2016, with the latter timeframe reflecting a period of presumed higher exposure due to changes in Danish farming practices. Sensitivity analyses considered place of birth (urban areas vs. rural areas and small towns).
Results:
For births 1968–2016, paternal exposure from offspring birth to cancer diagnosis was associated with central nervous system tumors (adjusted odds ratio [OR]=1.30, 95% confidence interval [CI]=1.04–1.63) and germ cell tumors (OR=1.82, 95% CI=1.05–3.27), while maternal pregnancy exposure was associated with astrocytoma (OR=1.89, 95% CI=1.00–3.57). For births 1989–2016, paternal exposure from offspring birth to cancer diagnosis was negatively associated with acute lymphoid leukemia (OR=0.58, 95% CI=0.33–1.00). For births in rural areas only, maternal exposure from offspring birth to cancer diagnosis was positively associated with acute myeloid leukemia (OR=2.16, 95% CI=1.09–4.29).
Conclusions:
This study suggests that paternal occupational animal exposure is associated with offspring germ cell tumors, and maternal pregnancy exposure with astrocytomas. Our results are mixed with respect to leukemia subtypes.
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Pubmed ID:32025796
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Pubmed Central ID:PMC7261625
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