Statin Use and Influenza Vaccine Effectiveness in Persons >65 Years of Age, Taiwan

Details

• Alternative Title:
  Emerg Infect Dis
• Personal Author:
  Tsai, Lung-Wen ; Chen, Yung-Tai ; Shih, Chia-Jen ; Ou, Shuo-Ming ; Chao, Pei-Wen ; Lo, Shih-Hsiu
• Description:
  Debates on whether statin use reduces the effectiveness of influenza vaccines against critical illness and death among persons >65 years of age continue. We conducted a study of 9,427,392 persons >65 years of age who did and did not receive influenza vaccinations during 12 consecutive influenza seasons, 2000-01 through 2011-12. Using data from Taiwan's National Health Insurance Research Database, we performed propensity score-matching to compare vaccinated persons with unvaccinated controls. After propensity score-matching, the vaccinated group had lower risks for in-hospital death from influenza and pneumonia and for hospitalization for pneumonia and influenza, circulatory conditions, and critical illnesses compared with the unvaccinated group. We stratified the 2 groups by statin use and analyzed data by interaction analysis and saw no statistically significant difference. We found that influenza vaccine effectively reduced risks for hospitalization and death in persons >65 years of age, regardless of statin use.
• Subjects:
  Critical Illness Hospitalization Influenza Research Respiratory Diseases Statin Use And Influenza Vaccine Effectiveness In Persons ≥ 65 Years Of Age, Taiwan Taiwan Vaccine-Preventable Diseases Vaccines Viruses
• Source:
  Emerg Infect Dis. 26(6):1243-1250
• Pubmed ID:
  32441242
• Pubmed Central ID:
  PMC7258485
• Document Type:
  Journal Article
• Volume:
  26
• Issue:
  6
• Collection(s):
  Emerging Infectious Diseases
• Main Document Checksum:
  urn:sha256:79ed83124007239a58a2851b96ce69c4f9dc16472eed58c3feb3835d177ed57b
• Download URL:
  https://stacks.cdc.gov/view/cdc/88868/cdc_88868_DS1.pdf
• File Type:
  [PDF - 1.08 MB ]