Effectiveness and Tolerability of Oral Amoxicillin in Pregnant Women with Active Syphilis, Japan, 2010–2018

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Nishijima, Takeshi ; Kawana, Kei ; Fukasawa, Ichio ; Ishikawa, Naoko ; Taylor, Melanie M. ; Mikamo, Hiroshige ; Kato, Kiyoko ; Kitawaki, Jo ; Fujii, Tomoyuki
• Corporate Authors:
  Women’s Health Care Committee ; Japan Society of Obstetrics and Gynecology
• Description:
  We conducted a nationwide retrospective study in Japan to evaluate the effectiveness of oral amoxicillin or ampicillin as alternatives to injectable benzathine penicillin G for treating pregnant women with syphilis and preventing congenital syphilis (CS). We investigated 80 pregnant women with active syphilis treated with amoxicillin or ampicillin during 2010-2018. Overall, 21% (15/71) had pregnancies resulting in CS cases, and 3.8% (3/80) changed therapies because of side effects. Among 26 patients with early syphilis, no CS cases occurred, but among 45 with late syphilis, 15 (33%) CS cases occurred. Among 57 patients who started treatment >60 days before delivery, 8 (14%) had CS pregnancy outcomes. We found oral amoxicillin potentially ineffective for preventing CS cases among pregnant women with late syphilis but potentially effective in those with early syphilis. Prospective studies are needed to definitively evaluate the efficacy of amoxicillin for the treatment of pregnant women with syphilis to prevent CS.
• Subjects:
  Active Syphilis Adverse Birth Outcomes Alternative Regimen Amoxicillin Ampicillin Bacteria Congenital Syphilis Effectiveness Effectiveness And Tolerability Of Oral Amoxicillin In Pregnant Women With Active Syphilis, Japan, 2010–2018 Japan Mother-To-Child Transmission Nationwide Multicenter Study Oral Penicillin Original Research Pregnancy Prevention Research Safety Sexually Transmitted Infection Tolerability Treponema Pallidum

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• Source:
  Emerg Infect Dis. 26(6):1192-1200
• Pubmed ID:
  32441638
• Pubmed Central ID:
  PMC7258477
• Document Type:
  Journal Article
• Volume:
  26
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:6872c33f9d2d2373ea1f6fb4663eaaa504781674e2f14da2cf6347827110a282
• Download URL:
  https://stacks.cdc.gov/view/cdc/88880/cdc_88880_DS1.pdf
• File Type:
  [PDF - 844.27 KB ]